The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
QTL for nicotine sensitivity on Chr8 at D8Mit124 (13.44 Mbp , Build 37)
Description:
nicotine sensitivity spans 0.00 - 38.44 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
alcohol preference spans 0.00 - 40.29 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Bachmanov AA, Reed DR, Li X, Li S, Beauchamp GK, Tordoff MG
QTL for METH responses for home cage activity on Chr8 at D8Bir2 (25.76 Mbp , Build 37)
Description:
METH responses for home cage activity spans 0.76 - 50.76 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
chronic alcohol withdrawal severity spans 1.57 - 51.57 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Bergeson SE, Kyle Warren R, Crabbe JC, Metten P, Gene Erwin V, Belknap JK
QTL for differences in cocaine responsiveness on Chr8 at D8MIt8 (53.66 Mbp , Build 37)
Description:
differences in cocaine responsiveness spans 28.66 - 78.66 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL associated with Alzheimer's disease modifier 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (27830259)
Authors:
Sebastiani G, Krzywkowski P, Dudal S, Yu M, Paquette J, Malo D, Gervais F, Tremblay P
QTL associated with directional asymmetry QTL 19. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (33127016)
QTL associated with experimental allergic encephalomyelitis susceptibility 14. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (37050918)
QTL associated with experimental allergic encephalomyelitis susceptibility 24. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25723657)
QTL associated with lung tumor shape-determining 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25723657)
QTL associated with macrophage-associated risk inflammatory factor 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (35916997)
QTL associated with nicotine induced locomotor activity 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (14723160)
QTL associated with platelet-binding antibody-associated thrombocytopenia 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (30715154)
Authors:
Ida A, Hirose S, Hamano Y, Kodera S, Jiang Y, Abe M, Zhang D, Nishimura H, Shirai T
QTL associated with proteoglycan induced arthritis 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (34189817)
Authors:
Glant TT, Adarichev VA, Nesterovitch AB, Szanto S, Oswald JP, Jacobs JJ, Firneisz G, Zhang J, Finnegan A, Mikecz K
QTL associated with proteinuria 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (37050918)
Authors:
Kim EH, Lee CH, Hyun BH, Suh JG, Oh YS, Namikawa T, Ishikawa A
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