GeneSet Information

Tier III GS1262 • Differential expression in traumatic brain injury patients

DESCRIPTION:

Gene expression following traumatic brain injury in humans:Genes differentially expressed in more than one patient

LABEL:

TBI diff expr >1 patient

SCORE TYPE:

Binary

DATE ADDED:

2008-04-22

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Michael DB, Byers DM, Irwin LN

TITLE:

Gene expression following traumatic brain injury in humans: analysis by microarray.

JOURNAL:

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia Apr 2005, Vol 12, pp. 284-90

ABSTRACT:

Global changes in gene expression were analyzed in pericontusional tissue taken during surgery from 4 patients with traumatic brain injury (TBI), in cerebral infarction tissue from a patient with vasculitis and in normal brain tissue resected during craniotomy for meningioma. Of approximately 1,200 genes showing some level of expression by cDNA microarray hybridization, 104 ( approximately 8%) showed differential expression in traumatized tissue. Genes controlling transcriptional regulation, intermediary and energy metabolism, signal transduction, and intercellular adhesion and recognition were differentially affected most often. Four genes previously shown to be associated with TBI (c-Fos, Jun B, HSP70, and Zif/268) were all found to be up-regulated in at least one TBI patient. Thus, the robust response to TBI of several immediate early genes is confirmed, and a longer list of candidate genes from other functional categories is suggested for further studies aimed at understanding the molecular and cellular consequences of TBI. PUBMED: 15851083
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Social Control, Formal (D012926)
Brain (D001921)
Genes, fos (D016762)
Meningioma (D008579)
RNA (D012313)
Humans (D006801)
Craniotomy (D003399)
Patients (D010361)
Comprehension (D032882)
Brain Injuries (D001930)
Alcohol Drinking (D000428)
Adult (D000328)
Genes, Immediate-Early (D017781)
Central Nervous System Depressants (D002492)
Wounds and Injuries (D014947)
HSP70 Heat-Shock Proteins (D018840)
Middle Aged (D008875)
Vasculitis (D014657)
Proto-Oncogene Proteins c-jun (D016755)
Cerebral Infarction (D002544)
Tissues (D014024)
Up-Regulation (D015854)
Oligonucleotide Array Sequence Analysis (D020411)
Early Growth Response Protein 1 (D051766)
Energy Metabolism (D004734)
General Surgery (D013502)
Infarction (D007238)
DNA, Complementary (D018076)
Data Interpretation, Statistical (D003627)
Signal Transduction (D015398)
Cell Cycle (D002453)
Cell Differentiation (D002454)
Ethanol (D000431)
Metabolism (D008660)
Apoptosis (D017209)
brain (MA:0000168)
vasculitis (MP:0001864)
metabolic process (GO:0008152)
transduction (GO:0009293)
signal transduction (GO:0007165)
gene expression (GO:0010467)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351