DESCRIPTION:

Consumption level alcohol preference, Two bottle preference test; voluntary alcohol consumption. Additive, LOD 8.6 p-value 0.0001 Peak Marker: D4Rat34 spans D4Mgh15( 54879077)- D4Rat55(127941994) Strains were P, NP.

LABEL:

QTL-Alc21-Rat-Chr 4

SCORE TYPE:

Binary

DATE ADDED:

None

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Carr LG, Foroud T, Bice P, Gobbett T, Ivashina J, Edenberg H, Lumeng L, Li TK

TITLE:

A quantitative trait locus for alcohol consumption in selectively bred rat lines.

JOURNAL:

Alcoholism, clinical and experimental research Jun 1998, Vol 22, pp. 884-7

ABSTRACT:

Selective breeding for high and low alcohol consumption led to the establishment of alcohol-preferring (P) and alcohol-nonpreferring (NP) rat lines that differ greatly in their alcohol consumption. These lines were inbred and F2 intercross progenies were generated to detect quantitative trait loci (QTLs) influencing alcohol consumption. A QTL on chromosome 4 was identified with a maximum lod score of 8.6. This QTL acts in an additive fashion and accounts for 11% of the total phenotypic variability and approximately one-third of the genetic variability. Neuropeptide Y, an endogenous anxiolytic and neuromodulator, has been mapped to this same region of chromosome 4. This study is an advance in genome analyses, demonstrating that crosses between divergent, selectively bred rat lines can be used to identify QTLs. Localization of a gene influencing alcohol consumption may have important implications for the etiology of alcohol abuse and alcoholism in humans. PUBMED: 9660316
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