DESCRIPTION:
Lewis rats operantly self-administer drugs of abuse including nicotine, whereas Fisher self-administer poorly. Lewis vs Fischer Ratio shown. Laser capture microdissection was used to obtain nucleus accumbens shell GABA neurons project to ventral pallidum labeled by Fluorogold. The gene expression profiles of these neurons were obtained using Affymetrix Rat Gene ST 1.0 microarrays. A total of 322 genes were differentially expressed at a Lewis vs Fisher ratio of >1.5-fold (P < 0.05 and FDR < 5%).
LABEL:
Lewis vs Fisher Rats Na neurons
SCORE TYPE:
Effect
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