List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Primary biliary cirrhosis. The EFO term biliary liver cirrhosis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
M Nakamura, N Nishida, M Kawashima, Y Aiba, A Tanaka, M Yasunami, H Nakamura, A Komori, M Nakamuta, M Zeniya, E Hashimoto, H Ohira, K Yamamoto, M Onji, S Kaneko, M Honda, S Yamagiwa, K Nakao, T Ichida, H Takikawa, M Seike, T Umemura, Y Ueno, S Sakisaka, K Kikuchi, H Ebinuma, N Yamashiki, S Tamura, Y Sugawara, A Mori, S Yagi, K Shirabe, A Taketomi, K Arai, K Monoe, T Ichikawa, M Taniai, Y Miyake, T Kumagi, M Abe, K Yoshizawa, S Joshita, S Shimoda, K Honda, H Takahashi, K Hirano, Y Takeyama, K Harada, K Migita, M Ito, H Yatsuhashi, N Fukushima, H Ota, T Komatsu, T Saoshiro, J Ishida, H Kouno, H Kouno, M Yagura, M Kobayashi, T Muro, N Masaki, K Hirata, Y Watanabe, Y Nakamura, M Shimada, N Hirashima, T Komeda, K Sugi, M Koga, K Ario, E Takesaki, Y Maehara, S Uemoto, N Kokudo, H Tsubouchi, M Mizokami, Y Nakanuma, K Tokunaga, H Ishibashi
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Ulcerative colitis. The EFO term ulcerative colitis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JZ Liu, S van Sommeren, H Huang, SC Ng, R Alberts, A Takahashi, S Ripke, JC Lee, L Jostins, T Shah, S Abedian, JH Cheon, J Cho, NE Daryani, L Franke, Y Fuyuno, A Hart, RC Juyal, G Juyal, WH Kim, AP Morris, H Poustchi, WG Newman, V Midha, TR Orchard, H Vahedi, A Sood, JJ Sung, R Malekzadeh, HJ Westra, K Yamazaki, SK Yang, JC Barrett, A Franke, BZ Alizadeh, M Parkes, T B K, MJ Daly, M Kubo, CA Anderson, RK Weersma
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Inflammatory bowel disease. The EFO term inflammatory bowel disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JZ Liu, S van Sommeren, H Huang, SC Ng, R Alberts, A Takahashi, S Ripke, JC Lee, L Jostins, T Shah, S Abedian, JH Cheon, J Cho, NE Daryani, L Franke, Y Fuyuno, A Hart, RC Juyal, G Juyal, WH Kim, AP Morris, H Poustchi, WG Newman, V Midha, TR Orchard, H Vahedi, A Sood, JJ Sung, R Malekzadeh, HJ Westra, K Yamazaki, SK Yang, JC Barrett, A Franke, BZ Alizadeh, M Parkes, T B K, MJ Daly, M Kubo, CA Anderson, RK Weersma
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Crohn's disease. The EFO term Crohn's disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JZ Liu, S van Sommeren, H Huang, SC Ng, R Alberts, A Takahashi, S Ripke, JC Lee, L Jostins, T Shah, S Abedian, JH Cheon, J Cho, NE Daryani, L Franke, Y Fuyuno, A Hart, RC Juyal, G Juyal, WH Kim, AP Morris, H Poustchi, WG Newman, V Midha, TR Orchard, H Vahedi, A Sood, JJ Sung, R Malekzadeh, HJ Westra, K Yamazaki, SK Yang, JC Barrett, A Franke, BZ Alizadeh, M Parkes, T B K, MJ Daly, M Kubo, CA Anderson, RK Weersma
Positional candidate genes for HARGREAVES_MEANBOTH in BXD RI Females & Males on Chr4
Description:
Position candidates for HARGREAVES_MEANBOTH measured in BXD RI Females & Males. HARGREAVES_MEANBOTH measures Thermal Nociception Hargreaves' Test under the domain Pain. The QTL found was a Suggestive QTL and spans 44 Mb to 64 Mb.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for ZM_EOPEN measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The ZM_EOPEN measures Zero Maze - total entries in open quadrants under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for HAND_7HOURS measured in BXD RI Females & Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The HAND_7HOURS measures Handling induced convulsions 7 hrs after ethanol under the domain Ethanol HIC. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
The production of 12 out of 27 measured factors was induced by CEsHUT including IL-1β, TNF and IL-1Ra. In contrast to sIL-1Ra production, that of IL-1β and TNF was inhibited by HDL, corroborating previous results. In addition, CEsHUT induced monocytes to produce factors involved in their localization, survival and differentiation such as CCL5 (RANTES), CCL2 (MCP-1), interferon-γ (IFNγ), granulocyte-macrophage colony-stimulating factor (GM-CSF), and macrophage-CSF (M-CSF). The production of the latter was moderate and it was not affected by HDL.
Authors:
Gruaz L, Delucinge-Vivier C, Descombes P, Dayer JM, Burger D
Since HDL preparations may contain several particle subpopulations, we first ascertained that the inhibitory activity of the HDL preparation used in this study was due to apo A–I. As shown in Figure 1Figure 1, the inhibitory activity of HDL was reversed in a dose-dependent manner by antibodies to apo A–I. Antibodies to apo A–I alone did not affect IL-1β and TNF production by human monocytes. Similarly, they did not change CEsHUT-induced production of IL-1β or TNF in the absence of HDL.
Authors:
Gruaz L, Delucinge-Vivier C, Descombes P, Dayer JM, Burger D
cocaine related behavior 5 (Cocrb5) spans 57.11978 - 107.11978 Mbp (NCBI Build 37) on Chr 4. Obtained from MGI (http://www.informatics.jax.org) by searching for QTLs containing the keyword .
QTL for METH responses for body temperature on Chr4 at D4Nds8 (40.90 Mbp , Build 37)
Description:
METH responses for body temperature spans 15.90 - 65.90 Mbp (NCBI Build 37) on Chr4. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for chewing on Chr4 at Lyb4 (46.47 Mbp , Build 37)
Description:
METH responses for chewing spans 21.47 - 71.47 Mbp (NCBI Build 37) on Chr4. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
cocaine related behavior spans 61.29 - 111.29 Mbp (NCBI Build 37) on Chr4. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for alcohol withdrawal on Chr4 at D4Mit79 (84.39 Mbp , Build 37)
Description:
alcohol withdrawal spans 59.39 - 109.39 Mbp (NCBI Build 37) on Chr4. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for climbing on Chr4 at Ms6hm (85.41 Mbp , Build 37)
Description:
METH responses for climbing spans 60.41 - 110.41 Mbp (NCBI Build 37) on Chr4. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Genes associated with Homo sapiens that interact with the MeSH term 'Arsenic' (D001151). Incorporates data from 87 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term '(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine' (C516138). Incorporates data from 3 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Cloxacillin' (D003023). Incorporates data from 121 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Clozapine' (D003024). Incorporates data from 2 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Tretinoin' (D014212). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Platichthys flesus that interact with the MeSH term 'pentabromodiphenyl ether' (C086401). Incorporates data from 4 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'geldanamycin' (C001277). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Cadmium' (D002104). Incorporates data from 7 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Testosterone' (D013739). Incorporates data from 4 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Testolactone' (D013738). Incorporates data from 1377 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
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