DESCRIPTION:

8p21-22 Human Anxiety Disorder

LABEL:

8p21-22 Human Anxiety Disorder

SCORE TYPE:

Binary

DATE ADDED:

2011-02-23

DATE UPDATED:

2020-05-06

SPECIES:

AUTHORS:

Cloninger CR, Van Eerdewegh P, Goate A, Edenberg HJ, Blangero J, Hesselbrock V, Reich T, Nurnberger J Jr, Schuckit M, Porjesz B, Crowe R, Rice JP, Foroud T, Przybeck TR, Almasy L, Bucholz K, Wu W, Shears S, Carr K, Crose C, Willig C, Zhao J, Tischfield JA, Li TK, Conneally PM

TITLE:

Anxiety proneness linked to epistatic loci in genome scan of human personality traits.

JOURNAL:

American journal of medical genetics Jul 1998, Vol 81, pp. 313-7

ABSTRACT:

A genome-wide scan between normal human personality traits and a set of genetic markers at an average interval of 13 centimorgans was carried out in 758 pairs of siblings in 177 nuclear families of alcoholics. Personality traits were measured by the Tridimensional Personality Questionnaire. We detected significant linkage between the trait Harm Avoidance, a measure of anxiety proneness, and a locus on chromosome 8p21-23 that explained 38% of the trait variance. There was significant evidence of epistasis between the locus on 8p and others on chromosomes 18p, 20p, and 21q. These oligogenic interactions explained most of the variance in Harm Avoidance. There was suggestive evidence of epistasis in other personality traits. These results confirm the important influence of epistasis on human personality suggested by twin and adoption studies. PUBMED: 9674977
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