GeneSet Information

Tier III GS1142 • Differential expression among bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum

DESCRIPTION:

Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum

LABEL:

BNST_dStriatum_NucAcc.

SCORE TYPE:

Binary

DATE ADDED:

2008-03-27

DATE UPDATED:

2024-10-22

SPECIES:

AUTHORS:

Olsen CM, Huang Y, Goodwin S, Ciobanu DC, Lu L, Sutter TR, Winder DG

TITLE:

Microarray analysis reveals distinctive signaling between the bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum.

JOURNAL:

Physiological genomics Feb 2008, Vol 32, pp. 283-98

ABSTRACT:

To identify distinct transcriptional patterns between the major subcortical dopamine targets commonly studied in addiction we studied differences in gene expression between the bed nucleus of the stria terminalis (BNST), nucleus accumbens (NAc), and dorsal striatum (dStr) using microarray analysis. We first tested for differences in expression of genes encoding transcripts for common neurotransmitter systems as well as calcium binding proteins routinely used in neuroanatomical delineation of brain regions. This a priori method revealed differential expression of corticotropin releasing hormone (Crh), the GABA transporter (Slc6a1), and prodynorphin (Pdyn) mRNAs as well as several others. Using a gene ontology tool, functional scoring analysis, and Ingenuity Pathway Analysis, we further identified several physiological pathways that were distinct among these brain regions. These two different analyses both identified calcium signaling, G-coupled protein receptor signaling, and adenylate cyclase-related signaling as significantly different among the BNST, NAc, and dStr. These types of signaling pathways play important roles in, amongst other things, synaptic plasticity. Investigation of differential gene expression revealed several instances that may provide insight into reported differences in synaptic plasticity between these brain regions. The results support other studies suggesting that crucial pathways involved in neurotransmission are distinct among the BNST, NAc, and dStr and provide insight into the potential use of pharmacological agents that may target region-specific signaling pathways. Furthermore, these studies provide a framework for future mouse-mouse comparisons of transcriptional profiles after behavioral/pharmacological manipulation. PUBMED: 17911379
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Annotation Information

No sequence read archive data associated with this GeneSet.


Brain (D001921)
Animals (D000818)
Forecasting (D005544)
Play and Playthings (D010988)
Beds (D001513)
Corticotropin-Releasing Hormone (D003346)
Corpus Striatum (D003342)
Mice (D051379)
Gene Regulatory Networks (D053263)
Calcium (D002118)
Gene Expression Profiling (D020869)
Carrier Proteins (D002352)
Calcium Signaling (D020013)
gamma-Aminobutyric Acid (D005680)
Adrenocorticotropic Hormone (D000324)
Microarray Analysis (D046228)
Green Fluorescent Proteins (D049452)
Dopamine (D004298)
Proteins (D011506)
Role (D012380)
Neuronal Plasticity (D009473)
Databases, Factual (D016208)
Septal Nuclei (D012686)
Nucleus Accumbens (D009714)
Oligonucleotide Array Sequence Analysis (D020411)
Mice, Inbred C57BL (D008810)
Neural Pathways (D009434)
Transcription, Genetic (D014158)
Nerve Tissue Proteins (D009419)
Genes, vif (D016341)
Hormones (D006728)
Neurotransmitter Agents (D018377)
Receptors, Neurotransmitter (D017981)
Neurotransmitter Transport Proteins (D050479)
Signal Transduction (D015398)
Genes, Reporter (D017930)
Calcium-Binding Proteins (D002135)
Synaptic Transmission (D009435)
striatum (MA:0000891)
dorsal striatum (MA:0002971)
brain (MA:0000168)
addiction (MP:0002555)
calcium-mediated signaling (GO:0019722)
nascent polypeptide-associated complex (GO:0005854)
nucleus (GO:0005634)
binding (GO:0005488)
gene expression (GO:0010467)
signaling (GO:0023052)

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351

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