Cell surface receptors formed from the dimerization of LIF RECEPTOR ALPHA SUBUNIT with CYTOKINE RECEPTOR GP130. Although originally described as receptors for LEUKEMIA INHIBITORY FACTOR these receptors also bind the closely-related protein ONCOSTATIN M and are referred to as both LIF receptors and type I oncostatin M receptors.
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QTL associated with experimental allergic encephalomyelitis susceptibility 6a. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (18146473)
Authors:
Teuscher C, Butterfield RJ, Ma RZ, Zachary JF, Doerge RW, Blankenhorn EP
An INTERLEUKIN-6 related cytokine that exhibits pleiotrophic effects on many physiological systems that involve cell proliferation, differentiation, and survival. Leukemia inhibitory factor binds to and acts through the lif receptor.
Generated by gene2mesh v. 1.1.1
Supplementary Table 2. Overall results of WGCNA combined with differential expression between people with a history of alcohol use and controls BLA: basolateral amygdala
Authors:
Ponomarev I, Wang S, Zhang L, Harris RA, Mayfield RD
534 differentially expressed genes in the prefrontal cortex of adult male C57BL/6J mice within 7 d of withdrawal from chronic cocaine. Gene expression was evaluated using RNA-seq, and validation of DEGs was performed using RT-qPCR. Data taken from Supplemental Table S4. Values presented are log2 fold change. Data can be accessed from GEO with accession # GSE89572.
Authors:
Mingzhen Li, Peng Xu, Yanhua Xu, Huajing Teng, Weiping Tian, Quansheng Du, Mei Zhao
The total transcriptome including genes that are differentially expressed in cocaine addicts compared to control subjects. Post-mortem brain samples were collected from the dorsolateral prefrontal cortex (dlPFC) of the cocaine addict group and the control group. To assess gene expression, RNA-seq was performed. Data taken from Supplementary Table 2. Values presented are k.diff values. Data available from GEO with accession number GSE99349."
Authors:
Efrain A Ribeiro, Joseph R Scarpa, Susanna P Garamszegi, Andrew Kasarskis, Deborah C Mash, Eric J Nestler
Genes that are differentially expressed in adult male C57BL/6J mice given acute cocaine vs. acute saline. Tissue was collected from the ventral tegmental area (VTA) of the brain. Gene expression was evaluated via RNA-seq, and differential gene expression was determined via linear regression (LR).D13 Values presented are p-values. Data taken from Supplementary Table 1. Data available from GEO with accession number GSE155313."
Authors:
Rianne R Campbell, Siwei Chen, Joy H Beardwood, Alberto J López, Lilyana V Pham, Ashley M Keiser, Jessica E Childs, Dina P Matheos, Vivek Swarup, Pierre Baldi, Marcelo A Wood
Genes that are differentially expressed in adult male C57BL/6J mice given chronic cocaine vs. chronic saline. Tissue was collected from the ventral tegmental area (VTA) of the brain. Gene expression was evaluated via RNA-seq, and differential gene expression was determined via linear regression (LR).D13 Values presented are p-values. Data taken from Supplementary Table 1. Data available from GEO with accession number GSE155313."
Authors:
Rianne R Campbell, Siwei Chen, Joy H Beardwood, Alberto J López, Lilyana V Pham, Ashley M Keiser, Jessica E Childs, Dina P Matheos, Vivek Swarup, Pierre Baldi, Marcelo A Wood
Up in human epithelial airway cells after MERS-CoV infection
Description:
These genes were taken from table S2 and represent genes that are upregulated in human epithelial airway cells after MERS-CoV infection and are also differentially regulated in bronchial epithelial cells after SARS-CoV2 infection. Gene symbols were converted to HGNC identifiers. These genes represent those differentially expressed with an adjusted p-value of p<0.01. Values given are log fold change.
RNA-Seq was performed to discover gene expression
changes in the hippocampus of rats in withdrawal from
chronic alcohol exposure. RNA-Seq was performed on the
hippocampus from control, ethanol (no withdrawal), and
ethanol plus withdrawal (24 h) groups. The largest number
of differentially expressed (DE) genes were in the
control vs. withdrawal comparison (925 out of 18,118
detected; q < 0.1)
Authors:
Wei-Yang Chen, Hu Chen, Kana Hamada, Eleonora Gatta, Ying Chen, Huaibo Zhang, Jenny Drnevich, Harish R Krishnan, Mark Maienschein-Cline, Dennis R Grayson, Subhash C Pandey, Amy W Lasek
This gene set comprises 399 genes that are differentially expressed within each of five brain regions (amygdale, hippocampus, nucleus accumbens, prefrontal cortex and ventral tegmental area) when chronic nicotine treatment is administered to C3H/HeJ mice only. Background: Studies involving use of chronic nicotine treatment identify unique nicotine addiction genes and the biological processes they control in B6 and C3 mice. Results are obtained using gene expression profiling and gene ontology.
Authors:
Wang J, Gutala R, Hwang YY, Kim JM, Konu O, Ma JZ, Li MD
This gene set comprises 239 genes that are differentially expressed within each of five brain regions (amygdala, hippocampus, nucleus accumbens, prefrontal cortex and ventral tegmental area) when chronic nicotine treatment is administered to C57BL/6J mice only. Background: Studies involving use of chronic nicotine treatment identify unique nicotine addiction genes and the biological processes they control in B6 and C3 mice. Results are obtained using gene expression profiling and gene ontology.
Authors:
Wang J, Gutala R, Hwang YY, Kim JM, Konu O, Ma JZ, Li MD
Whole Brain Gene Expression Correlates for NEPCOUNT30 measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The NEPCOUNT30 measures Novel environment locomotion (activity beam breaks) 15-30 min in the periphery under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for NEPCOUNT30 measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The NEPCOUNT30 measures Novel environment locomotion (activity beam breaks) 15-30 min in the periphery under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Whole Brain Gene Expression Correlates for NEPCOUNT30 measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The NEPCOUNT30 measures Novel environment locomotion (activity beam breaks) 15-30 min in the periphery under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Whole Brain Gene Expression Correlates for NEPDIST30 measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The NEPDIST30 measures Novel environment distance (cm) travelled min 15-30 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for NEPDIST30 measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The NEPDIST30 measures Novel environment distance (cm) travelled min 15-30 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Whole Brain Gene Expression Correlates for NEPDIST30 measured in BXD RI Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The NEPDIST30 measures Novel environment distance (cm) travelled min 15-30 under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Striatum Gene Expression Correlates for ST_MAX_85 measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ST_MAX_85 measures Maximum startle response to 85 db under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for VOCA_THRESHOLD measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The VOCA_THRESHOLD measures Vocalization Threshold - shock intensity (mA) under the domain Stress Vocalization. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
To further extend these studies to a large number of genes, mRNA profiles from IL-17A- and IL-17F-stimulated cells were studied using microarrays. The expression of several cell-specific markers was analyzed to characterize the population used in the experiment. Microarray-based comparison of IL-17A- and IL-17F-induced effects alone or in combination with TNF-. RA synoviocytes were stimulated with IL-17A or IL-17F (50 ng/ml) alone or in combination with TNF- (0.5 ng/ml) for 12 h. Gene products that showed a signal intensity of 30 or greater were considered as ex- pressed and genes with a 2-fold or greater change were considered as regulated.
Authors:
Zrioual S, Ecochard R, Tournadre A, Lenief V, Cazalis MA, Miossec P
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