List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Periodontal disease-related phenotypes. The EFO term periodontitis, periodontal measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
S Offenbacher, K Divaris, SP Barros, KL Moss, JT Marchesan, T Morelli, S Zhang, S Kim, L Sun, JD Beck, M Laudes, M Munz, AS Schaefer, KE North
Differentially expressed genes from RPE compared to Normal Retina
Description:
Transcriptome profiling from macular retina and RPE/choroid samples from 27 unrelated eye tissue donors, was performed using RNA-sequencing. Human donor eye collection were obtained from Utah Lions Eye Bank within a 6-hour post-mortem interval and donors aged 60-90 years. Sample types were Normal Retina, Intermediate AMD Retina, Neovascular AMD Retina, Normal macular retina pigment epithelium (RPE), Intermediate AMD RPE, and Neovascular AMD RPE. Age Related Macular Degeneration (AMD) phenotyping was determined using the Age-Related Eye Disease Study (AREDS) severity grading scale, where AREDS category 0/1 was considered normal, AREDS category 3 intermediate AMD, and AREDS category 4b neovascular AMD. Samples from Normal RPE were compared to Normal Retina, and are presented with fold change > 1.5 and and P < 0.05. This gene set was annotated from the Supplementry Table of BioRxiv pre-print paper ‘Patterns of gene expression and allele-specific expression vary among macular tissues and clinical stages of Age-related Macular Degeneration’ by Zhang et.al (2022) doi: https://doi.org/10.1101/2022.12.19.521092
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Sjögren's syndrome. The EFO term Sjogren syndrome was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
IW Song, HC Chen, YF Lin, JH Yang, CC Chang, CT Chou, MM Lee, YC Chou, CH Chen, YT Chen, CH Chen, JY Wu
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Night sleep phenotypes. The EFO term sleep quality was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Spada, M Scholz, H Kirsten, T Hensch, K Horn, P Jawinski, C Ulke, R Burkhardt, K Wirkner, M Loeffler, U Hegerl, C Sander
Dysregulation of NRSF/REST via EHMT1 is associated with psychiatric disorders and Kleefstra syndrome, Z scores
Description:
EHMT1 is an epigenetic repressor that is causal for Kleefstra Syndrome (KS), a neurodevelopmental disorder (NDD) leading to intelectual disability, and is associated with schizophrenia. Here, the researchers aim to show we show that reduced EHMT1 activity decreases NRSF/REST protein leading to abnormal neuronal gene expression and progression of neurodevelopment in human iPSC. Five induced pluripotent stem cell samples (from fibroblasts of adult, male, skin) were used. The stem cells were gifted from: Lieber Institute for Brain Development, Johns Hopkins Medical Campus. Total RNA extracted from a control hiPSC line and control cells treated for 72h with various concentrations of UNC0638 i.e 50, 100, 200 or 250nM as a model for Kleefstra syndrome. Polyadenylated adaptors were ligated to the 3′-end, 5′-adaptors were then ligated, and the resulting RNAs were reverse transcribed to generate cDNA that can be amplified by PCR. The amplified product was run on low range ultra agarose in TBE buffer and a size-selection was performed to ensure that the cDNA used for sequencing primarily contains miRNAs rather than other RNA contaminants. Expression values were calculated by the method detailed in 'HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis' (Genome Biol. 2020, PMID: 32660516), and Z scores calculated. Genes were annotated as Ensembl gene ids. SRA Study id ERP130338.
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
DEG human CN astrocytes CocUD vs control_avg log2FC
Description:
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
DEG human CN microglia CocUD vs control_avg log2FC
Description:
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
DEG human CN oligodendrocytes CocUD vs control_pvalue
Description:
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
DEG human CN oligodendrocytes CocUD vs control_avg log2FC
Description:
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
DEG human CN oligodendrocytes CocUD vs control_qvalue
Description:
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
We performed single-nuclei multiome profiling on postmortem caudate nucleus (CN) tissue from six individuals with cocaine use disorder (CocUD) and eight controls, all of African American ancestry. CocUD cases and controls were balanced according to age and sex. We performed single-nuclei ATAC-seq and RNA-seq using the 10x Genomics Multiome platform. Weighted nearest neighbor analysis resulted in an integrated UMAP depicting 13 clearly delineated cell types, including astrocytes, microglia, oligodendrocytes, oligodendrocyte precursor cells (OPC), endothelial cells and lymphocytes, as well as different GABAergic neurons, such as D1 and D2 medium spiny neurons (MSNs) and a small population of cholinergic neurons.
Authors:
Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja Völker, Svenja Müller, Anita Hansson, Thomas Meyer, Marcella Rietschel, Rainer Spanagel, Ana Oliveira, Consuelo Walss-Bass, Rick Bernardi, Philipp Koch, Stephanie Witt
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Breast size. The EFO term breast size, breast carcinoma was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
N Eriksson, GM Benton, CB Do, AK Kiefer, JL Mountain, DA Hinds, U Francke, JY Tung
Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use disorder. Transcriptomic profile of 20 control subjects and 20 OUD subjects in brain region DLPFC and NAC. Analyzed using GEO2R (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174409) separately for each brain region, comparing OUD and control samples.
Authors:
Xiangning Xue, Wei Zong, Jill R Glausier, Sam-Moon Kim, Micah A Shelton, BaDoi N Phan, Chaitanya Srinivasan, Andreas R Pfenning, George C Tseng, David A Lewis, Marianne L Seney, Ryan W Logan
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