DESCRIPTION:
The Inbred Long Sleep (ILS) and Inbred Short Sleep (ISS) mouse strains have a 16-fold difference in duration of loss of the righting response (LORR) following administration of a sedative dose of ethanol. Four quantitative trait loci (QTLs) have been mapped in these strains for this trait. Underlying each of these QTLs must be one or more genetic differences (polymorphisms in either gene coding or regulatory regions) influencing ethanol sensitivity. Genome-wide expression profiling in cerebellum was used to identify candidate genes for regulatory region differences in these two strains. Fifteen differentially expressed genes were found that map to the QTL regions.
LABEL:
UpregISSMapLoreInterval
SCORE TYPE:
Binary
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Uploaded As | Gene Symbol | Homology | Score | Priority | LinkOuts | Emphasis |
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