Differentially expressed geens in the central amygdala (CeA) of male Sprague-Dawley rats (300-350 g prior to surgery, 325-375 g at start of self-administration) on day 2 following methamphetamine withdrawal. Gene Expression was evaluated via RNA-seq. Data taken from Supplementary Table S2. Values presented are adjusted p-values. Data available from GEO with accession number GSE111243."
Authors:
Hannah M Cates, Xuan Li, Immanuel Purushothaman, Pamela J Kennedy, Li Shen, Yavin Shaham, Eric J Nestler
QTL associated with determination of interleukin 4 commitment 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (136360966)
Genes associated with Rattus norvegicus that interact with the MeSH term '2,2',4,4'-tetrabromodiphenyl ether' (C511295). Incorporates data from 4 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Rattus norvegicus that interact with the MeSH term 'spiro(imidazo-(1,2-a)pyridine-3,2-indan)-2(3H)-one' (C511224). Incorporates data from 838 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Epigenetic effects of paternal cocaine on accumbens gene expression in mice_p-value
Description:
This study, utilizing a murine (C57BL/6J) oral cocaine model, examines the effects of paternal cocaine exposure on fundamental characteristics of offspring reward responses, including: 1) the extent of cocaine-induced effects after different durations of sire drug withdrawal; 2) sex- and drug-dependent differences in F1 reward preference; 3) effects on second generation (F2) cocaine preference; and 4) corresponding changes in reward area (nucleus accumbens) mRNA expression. We demonstrate that paternal cocaine intake over a single Ëœ40-day spermatogenic cycle significantly decreased cocaine (but not ethanol or sucrose) preference in a sex-specific manner in F1 mice from sires mated 24 h after drug withdrawal. However, F1 offspring of sires bred 4 months after withdrawal did not exhibit altered cocaine preference. Altered cocaine preference also was not observed in F2′s. RNASeq analyses of F1 accumbens tissue revealed changes in gene expression in male offspring of cocaine-exposed sires, including many genes not previously linked to cocaine addiction.Â
Authors:
Alexandra M Yaw, Rebecca A Prosser, Piet C Jones, Benjamin J Garcia, Daniel A Jacobson, J David Glass
QTL associated with macrophage-associated risk inflammatory factor 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (35916997)
Genes associated with nan that interact with the MeSH term '3-(2-benzyloxyphenyl)-5-chloromethylisoxazole' (C584469). Incorporates data from 1892 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes with particular expression in the Agranular insular area, posterior part, layer 2/3. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Lateral visual area, layer 2/3. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Temporal association areas, layer 2/3. Data represent fold expression difference in structure versus grey matter average expression.
A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic.
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QTL Associated with Insulin level. On Chromosome 3 with a LOD score= 4.4, p-value =0.0016. From a(n) intercross of QTL Associated with Renal function. On Chromosome 1 with a LOD score= 2.91, p-value =. From a(n) intercross of SD/GHSxWKY
Authors:
Hoopes RR Jr, Reid R, Sen S, Szpirer C, Dixon P, Pannett AA, Thakker RV, Bushinsky DA, Scheinman SJ
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