Genes with particular expression in the Parastrial nucleus. Data represent fold expression difference in structure versus grey matter average expression.
The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
Ethanol Induced Hypothermia Chr# 7 rs13479153(25722935) with right flanking marker rs3700068(4187548) and left marker rs3716088(140189839). This was mapped in 300 + (b6x129)F2 mice.
Average rotarod training latency Chr# 7 mCV23423763(68111945) with right flanking marker rs3700068(4187548) and left marker rs3663988(146505067). This was mapped in 300 + (b6x129)F2 mice.
Rotarod Baseline Chr# 7 rs4226783(100081465) with right flanking marker rs8260975(53682778) and left marker rs13479506 (131822778). This was mapped in 300 + (b6x129)F2 mice.
QTL Associated with Activity level. On Chromosome 5 with a LOD score= , p-value =2.00E-04. From a(n) of QTL Associated with Gland mass. On Chromosome 1 with a LOD score= 7.82, p-value =0.001. From a(n) backcross of BUF/MnaxMITE/Mna
QTL Associated with subcutaneous adipose mass. On Chromosome 17 with a LOD score= 8.62, p-value =0.001. From a(n) intercross of QTL Associated with Liver tumor resistance. On Chromosome 1 with a LOD score= , p-value =0.05. From a(n) of
Authors:
Liu H, Higashi K, Hiai H
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