QTL associated with lung tumor shape-determining 7. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (6659238)
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_subset_pvalue0.05
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated. This dataset only includes a subset of the full dataset, thresholded at p<0.05.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
QTL associated with modifier of polycystic kidney disease progression 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (21827637)
QTL associated with diabetes susceptibility QTL 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (11616475)
Authors:
Moritani M, Togawa K, Yaguchi H, Fujita Y, Yamaguchi Y, Inoue H, Kamatani N, Itakura M
QTL for nicotine sensitivity on Chr16 at D16Mit131 (8.72 Mbp , Build 37)
Description:
nicotine sensitivity spans 0.00 - 33.72 Mbp (NCBI Build 37) on Chr16. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for home cage activity on Chr16 at Comt (22.04 Mbp , Build 37)
Description:
METH responses for home cage activity spans 0.00 - 47.04 Mbp (NCBI Build 37) on Chr16. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL associated with acute functional tolerance to ethanol QTL 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (23737062)
Authors:
Bennett B, Downing C, Carosone-Link P, Ponicsan H, Ruf C, Johnson TE
QTL associated with high density lipoprotein (HDL) level 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (29030158)
Authors:
Mehrabian M, Castellani LW, Wen PZ, Wong J, Rithaporn T, Hama SY, Hough GP, Johnson D, Albers JJ, Mottino GA, Frank JS, Navab M, Fogelman AM, Lusis AJ
QTL associated with lymphoproliferation modifier 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (29030158)
QTL associated with B. burgdorferi-associated arthritis 19. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (13249057)
Authors:
Roper RJ, Weis JJ, McCracken BA, Green CB, Ma Y, Weber KS, Fairbairn D, Butterfield RJ, Potter MR, Zachary JF, Doerge RW, Teuscher C
QTL associated with radiation induced thymic lymphoma susceptibility. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (15913145)
QTL associated with skeletal size (tail length) 7. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (22956575)
QTL associated with skin tumor susceptibility 9. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (22956575)
QTL associated with determination of interleukin 4 commitment 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (11616475)
QTL associated with autoimmune epididymitis resistance 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (5706639)
QTL associated with wound healing/regeneration 11. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (7445973)
Authors:
Heber-Katz E, Leferovich JM, Bedelbaeva K, Gourevitch D
QTL associated with non-HDL QTL 10. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (7445973)
Authors:
Wittenburg H, Lyons MA, Li R, Kurtz U, Wang X, Mssner J, Churchill GA, Carey MC, Paigen B
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