List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Glaucoma (exfoliation). The EFO term exfoliation syndrome was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
G Thorleifsson, KP Magnusson, P Sulem, GB Walters, DF Gudbjartsson, H Stefansson, T Jonsson, A Jonasdottir, A Jonasdottir, G Stefansdottir, G Masson, GA Hardarson, H Petursson, A Arnarsson, M Motallebipour, O Wallerman, C Wadelius, JR Gulcher, U Thorsteinsdottir, A Kong, F Jonasson, K Stefansson
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Exfoliation glaucoma or exfoliation syndrome. The EFO term exfoliation syndrome was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
M Nakano, Y Ikeda, Y Tokuda, M Fuwa, M Ueno, K Imai, R Sato, N Omi, H Adachi, M Kageyama, K Mori, S Kinoshita, K Tashiro
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Exfoliation syndrome. The EFO term exfoliation syndrome was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
T Aung, M Ozaki, T Mizoguchi, RR Allingham, Z Li, A Haripriya, S Nakano, S Uebe, JM Harder, AS Chan, MC Lee, KP Burdon, YS Astakhov, KK Abu-Amero, JC Zenteno, Y Nilgün, T Zarnowski, M Pakravan, LA Safieh, L Jia, YX Wang, S Williams, D Paoli, PG Schlottmann, L Huang, KS Sim, JN Foo, M Nakano, Y Ikeda, RS Kumar, M Ueno, S Manabe, K Hayashi, S Kazama, R Ideta, Y Mori, K Miyata, K Sugiyama, T Higashide, E Chihara, K Inoue, S Ishiko, A Yoshida, M Yanagi, Y Kiuchi, M Aihara, T Ohashi, T Sakurai, T Sugimoto, H Chuman, F Matsuda, K Yamashiro, N Gotoh, M Miyake, SY Astakhov, EA Osman, SA Al-Obeidan, O Owaidhah, L Al-Jasim, S Al Shahwan, RA Fogarty, P Leo, Y Yetkin, Ç Oğuz, MR Kanavi, AN Beni, S Yazdani, EL Akopov, KY Toh, GR Howell, AC Orr, Y Goh, WY Meah, SQ Peh, E Kosior-Jarecka, U Lukasik, M Krumbiegel, EN Vithana, TY Wong, Y Liu, AE Koch, P Challa, RM Rautenbach, DA Mackey, AW Hewitt, P Mitchell, JJ Wang, A Ziskind, T Carmichael, R Ramakrishnan, K Narendran, R Venkatesh, S Vijayan, P Zhao, X Chen, D Guadarrama-Vallejo, CY Cheng, SA Perera, R Husain, SL Ho, UC Welge-Luessen, C Mardin, U Schloetzer-Schrehardt, AM Hillmer, S Herms, S Moebus, MM Nöthen, N Weisschuh, R Shetty, A Ghosh, YY Teo, MA Brown, I Lischinsky, JG Crowston, M Coote, B Zhao, J Sang, N Zhang, Q You, V Vysochinskaya, P Founti, A Chatzikyriakidou, A Lambropoulos, E Anastasopoulos, AL Coleman, MR Wilson, DJ Rhee, JH Kang, I May-Bolchakova, S Heegaard, K Mori, WL Alward, JB Jonas, L Xu, JM Liebmann, B Chowbay, E Schaeffeler, M Schwab, F Lerner, N Wang, Z Yang, P Frezzotti, S Kinoshita, JH Fingert, M Inatani, K Tashiro, A Reis, DP Edward, LR Pasquale, T Kubota, JL Wiggs, F Pasutto, F Topouzis, M Dubina, JE Craig, N Yoshimura, P Sundaresan, SW John, R Ritch, MA Hauser, CC Khor
Genes associated with Homo sapiens that interact with the MeSH term 'entinostat' (C118739). Incorporates data from 11 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Valproic Acid' (D014635). Incorporates data from 1238 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
The processes, properties and biological objects that are involved in maintaining, expressing, and transmitting from one organism to another, genetically encoded traits.
Generated by gene2mesh v. 1.1.1
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Generated by gene2mesh v. 1.1.1
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
Differential gene expression between CS14 and CS17 - Log2FC
Description:
Human craniofacial tissues were collected from the Joint MRC/Wellcome Trust Human Developmental Biology (HDBR). Donations of tissue to HDBR are made under-informed ethical consent with Research Tissue Bank ethical approval by women undergoing termination of pregnancy. Gene expression profiles were generated from multiple biological replicates of primary craniofacial (CF) tissue from Carnegie Stages (CS) of the embryonic period, CS13, CS14, CS17, CS17, and CS22. Here the differential expression comparison between CS14 and CS17 is shown. Gene expressions values with log to the base 2, FC are presented with P-Adj <0.05. UBERON:0015789, cranial or facial muscle.
Authors:
Tara N Yankee, Sungryong Oh, Emma Wentworth Winchester, Andrea Wilderman, Kelsey Robinson, Tia Gordon, Jill A Rosenfeld, Jennifer VanOudenhove, Daryl A Scott, Elizabeth J Leslie, Justin Cotney
Differential gene expression between CS14 and CS17 - Adj-P value
Description:
Human craniofacial tissues were collected from the Joint MRC/Wellcome Trust Human Developmental Biology (HDBR). Donations of tissue to HDBR are made under-informed ethical consent with Research Tissue Bank ethical approval by women undergoing termination of pregnancy. Gene expression profiles were generated from multiple biological replicates of primary craniofacial (CF) tissue from Carnegie Stages (CS) of the embryonic period, CS13, CS14, CS15, CS17 and CS22. Here the differential expression comparison between CS14 and CS17 is shown. Gene expressions values, Ensembl Gene ids and the corresponding Adjusted P value are presented. UBERON:0015789, cranial or facial muscle.
Authors:
Tara N Yankee, Sungryong Oh, Emma Wentworth Winchester, Andrea Wilderman, Kelsey Robinson, Tia Gordon, Jill A Rosenfeld, Jennifer VanOudenhove, Daryl A Scott, Elizabeth J Leslie, Justin Cotney
Differential gene expression between CS15 and CS17 - Adj-P value
Description:
Human craniofacial tissues were collected from the Joint MRC/Wellcome Trust Human Developmental Biology (HDBR). Donations of tissue to HDBR are made under-informed ethical consent with Research Tissue Bank ethical approval by women undergoing termination of pregnancy. Gene expression profiles were generated from multiple biological replicates of primary craniofacial (CF) tissue from Carnegie Stages (CS) of the embryonic period, CS13, CS14, CS17,CS17 and CS22. Here the differential expression comparison between CS15 and CS17 is shown. Gene expressions values, Ensembl Gene ids and the corresponding Adjusted P value are presented. UBERON:0015789, cranial or facial muscle.
Authors:
Tara N Yankee, Sungryong Oh, Emma Wentworth Winchester, Andrea Wilderman, Kelsey Robinson, Tia Gordon, Jill A Rosenfeld, Jennifer VanOudenhove, Daryl A Scott, Elizabeth J Leslie, Justin Cotney
Differential gene expression between CS14 and CS22 - Adj-P value
Description:
Human craniofacial tissues were collected from the Joint MRC/Wellcome Trust Human Developmental Biology (HDBR). Donations of tissue to HDBR are made under-informed ethical consent with Research Tissue Bank ethical approval by women undergoing termination of pregnancy. Gene expression profiles were generated from multiple biological replicates of primary craniofacial (CF) tissue from Carnegie Stages (CS) of the embryonic period, CS13, CS14, CS17, CS17 and CS22. Here the differential expression comparison between CS14 and CS22 is shown. Gene expressions values, Ensembl Gene ids and the corresponding Adjusted P value are presented. UBERON:0015789, cranial or facial muscle.
Authors:
Tara N Yankee, Sungryong Oh, Emma Wentworth Winchester, Andrea Wilderman, Kelsey Robinson, Tia Gordon, Jill A Rosenfeld, Jennifer VanOudenhove, Daryl A Scott, Elizabeth J Leslie, Justin Cotney
Cerebellum Gene Expression Correlates for VONFREYTHRESHOLDMEAN measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The VONFREYTHRESHOLDMEAN measures Mechanical Sensitivity-Von Frey Threshold under the domain Pain. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for OF_CORNER_TIME_PCT measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The OF_CORNER_TIME_PCT measures Open Field - Total time in corners under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for OF_CORNER_TIME_PCT measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The OF_CORNER_TIME_PCT measures Open Field - Total time in corners under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Striatum Gene Expression Correlates for ACTITOT_DIFF measured in BXD RI Females obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ACTITOT_DIFF measures Difference in total distance traveled (cm) (saline-ethanol) under the domain Ethanol. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
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