DESCRIPTION:

Proteins identified by MALDI-TOF mass spectrometry that are regulated in the SFG of alcoholics when compared to controls. Selected proteins with expression changes between alcoholics or controls in either region. Where multiple probe were present the average was taken.

LABEL:

superior frontal gyrus alcoholic

SCORE TYPE:

Effect

DATE ADDED:

2011-06-20

DATE UPDATED:

2024-04-25

SPECIES:

AUTHORS:

Etheridge N, Lewohl JM, Mayfield RD, Harris RA, Dodd PR

TITLE:

Synaptic proteome changes in the superior frontal gyrus and occipital cortex of the alcoholic brain.

JOURNAL:

Proteomics. Clinical applications Jun 2009, Vol 3, pp. 730-742

ABSTRACT:

Cognitive deficits and behavioral changes that result from chronic alcohol abuse are a consequence of neuropathological changes which alter signal transmission through the neural network. To focus on the changes that occur at the point of connection between the neural network cells, synaptosomal preparations from post-mortem human brain of six chronic alcoholics and six non-alcoholic controls were compared using 2D-DIGE. Functionally affected and spared regions (superior frontal gyrus, SFG, and occipital cortex, OC, respectively) were analyzed from both groups to further investigate the specific pathological response that alcoholism has on the brain. Forty-nine proteins were differentially regulated between the SFG of alcoholics and the SFG of controls and 94 proteins were regulated in the OC with an overlap of 23 proteins. Additionally, the SFG was compared to the OC within each group (alcoholics or controls) to identify region specific differences. A selection were identified by MALDI-TOF mass spectrometry revealing proteins involved in vesicle transport, metabolism, folding and trafficking, and signal transduction, all of which have the potential to influence synaptic activity. A number of proteins identified in this study have been previously related to alcoholism; however, the focus on synaptic proteins has also uncovered novel alcoholism-affected proteins. Further exploration of these proteins will illuminate the mechanisms altering synaptic plasticity, and thus neuronal signaling and response, in the alcoholic brain. PUBMED: 19924264
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