Tier
Species
Size
Attr.
GeneSet
Tier IV
23905
GS408379: Differential gene expression in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine in mice_pvalue
Figure Label:
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
Tier IV
51914
GS405734: WWP1 KO vs WT
Figure Label:
WWP1
Description:
To see gene sets category
Authors:
Tier II
1994
GS223048: Hepatocarcinoma susceptibility QTL 2 (Hcas2 Published QTL Chr 1)
Figure Label:
QTL-Hcas2-Rat-Chr 1
Description:
QTL Associated with Liver tumor susceptibility. On Chromosome 1 with a LOD score= 3, p-value =1.00E-04. From a(n) of BNxF344
Authors:
De Miglio MR, Canzian F, Pascale RM, Simile MM, Muroni MR, Calvisi D, Romeo G, Feo F
Tier II
613
GS223099: Blood pressure QTL 145 (Bp145 Published QTL Chr 1)
Figure Label:
QTL-Bp145-Rat-Chr 1
Description:
QTL Associated with Blood pressure. On Chromosome 1 with a LOD score= 2.1, p-value =0.0024. From a(n) intercross of MWF/RkbxLEW/Rkb
Authors:
Schulz A, Litfin A, Kossmehl P, Kreutz R
Tier II
1234
GS223252: Bone mineral density QTL 73 (Bmd73 Published QTL Chr 1)
Figure Label:
QTL-Bmd73-Rat-Chr 1
Description:
QTL Associated with Bone mineral density. On Chromosome 1 with a LOD score= 3.9, p-value =1.00E-04. From a(n) intercross of
Authors:
Lagerholm S, Li LS, Jiao H, Park HB, Ohlsson C, Akesson K, Luthman H
Tier II
1234
GS223253: Bone mineral density QTL 72 (Bmd72 Published QTL Chr 1)
Figure Label:
QTL-Bmd72-Rat-Chr 1
Description:
QTL Associated with Bone mineral density. On Chromosome 1 with a LOD score= 2.5, p-value =1.00E-04. From a(n) intercross of
Authors:
Lagerholm S, Li LS, Jiao H, Park HB, Ohlsson C, Akesson K, Luthman H
Tier II
1234
GS223254: Bone structure and strength QTL 67 (Bss67 Published QTL Chr 1)
Figure Label:
QTL-Bss67-Rat-Chr 1
Description:
QTL Associated with Bone structure. On Chromosome 1 with a LOD score= 3.1, p-value =1.00E-04. From a(n) intercross of
Authors:
Lagerholm S, Li LS, Jiao H, Park HB, Ohlsson C, Akesson K, Luthman H
Tier II
1234
GS223255: Bone structure and strength QTL 66 (Bss66 Published QTL Chr 1)
Figure Label:
QTL-Bss66-Rat-Chr 1
Description:
QTL Associated with Bone structure. On Chromosome 1 with a LOD score= 3.4, p-value =1.00E-04. From a(n) intercross of
Authors:
Lagerholm S, Li LS, Jiao H, Park HB, Ohlsson C, Akesson K, Luthman H
Tier II
1439
GS223302: Bone mineral density QTL 1 (Bmd1 Published QTL Chr 1)
Figure Label:
QTL-Bmd1-Rat-Chr 1
Description:
QTL Associated with Bone mineral density. On Chromosome 1 with a LOD score= 12.2, p-value =1.00E-04. From a(n) of
Authors:
Koller DL, Alam I, Sun Q, Liu L, Fishburn T, Carr LG, Econs MJ, Foroud T, Turner CH
Tier II
1350
GS223341: Experimental allergic encephalomyelitis QTL 29 (Eae29 Published QTL Chr 1)
Figure Label:
QTL-Eae29-Rat-Chr 1
Description:
QTL Associated with Brain/spinal cord inflammation. On Chromosome 1 with a LOD score= 5.51, p-value =. From a(n) of
Authors:
Beyeen AD, Adzemovic MZ, Ockinger J, Stridh P, Becanovic K, Laaksonen H, Lassmann H, Harris RA, Hillert J, Alfredsson L, Celius EG, Harbo HF, Kockum I, Jagodic M, Olsson T
Tier II
1234
GS224178: Bone structure and strength QTL 69 (Bss69 Published QTL Chr 1)
Figure Label:
QTL-Bss69-Rat-Chr 1
Description:
QTL Associated with Bone strength. On Chromosome 1 with a LOD score= 3.5, p-value =1.00E-04. From a(n) intercross of
Authors:
Lagerholm S, Li LS, Jiao H, Park HB, Ohlsson C, Akesson K, Luthman H
Tier II
970
GS224471: Heart rate QTL 2 (Hrtrt2 Published QTL Chr 1)
Figure Label:
QTL-Hrtrt2-Rat-Chr 1
Description:
QTL Associated with Heart rate. On Chromosome 1 with a LOD score= 4.35, p-value =. From a(n) of
Authors:
Moreno C, Dumas P, Kaldunski ML, Tonellato PJ, Greene AS, Roman RJ, Cheng Q, Wang Z, Jacob HJ, Cowley AW Jr
Tier II
1234
GS224505: Bone structure and strength QTL 68 (Bss68 Published QTL Chr 1)
Figure Label:
QTL-Bss68-Rat-Chr 1
Description:
QTL Associated with Bone structure. On Chromosome 1 with a LOD score= 2.9, p-value =1.00E-04. From a(n) intercross of
Authors:
Lagerholm S, Li LS, Jiao H, Park HB, Ohlsson C, Akesson K, Luthman H
Tier II
1234
GS224794: Bone structure and strength QTL 70 (Bss70 Published QTL Chr 1)
Figure Label:
QTL-Bss70-Rat-Chr 1
Description:
QTL Associated with Bone strength. On Chromosome 1 with a LOD score= 3.5, p-value =1.00E-04. From a(n) intercross of
Authors:
Lagerholm S, Li LS, Jiao H, Park HB, Ohlsson C, Akesson K, Luthman H
Tier II
760
GS224658: Pristane induced arthritis QTL 8 (Pia8 Published QTL Chr 1)
Figure Label:
QTL-Pia8-Rat-Chr 1
Description:
QTL Associated with Joint/bone inflammation. On Chromosome 1 with a LOD score= 4.7, p-value =. From a(n) intercross of
Authors:
Nordquist N, Olofsson P, Vingsbo-Lundberg C, Petterson U, Holmdahl R
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