DESCRIPTION:

QTL associated with bronchial hyperresponsiveness 2. The confidence interval is Chr15:64266047-26567217 bp,+strand

LABEL:

QTL-Bhr2-Mouse-Chr 15

SCORE TYPE:

Binary

DATE ADDED:

2012-04-02

DATE UPDATED:

2024-04-25

SPECIES:

URI:

http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:104734

AUTHORS:

De Sanctis GT, Merchant M, Beier DR, Dredge RD, Grobholz JK, Martin TR, Lander ES, Drazen JM

TITLE:

Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice.

JOURNAL:

Nature genetics Oct 1995, Vol 11, pp. 150-4

ABSTRACT:

Airway hyperresponsiveness is a key characteristic of human asthma and a marker for asthma-like conditions in animals. F1 mice derived from A/J and C57BL/6J display a phenotype which resembles the asthma-like phenotype of the A/J mice. Since airway responsiveness failed to segregate as a mendelian trait, we show significant linkage at two loci, Bhr1 (lod = 3.0) and Bhr2 (lod = 3.7) on chromosomes 2 and 15. A third locus, Bhr3 (lod = 2.83), maps to chromosome 17. Each of these loci maps near candidate loci implicated in the pathobiology of asthma. Our study represents the first linkages established through a genome-wide survey of airway hyperresponsiveness in any mammal. PUBMED: 7550342
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