GeneSet Information

Tier III GS1250 • High-density microarray analysis of hippocampal gene expression following experimental brain injury

DESCRIPTION:

To monitor the expression levels of a large number of genes and to identify genes not previously implicated in traumatic brain injury pathophysiology, a high-density oligonucleotide array containing 8,800 genes was interrogated. RNA samples were prepared from ipsilateral hippocampi 3 hr and 24 hr following lateral cortical impact injury and compared to samples from sham-operated controls.

LABEL:

BrainInjuryDiffExprHPC

SCORE TYPE:

Binary

DATE ADDED:

2008-04-22

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Matzilevich DA, Rall JM, Moore AN, Grill RJ, Dash PK

TITLE:

High-density microarray analysis of hippocampal gene expression following experimental brain injury.

JOURNAL:

Journal of neuroscience research Mar 2002, Vol 67, pp. 646-63

ABSTRACT:

Behavioral, biophysical, and pharmacological studies have implicated the hippocampus in the formation and storage of spatial memory. Traumatic brain injury (TBI) often causes spatial memory deficits, which are thought to arise from the death as well as the dysfunction of hippocampal neurons. Cell death and dysfunction are commonly associated with and often caused by altered expression of specific genes. The identification of the genes involved in these processes, as well as those participating in postinjury cellular repair and plasticity, is important for the development of mechanism-based therapies. To monitor the expression levels of a large number of genes and to identify genes not previously implicated in TBI pathophysiology, a high-density oligonucleotide array containing 8,800 genes was interrogated. RNA samples were prepared from ipsilateral hippocampi 3 hr and 24 hr following lateral cortical impact injury and compared to samples from sham-operated controls. Cluster analysis was employed using statistical algorithms to arrange the genes according to similarity in patterns of expression. The study indicates that the genomic response to TBI is complex, affecting approximately 6% (at the time points examined) of the total number of genes examined. The identity of the genes revealed that TBI affects many aspects of cell physiology, including oxidative stress, metabolism, inflammation, structural changes, and cellular signaling. The analysis revealed genes whose expression levels have been reported to be altered in response to injury as well as several genes not previously implicated in TBI pathophysiology. PUBMED: 11891777
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Annotation Information

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Brain (D001921)
Gene Expression Regulation (D005786)
Cell Physiological Phenomena (D002468)
Animals (D000818)
RNA (D012313)
Memory (D008568)
Physiology (D010827)
Death (D003643)
Blotting, Northern (D015152)
Prostaglandin-Endoperoxide Synthases (D011451)
Rats, Long-Evans (D020318)
Brain Injuries (D001930)
Immunohistochemistry (D007150)
Microarray Analysis (D046228)
RNA, Messenger (D012333)
Wounds and Injuries (D014947)
Neurons (D009474)
Neuronal Plasticity (D009473)
Down-Regulation (D015536)
Time (D013995)
Time Factors (D013997)
Cyclooxygenase 2 (D051546)
Rats (D051381)
Oxidative Stress (D018384)
Up-Regulation (D015854)
Oligonucleotide Array Sequence Analysis (D020411)
Inflammation (D007249)
Cells (D002477)
Memory Disorders (D008569)
Nerve Tissue Proteins (D009419)
Cell Death (D016923)
Isoenzymes (D007527)
Affect (D000339)
Identification (Psychology) (D007062)
Brain-Derived Neurotrophic Factor (D019208)
Algorithms (D000465)
Metabolism (D008660)
Hippocampus (D006624)
Cluster Analysis (D016000)
brain (MA:0000168)
hippocampus (MA:0000191)
oxidative stress (MP:0003674)
abnormal inflammatory response (MP:0001845)
cell death (GO:0008219)
metabolic process (GO:0008152)
cell (GO:0005623)
biosynthetic process (GO:0009058)
cellular process (GO:0009987)
death (GO:0016265)
gene expression (GO:0010467)
memory (GO:0007613)
signaling (GO:0023052)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351

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