Cerebellum Gene Expression Correlates for PTOSIS measured in BXD RI Females obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The PTOSIS measures Morphine - Severity of ptosis under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
QTL for METH responses for home cage activity on Chr14 at Gnrh (75.38 Mbp , Build 37)
Description:
METH responses for home cage activity spans 50.38 - 100.38 Mbp (NCBI Build 37) on Chr14. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for chronic alcohol withdrawal severity on Chr14 at D14mit160 (75.81 Mbp , Build 37)
Description:
chronic alcohol withdrawal severity spans 50.81 - 100.81 Mbp (NCBI Build 37) on Chr14. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Bergeson SE, Kyle Warren R, Crabbe JC, Metten P, Gene Erwin V, Belknap JK
QTL for METH responses for climbing on Chr14 at Es10 (78.19 Mbp , Build 37)
Description:
METH responses for climbing spans 53.19 - 103.19 Mbp (NCBI Build 37) on Chr14. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for nicotine sensitivity on Chr14 at D14Mit165 (103.63 Mbp , Build 37)
Description:
nicotine sensitivity spans 78.63 - 128.63 Mbp (NCBI Build 37) on Chr14. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL associated with heart weight quantitative locus 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (73709112)
Authors:
Sugiyama F, Churchill GA, Li R, Libby LJ, Carver T, Yagami K, John SW, Paigen B
QTL associated with lymphoproliferation modifier 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (88383595)
QTL associated with modifier of ocular retardation 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (74651432)
QTL associated with osteosarcoma susceptibility 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (91557327)
Authors:
Rosemann M, Kuosaite V, Kremer M, Favor J, Quintanilla-Martinez L, Atkinson MJ
QTL associated with proteoglycan induced arthritis 29. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (91514647)
Authors:
Glant TT, Adarichev VA, Nesterovitch AB, Szanto S, Oswald JP, Jacobs JJ, Firneisz G, Zhang J, Finnegan A, Mikecz K
QTL associated with total body bone mineral density 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (94235479)
Authors:
Masinde GL, Li X, Gu W, Wergedal J, Mohan S, Baylink DJ
QTL associated with vertebral morphology and mechanical traits 10. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (106665012)
Authors:
Reeves GM, McCreadie BR, Chen S, Galecki AT, Burke DT, Miller RA, Goldstein SA
QTL associated with vertebral morphology and mechanical traits 11. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (89360701)
Authors:
Reeves GM, McCreadie BR, Chen S, Galecki AT, Burke DT, Miller RA, Goldstein SA
Genes with particular expression in the Anterior olfactory nucleus, dorsal part. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Cortical amygdalar area, posterior part, lateral zone, layer 3. Data represent fold expression difference in structure versus grey matter average expression.
Alcohol transcriptome changes in mice microglia total homogenate p-value
Description:
Microglia are fundamentally important immune cells within the central nervous system (CNS) that respond to environmental challenges to maintain normal physiological processes. Alterations in steady-state cellular function and over-activation of microglia can facilitate the initiation and progression of neuropathological conditions such as Alzheimer’s disease, Multiple Sclerosis, and Major Depressive Disorder. Alcohol consumption disrupts signaling pathways including both innate and adaptive immune responses that are necessary for CNS homeostasis. Coordinate expression of these genes is not ascertained from an admixture of CNS cell-types, underscoring the importance of examining isolated cellular populations to reveal systematic gene expression changes arising from mature microglia. Unbiased RNA-Seq profiling was used to identify gene expression changes in isolated prefrontal cortical microglia in response to recurring bouts of voluntary alcohol drinking behavior. The voluntary ethanol paradigm utilizes long-term consumption ethanol that results in escalated alcohol intake and altered cortical plasticity that is seen in humans. Gene coexpression analysis identified a coordinately regulated group of genes, unique to microglia, that collectively are associated with alcohol consumption. Genes within this group are involved in toll-like receptor signaling and transforming growth factor beta signaling. Network connectivity of this group identified Siglech as a putative hub gene and highlighted the potential importance of proteases in the microglial response to chronic ethanol. In conclusion, we identified a distinctive microglial gene expression signature for neuroimmune responses related to alcohol consumption that provides valuable insight into microglia-specific changes underlying the development of substance abuse, and possibly other CNS disorders.
Authors:
Gizelle M McCarthy, Sean P Farris, Yuri A Blednov, R Adron Harris, R Dayne Mayfield
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