GWAS: diabetes mellitus, urinary albumin to creatinine ratio
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Urinary albumin-to-creatinine ratio in diabetes. The EFO term diabetes mellitus, urinary albumin to creatinine ratio was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Teumer, A Tin, R Sorice, M Gorski, NC Yeo, AY Chu, M Li, Y Li, V Mijatovic, YA Ko, D Taliun, A Luciani, MH Chen, Q Yang, MC Foster, M Olden, LT Hiraki, BO Tayo, C Fuchsberger, AK Dieffenbach, AR Shuldiner, AV Smith, AM Zappa, A Lupo, B Kollerits, B Ponte, B Stengel, BK Krämer, B Paulweber, BD Mitchell, C Hayward, C Helmer, C Meisinger, C Gieger, CM Shaffer, C Müller, C Langenberg, D Ackermann, D Siscovick, E Boerwinkle, F Kronenberg, GB Ehret, G Homuth, G Waeber, G Navis, G Gambaro, G Malerba, G Eiriksdottir, G Li, HE Wichmann, H Grallert, H Wallaschofski, H Völzke, H Brenner, H Kramer, I Mateo Leach, I Rudan, HL Hillege, JS Beckmann, JC Lambert, J Luan, JH Zhao, J Chalmers, J Coresh, JC Denny, K Butterbach, LJ Launer, L Ferrucci, L Kedenko, M Haun, M Metzger, M Woodward, MJ Hoffman, M Nauck, M Waldenberger, M Pruijm, M Bochud, M Rheinberger, N Verweij, NJ Wareham, N Endlich, N Soranzo, O Polasek, P van der Harst, PP Pramstaller, P Vollenweider, PS Wild, RT Gansevoort, R Rettig, R Biffar, RJ Carroll, R Katz, RJ Loos, SJ Hwang, S Coassin, S Bergmann, SE Rosas, S Stracke, TB Harris, T Corre, T Zeller, T Illig, T Aspelund, T Tanaka, U Lendeckel, U Völker, V Gudnason, V Chouraki, W Koenig, Z Kutalik, JR O'Connell, A Parsa, IM Heid, AD Paterson, IH de Boer, O Devuyst, J Lazar, K Endlich, K Susztak, J Tremblay, P Hamet, HJ Jacob, CA Böger, CS Fox, C Pattaro, A Köttgen
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Urinary albumin-to-creatinine ratio. The EFO term urinary albumin to creatinine ratio was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Teumer, A Tin, R Sorice, M Gorski, NC Yeo, AY Chu, M Li, Y Li, V Mijatovic, YA Ko, D Taliun, A Luciani, MH Chen, Q Yang, MC Foster, M Olden, LT Hiraki, BO Tayo, C Fuchsberger, AK Dieffenbach, AR Shuldiner, AV Smith, AM Zappa, A Lupo, B Kollerits, B Ponte, B Stengel, BK Krämer, B Paulweber, BD Mitchell, C Hayward, C Helmer, C Meisinger, C Gieger, CM Shaffer, C Müller, C Langenberg, D Ackermann, D Siscovick, E Boerwinkle, F Kronenberg, GB Ehret, G Homuth, G Waeber, G Navis, G Gambaro, G Malerba, G Eiriksdottir, G Li, HE Wichmann, H Grallert, H Wallaschofski, H Völzke, H Brenner, H Kramer, I Mateo Leach, I Rudan, HL Hillege, JS Beckmann, JC Lambert, J Luan, JH Zhao, J Chalmers, J Coresh, JC Denny, K Butterbach, LJ Launer, L Ferrucci, L Kedenko, M Haun, M Metzger, M Woodward, MJ Hoffman, M Nauck, M Waldenberger, M Pruijm, M Bochud, M Rheinberger, N Verweij, NJ Wareham, N Endlich, N Soranzo, O Polasek, P van der Harst, PP Pramstaller, P Vollenweider, PS Wild, RT Gansevoort, R Rettig, R Biffar, RJ Carroll, R Katz, RJ Loos, SJ Hwang, S Coassin, S Bergmann, SE Rosas, S Stracke, TB Harris, T Corre, T Zeller, T Illig, T Aspelund, T Tanaka, U Lendeckel, U Völker, V Gudnason, V Chouraki, W Koenig, Z Kutalik, JR O'Connell, A Parsa, IM Heid, AD Paterson, IH de Boer, O Devuyst, J Lazar, K Endlich, K Susztak, J Tremblay, P Hamet, HJ Jacob, CA Böger, CS Fox, C Pattaro, A Köttgen
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Microalbuminuria. The EFO term Microalbuminuria was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Teumer, A Tin, R Sorice, M Gorski, NC Yeo, AY Chu, M Li, Y Li, V Mijatovic, YA Ko, D Taliun, A Luciani, MH Chen, Q Yang, MC Foster, M Olden, LT Hiraki, BO Tayo, C Fuchsberger, AK Dieffenbach, AR Shuldiner, AV Smith, AM Zappa, A Lupo, B Kollerits, B Ponte, B Stengel, BK Krämer, B Paulweber, BD Mitchell, C Hayward, C Helmer, C Meisinger, C Gieger, CM Shaffer, C Müller, C Langenberg, D Ackermann, D Siscovick, E Boerwinkle, F Kronenberg, GB Ehret, G Homuth, G Waeber, G Navis, G Gambaro, G Malerba, G Eiriksdottir, G Li, HE Wichmann, H Grallert, H Wallaschofski, H Völzke, H Brenner, H Kramer, I Mateo Leach, I Rudan, HL Hillege, JS Beckmann, JC Lambert, J Luan, JH Zhao, J Chalmers, J Coresh, JC Denny, K Butterbach, LJ Launer, L Ferrucci, L Kedenko, M Haun, M Metzger, M Woodward, MJ Hoffman, M Nauck, M Waldenberger, M Pruijm, M Bochud, M Rheinberger, N Verweij, NJ Wareham, N Endlich, N Soranzo, O Polasek, P van der Harst, PP Pramstaller, P Vollenweider, PS Wild, RT Gansevoort, R Rettig, R Biffar, RJ Carroll, R Katz, RJ Loos, SJ Hwang, S Coassin, S Bergmann, SE Rosas, S Stracke, TB Harris, T Corre, T Zeller, T Illig, T Aspelund, T Tanaka, U Lendeckel, U Völker, V Gudnason, V Chouraki, W Koenig, Z Kutalik, JR O'Connell, A Parsa, IM Heid, AD Paterson, IH de Boer, O Devuyst, J Lazar, K Endlich, K Susztak, J Tremblay, P Hamet, HJ Jacob, CA Böger, CS Fox, C Pattaro, A Köttgen
Striatum Gene Expression Correlates for AMDIST30 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The AMDIST30 measures Morphine distance (cm) travelled minutes 15-30 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for AMDIST45 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The AMDIST45 measures Morphine distance (cm) travelled minutes 30-45 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for AMDIST60 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The AMDIST60 measures Morphine distance (cm) travelled minutes 45-60 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for AMDIST75 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The AMDIST75 measures Morphine distance (cm) travelled minutes 60-75 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for AMDIST90 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The AMDIST90 measures Morphine distance (cm) travelled minutes 75-90 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for MORPH_ADIST_2 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The MORPH_ADIST_2 measures Morphine Open Field TOTAL distance (cm) travelled under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for PTOSIS measured in BXD RI Females obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The PTOSIS measures Morphine - Severity of ptosis under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for SPD_TIMEDOWEL30SEC measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The SPD_TIMEDOWEL30SEC measures Dowel Test - Time 30 Sec under the domain Porsolt. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for SPD_TIMEIMMOBILE measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The SPD_TIMEIMMOBILE measures Porsolt Time Immobile under the domain Porsolt. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
The production of 12 out of 27 measured factors was induced by CEsHUT including IL-1β, TNF and IL-1Ra. In contrast to sIL-1Ra production, that of IL-1β and TNF was inhibited by HDL, corroborating previous results. In addition, CEsHUT induced monocytes to produce factors involved in their localization, survival and differentiation such as CCL5 (RANTES), CCL2 (MCP-1), interferon-γ (IFNγ), granulocyte-macrophage colony-stimulating factor (GM-CSF), and macrophage-CSF (M-CSF). The production of the latter was moderate and it was not affected by HDL.
Authors:
Gruaz L, Delucinge-Vivier C, Descombes P, Dayer JM, Burger D
QTL for ethanol conditioned taste aversion on Chr7 at D7Ncvs57 (73.76 Mbp , Build 37)
Description:
ethanol conditioned taste aversion spans 48.76 - 98.76 Mbp (NCBI Build 37) on Chr7. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for alcohol preference locus on Chr7 at D7Mit19 (85.32 Mbp , Build 37)
Description:
alcohol preference locus spans 60.32 - 110.32 Mbp (NCBI Build 37) on Chr7. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for nicotine sensitivity on Chr7 at D7Mit66 (116.91 Mbp , Build 37)
Description:
nicotine sensitivity spans 91.91 - 141.91 Mbp (NCBI Build 37) on Chr7. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Chronic cocaine - Cocaine-paired (conditioned place preference) vs. Control (saline or cocaine-non-paired) DNA microarray All genes on microarray presented After the pre-conditioning phase where animals were allowed access to either compartment for 15 minutes for 4 consecutive days, the conditioning phase for the cocaine-paired groups and cocaine non-paired groups began, consisting of eight subsequent daily sessions. For both groups, cocaine (10 mg / kg) or saline injections were administered on alternate days. For the cocaine-paired groups, rats were immediately placed in one of the two compartments for 30 min with the door in place restricting a z transformation followed by z test and anova followed by Student-Newman-Keuls' post hoc test. Gene expression profile was assessed 24 h after the last conditioning session that corresponded to 48 h after last cocaine exposure, when drug has been eliminated from the body and transient transcriptional changes are likely to be minimal. Therefore, changes in gene expression at this time-point are likely to reflect longer lasting adaptations that may account for maintenance of cocaine-induced memories. The complete lists of normalized gene expression values for the hippocampus of saline-treated, cocaine non-paired and cocaine-paired groups are presented. Analyses revealed that 214 transcripts were differentially regulated in the hippocampus of cocaine-paired rats vs. non-paired and saline-treated controls. Cocaine-induced conditioned place preference caused significant increases in the expression of 151 genes and caused decreases in the expression of 63 genes. (NIF Table ID 130.1 [83])
Authors:
Krasnova IN, Li SM, Wood WH, McCoy MT, Prabhu VV, Becker KG, Katz JL, Cadet JL
Chronic cocaine - Cocaine-paired (conditioned place preference) vs. Control (saline or cocaine-non-paired) DNA microarray All genes on microarray presented After the pre-conditioning phase where animals were allowed access to either compartment for 15 minutes for 4 consecutive days, the conditioning phase for the cocaine-paired groups and cocaine non-paired groups began, consisting of eight subsequent daily sessions. For both groups, cocaine (10 mg / kg) or saline injections were administered on alternate days. For the cocaine-paired groups, rats were immediately placed in one of the two compartments for 30 min with the door in place restricting a z transformation followed by z test and anova followed by Student-Newman-Keuls' post hoc test. Gene expression profile was assessed 24 h after the last conditioning session that corresponded to 48 h after last cocaine exposure, when drug has been eliminated from the body and transient transcriptional changes are likely to be minimal. Therefore, changes in gene expression at this time-point are likely to reflect longer lasting adaptations that may account for maintenance of cocaine-induced memories. The complete lists of normalized gene expression values for the frontal cortex of saline-treated, cocaine non-paired and cocaine-paired groups are presented. Differences in the expression of 39 transcripts in the frontal cortex were related to the conditioned place preference paradigm. These include increases in the level of 22 genes and decreases in 17 genes. (NIF Table ID 130.3 [83.5])
Authors:
Krasnova IN, Li SM, Wood WH, McCoy MT, Prabhu VV, Becker KG, Katz JL, Cadet JL
Genes associated with Homo sapiens that interact with the MeSH term '(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine' (C516138). Incorporates data from 3 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Sus scrofa that interact with the MeSH term 'Dietary Fats' (D004041). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'resveratrol' (C059514). Incorporates data from 16 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'vorinostat' (C111237). Incorporates data from 13 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Aflatoxin B1' (D016604). Incorporates data from 5 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'potassium chromate(VI)' (C027373). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
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