Pathway Commons (PC) Geneset. This geneset contains genes that participate in the "IGF1 pathway" pathway. This set was automatically constructed using the PC API.
The original source of this geneset is pid.
gene2pc v. 0.1.0
Last updated 2015.08.31
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Height. The EFO term body height was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
Y Okada, Y Kamatani, A Takahashi, K Matsuda, N Hosono, H Ohmiya, Y Daigo, K Yamamoto, M Kubo, Y Nakamura, N Kamatani
GNF2_IGF1
Neighborhood of IGF1
c4 - Computational genesets defined by mining large collections of cancer-oriented microarray data.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Height. The EFO term body height was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JJ Kim, HI Lee, T Park, K Kim, JE Lee, NH Cho, C Shin, YS Cho, JY Lee, BG Han, HW Yoo, JK Lee
GWAS: dense area measurement, mammographic density measurement
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Mammographic density (dense area). The EFO term dense area measurement, mammographic density measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
S Lindström, DJ Thompson, AD Paterson, J Li, GL Gierach, C Scott, J Stone, JA Douglas, I dos-Santos-Silva, P Fernandez-Navarro, J Verghase, P Smith, J Brown, R Luben, NJ Wareham, RJ Loos, JA Heit, VS Pankratz, A Norman, EL Goode, JM Cunningham, M deAndrade, RA Vierkant, K Czene, PA Fasching, L Baglietto, MC Southey, GG Giles, KP Shah, HP Chan, MA Helvie, AH Beck, NW Knoblauch, A Hazra, DJ Hunter, P Kraft, M Pollan, JD Figueroa, FJ Couch, JL Hopper, P Hall, DF Easton, NF Boyd, CM Vachon, RM Tamimi
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fasting glucose-related traits. The EFO term HOMA-IR was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Dupuis, C Langenberg, I Prokopenko, R Saxena, N Soranzo, AU Jackson, E Wheeler, NL Glazer, N Bouatia-Naji, AL Gloyn, CM Lindgren, R Mägi, AP Morris, J Randall, T Johnson, P Elliott, D Rybin, G Thorleifsson, V Steinthorsdottir, P Henneman, H Grallert, A Dehghan, JJ Hottenga, CS Franklin, P Navarro, K Song, A Goel, JR Perry, JM Egan, T Lajunen, N Grarup, T Sparsø, A Doney, BF Voight, HM Stringham, M Li, S Kanoni, P Shrader, C Cavalcanti-Proença, M Kumari, L Qi, NJ Timpson, C Gieger, C Zabena, G Rocheleau, E Ingelsson, P An, J O'Connell, J Luan, A Elliott, SA McCarroll, F Payne, RM Roccasecca, F Pattou, P Sethupathy, K Ardlie, Y Ariyurek, B Balkau, P Barter, JP Beilby, Y Ben-Shlomo, R Benediktsson, AJ Bennett, S Bergmann, M Bochud, E Boerwinkle, A Bonnefond, LL Bonnycastle, K Borch-Johnsen, Y Böttcher, E Brunner, SJ Bumpstead, G Charpentier, YD Chen, P Chines, R Clarke, LJ Coin, MN Cooper, M Cornelis, G Crawford, L Crisponi, IN Day, EJ de Geus, J Delplanque, C Dina, MR Erdos, AC Fedson, A Fischer-Rosinsky, NG Forouhi, CS Fox, R Frants, MG Franzosi, P Galan, MO Goodarzi, J Graessler, CJ Groves, S Grundy, R Gwilliam, U Gyllensten, S Hadjadj, G Hallmans, N Hammond, X Han, AL Hartikainen, N Hassanali, C Hayward, SC Heath, S Hercberg, C Herder, AA Hicks, DR Hillman, AD Hingorani, A Hofman, J Hui, J Hung, B Isomaa, PR Johnson, T Jørgensen, A Jula, M Kaakinen, J Kaprio, YA Kesaniemi, M Kivimaki, B Knight, S Koskinen, P Kovacs, KO Kyvik, GM Lathrop, DA Lawlor, O Le Bacquer, C Lecoeur, Y Li, V Lyssenko, R Mahley, M Mangino, AK Manning, MT MartÃnez-Larrad, JB McAteer, LJ McCulloch, R McPherson, C Meisinger, D Melzer, D Meyre, BD Mitchell, MA Morken, S Mukherjee, S Naitza, N Narisu, MJ Neville, BA Oostra, M Orrù, R Pakyz, CN Palmer, G Paolisso, C Pattaro, D Pearson, JF Peden, NL Pedersen, M Perola, AF Pfeiffer, I Pichler, O Polasek, D Posthuma, SC Potter, A Pouta, MA Province, BM Psaty, W Rathmann, NW Rayner, K Rice, S Ripatti, F Rivadeneira, M Roden, O Rolandsson, A Sandbaek, M Sandhu, S Sanna, AA Sayer, P Scheet, LJ Scott, U Seedorf, SJ Sharp, B Shields, G Sigurethsson, EJ Sijbrands, A Silveira, L Simpson, A Singleton, NL Smith, U Sovio, A Swift, H Syddall, AC Syvänen, T Tanaka, B Thorand, J Tichet, A Tönjes, T Tuomi, AG Uitterlinden, KW van Dijk, M van Hoek, D Varma, S Visvikis-Siest, V Vitart, N Vogelzangs, G Waeber, PJ Wagner, A Walley, GB Walters, KL Ward, H Watkins, MN Weedon, SH Wild, G Willemsen, JC Witteman, JW Yarnell, E Zeggini, D Zelenika, B Zethelius, G Zhai, JH Zhao, MC Zillikens, IB Borecki, RJ Loos, P Meneton, PK Magnusson, DM Nathan, GH Williams, AT Hattersley, K Silander, V Salomaa, GD Smith, SR Bornstein, P Schwarz, J Spranger, F Karpe, AR Shuldiner, C Cooper, GV Dedoussis, M Serrano-RÃos, AD Morris, L Lind, LJ Palmer, FB Hu, PW Franks, S Ebrahim, M Marmot, WH Kao, JS Pankow, MJ Sampson, J Kuusisto, M Laakso, T Hansen, O Pedersen, PP Pramstaller, HE Wichmann, T Illig, I Rudan, AF Wright, M Stumvoll, H Campbell, JF Wilson, RN Bergman, TA Buchanan, FS Collins, KL Mohlke, J Tuomilehto, TT Valle, D Altshuler, JI Rotter, DS Siscovick, BW Penninx, DI Boomsma, P Deloukas, TD Spector, TM Frayling, L Ferrucci, A Kong, U Thorsteinsdottir, K Stefansson, CM van Duijn, YS Aulchenko, A Cao, A Scuteri, D Schlessinger, M Uda, A Ruokonen, MR Jarvelin, DM Waterworth, P Vollenweider, L Peltonen, V Mooser, GR Abecasis, NJ Wareham, R Sladek, P Froguel, RM Watanabe, JB Meigs, L Groop, M Boehnke, MI McCarthy, JC Florez, I Barroso
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fasting glucose-related traits. The EFO term fasting blood insulin measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Dupuis, C Langenberg, I Prokopenko, R Saxena, N Soranzo, AU Jackson, E Wheeler, NL Glazer, N Bouatia-Naji, AL Gloyn, CM Lindgren, R Mägi, AP Morris, J Randall, T Johnson, P Elliott, D Rybin, G Thorleifsson, V Steinthorsdottir, P Henneman, H Grallert, A Dehghan, JJ Hottenga, CS Franklin, P Navarro, K Song, A Goel, JR Perry, JM Egan, T Lajunen, N Grarup, T Sparsø, A Doney, BF Voight, HM Stringham, M Li, S Kanoni, P Shrader, C Cavalcanti-Proença, M Kumari, L Qi, NJ Timpson, C Gieger, C Zabena, G Rocheleau, E Ingelsson, P An, J O'Connell, J Luan, A Elliott, SA McCarroll, F Payne, RM Roccasecca, F Pattou, P Sethupathy, K Ardlie, Y Ariyurek, B Balkau, P Barter, JP Beilby, Y Ben-Shlomo, R Benediktsson, AJ Bennett, S Bergmann, M Bochud, E Boerwinkle, A Bonnefond, LL Bonnycastle, K Borch-Johnsen, Y Böttcher, E Brunner, SJ Bumpstead, G Charpentier, YD Chen, P Chines, R Clarke, LJ Coin, MN Cooper, M Cornelis, G Crawford, L Crisponi, IN Day, EJ de Geus, J Delplanque, C Dina, MR Erdos, AC Fedson, A Fischer-Rosinsky, NG Forouhi, CS Fox, R Frants, MG Franzosi, P Galan, MO Goodarzi, J Graessler, CJ Groves, S Grundy, R Gwilliam, U Gyllensten, S Hadjadj, G Hallmans, N Hammond, X Han, AL Hartikainen, N Hassanali, C Hayward, SC Heath, S Hercberg, C Herder, AA Hicks, DR Hillman, AD Hingorani, A Hofman, J Hui, J Hung, B Isomaa, PR Johnson, T Jørgensen, A Jula, M Kaakinen, J Kaprio, YA Kesaniemi, M Kivimaki, B Knight, S Koskinen, P Kovacs, KO Kyvik, GM Lathrop, DA Lawlor, O Le Bacquer, C Lecoeur, Y Li, V Lyssenko, R Mahley, M Mangino, AK Manning, MT MartÃnez-Larrad, JB McAteer, LJ McCulloch, R McPherson, C Meisinger, D Melzer, D Meyre, BD Mitchell, MA Morken, S Mukherjee, S Naitza, N Narisu, MJ Neville, BA Oostra, M Orrù, R Pakyz, CN Palmer, G Paolisso, C Pattaro, D Pearson, JF Peden, NL Pedersen, M Perola, AF Pfeiffer, I Pichler, O Polasek, D Posthuma, SC Potter, A Pouta, MA Province, BM Psaty, W Rathmann, NW Rayner, K Rice, S Ripatti, F Rivadeneira, M Roden, O Rolandsson, A Sandbaek, M Sandhu, S Sanna, AA Sayer, P Scheet, LJ Scott, U Seedorf, SJ Sharp, B Shields, G Sigurethsson, EJ Sijbrands, A Silveira, L Simpson, A Singleton, NL Smith, U Sovio, A Swift, H Syddall, AC Syvänen, T Tanaka, B Thorand, J Tichet, A Tönjes, T Tuomi, AG Uitterlinden, KW van Dijk, M van Hoek, D Varma, S Visvikis-Siest, V Vitart, N Vogelzangs, G Waeber, PJ Wagner, A Walley, GB Walters, KL Ward, H Watkins, MN Weedon, SH Wild, G Willemsen, JC Witteman, JW Yarnell, E Zeggini, D Zelenika, B Zethelius, G Zhai, JH Zhao, MC Zillikens, IB Borecki, RJ Loos, P Meneton, PK Magnusson, DM Nathan, GH Williams, AT Hattersley, K Silander, V Salomaa, GD Smith, SR Bornstein, P Schwarz, J Spranger, F Karpe, AR Shuldiner, C Cooper, GV Dedoussis, M Serrano-RÃos, AD Morris, L Lind, LJ Palmer, FB Hu, PW Franks, S Ebrahim, M Marmot, WH Kao, JS Pankow, MJ Sampson, J Kuusisto, M Laakso, T Hansen, O Pedersen, PP Pramstaller, HE Wichmann, T Illig, I Rudan, AF Wright, M Stumvoll, H Campbell, JF Wilson, RN Bergman, TA Buchanan, FS Collins, KL Mohlke, J Tuomilehto, TT Valle, D Altshuler, JI Rotter, DS Siscovick, BW Penninx, DI Boomsma, P Deloukas, TD Spector, TM Frayling, L Ferrucci, A Kong, U Thorsteinsdottir, K Stefansson, CM van Duijn, YS Aulchenko, A Cao, A Scuteri, D Schlessinger, M Uda, A Ruokonen, MR Jarvelin, DM Waterworth, P Vollenweider, L Peltonen, V Mooser, GR Abecasis, NJ Wareham, R Sladek, P Froguel, RM Watanabe, JB Meigs, L Groop, M Boehnke, MI McCarthy, JC Florez, I Barroso
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Fasting insulin-related traits. The EFO term HOMA-IR, fasting blood insulin measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Dupuis, C Langenberg, I Prokopenko, R Saxena, N Soranzo, AU Jackson, E Wheeler, NL Glazer, N Bouatia-Naji, AL Gloyn, CM Lindgren, R Mägi, AP Morris, J Randall, T Johnson, P Elliott, D Rybin, G Thorleifsson, V Steinthorsdottir, P Henneman, H Grallert, A Dehghan, JJ Hottenga, CS Franklin, P Navarro, K Song, A Goel, JR Perry, JM Egan, T Lajunen, N Grarup, T Sparsø, A Doney, BF Voight, HM Stringham, M Li, S Kanoni, P Shrader, C Cavalcanti-Proença, M Kumari, L Qi, NJ Timpson, C Gieger, C Zabena, G Rocheleau, E Ingelsson, P An, J O'Connell, J Luan, A Elliott, SA McCarroll, F Payne, RM Roccasecca, F Pattou, P Sethupathy, K Ardlie, Y Ariyurek, B Balkau, P Barter, JP Beilby, Y Ben-Shlomo, R Benediktsson, AJ Bennett, S Bergmann, M Bochud, E Boerwinkle, A Bonnefond, LL Bonnycastle, K Borch-Johnsen, Y Böttcher, E Brunner, SJ Bumpstead, G Charpentier, YD Chen, P Chines, R Clarke, LJ Coin, MN Cooper, M Cornelis, G Crawford, L Crisponi, IN Day, EJ de Geus, J Delplanque, C Dina, MR Erdos, AC Fedson, A Fischer-Rosinsky, NG Forouhi, CS Fox, R Frants, MG Franzosi, P Galan, MO Goodarzi, J Graessler, CJ Groves, S Grundy, R Gwilliam, U Gyllensten, S Hadjadj, G Hallmans, N Hammond, X Han, AL Hartikainen, N Hassanali, C Hayward, SC Heath, S Hercberg, C Herder, AA Hicks, DR Hillman, AD Hingorani, A Hofman, J Hui, J Hung, B Isomaa, PR Johnson, T Jørgensen, A Jula, M Kaakinen, J Kaprio, YA Kesaniemi, M Kivimaki, B Knight, S Koskinen, P Kovacs, KO Kyvik, GM Lathrop, DA Lawlor, O Le Bacquer, C Lecoeur, Y Li, V Lyssenko, R Mahley, M Mangino, AK Manning, MT MartÃnez-Larrad, JB McAteer, LJ McCulloch, R McPherson, C Meisinger, D Melzer, D Meyre, BD Mitchell, MA Morken, S Mukherjee, S Naitza, N Narisu, MJ Neville, BA Oostra, M Orrù, R Pakyz, CN Palmer, G Paolisso, C Pattaro, D Pearson, JF Peden, NL Pedersen, M Perola, AF Pfeiffer, I Pichler, O Polasek, D Posthuma, SC Potter, A Pouta, MA Province, BM Psaty, W Rathmann, NW Rayner, K Rice, S Ripatti, F Rivadeneira, M Roden, O Rolandsson, A Sandbaek, M Sandhu, S Sanna, AA Sayer, P Scheet, LJ Scott, U Seedorf, SJ Sharp, B Shields, G Sigurethsson, EJ Sijbrands, A Silveira, L Simpson, A Singleton, NL Smith, U Sovio, A Swift, H Syddall, AC Syvänen, T Tanaka, B Thorand, J Tichet, A Tönjes, T Tuomi, AG Uitterlinden, KW van Dijk, M van Hoek, D Varma, S Visvikis-Siest, V Vitart, N Vogelzangs, G Waeber, PJ Wagner, A Walley, GB Walters, KL Ward, H Watkins, MN Weedon, SH Wild, G Willemsen, JC Witteman, JW Yarnell, E Zeggini, D Zelenika, B Zethelius, G Zhai, JH Zhao, MC Zillikens, IB Borecki, RJ Loos, P Meneton, PK Magnusson, DM Nathan, GH Williams, AT Hattersley, K Silander, V Salomaa, GD Smith, SR Bornstein, P Schwarz, J Spranger, F Karpe, AR Shuldiner, C Cooper, GV Dedoussis, M Serrano-RÃos, AD Morris, L Lind, LJ Palmer, FB Hu, PW Franks, S Ebrahim, M Marmot, WH Kao, JS Pankow, MJ Sampson, J Kuusisto, M Laakso, T Hansen, O Pedersen, PP Pramstaller, HE Wichmann, T Illig, I Rudan, AF Wright, M Stumvoll, H Campbell, JF Wilson, RN Bergman, TA Buchanan, FS Collins, KL Mohlke, J Tuomilehto, TT Valle, D Altshuler, JI Rotter, DS Siscovick, BW Penninx, DI Boomsma, P Deloukas, TD Spector, TM Frayling, L Ferrucci, A Kong, U Thorsteinsdottir, K Stefansson, CM van Duijn, YS Aulchenko, A Cao, A Scuteri, D Schlessinger, M Uda, A Ruokonen, MR Jarvelin, DM Waterworth, P Vollenweider, L Peltonen, V Mooser, GR Abecasis, NJ Wareham, R Sladek, P Froguel, RM Watanabe, JB Meigs, L Groop, M Boehnke, MI McCarthy, JC Florez, I Barroso
Human Phenotype Ontology (HPO) gene set. This set contains genes that have been annotated to the HPO term "Decreased serum insulin-like growth factor 1", which is defined as "A reduced level of insulin-like growth factor 1 (IGF1) in the blood circulation." This gene set was automatically constructed using annotation and ontology data provided by HPO and includes gene-phenotypes annotations from all HPO sources. The transitive closure of this term is taken into account using is_a relationships. For more information: The Human Phenotype Ontology Consortium (HPOC), http://human-phenotype-ontology.org This gene set was generated using the GeneWeaver HPO loader v. 0.1.5, HPO OBO v. hp/releases/2020-03-27, and HPO Genes to Phenotypes (all sources, all frequencies) v. 2020.05.06.
Authors:
S Köhler, SC Doelken, CJ Mungall, S Bauer, HV Firth, I Bailleul-Forestier, GC Black, DL Brown, M Brudno, J Campbell, DR FitzPatrick, JT Eppig, AP Jackson, K Freson, M Girdea, I Helbig, JA Hurst, J Jähn, LG Jackson, AM Kelly, DH Ledbetter, S Mansour, CL Martin, C Moss, A Mumford, WH Ouwehand, SM Park, ER Riggs, RH Scott, S Sisodiya, S Van Vooren, RJ Wapner, AO Wilkie, CF Wright, AT Vulto-van Silfhout, N de Leeuw, BB de Vries, NL Washingthon, CL Smith, M Westerfield, P Schofield, BJ Ruef, GV Gkoutos, M Haendel, D Smedley, SE Lewis, PN Robinson
Human Phenotype Ontology (HPO) gene set. This set contains genes that have been annotated to the HPO term "Abnormal serum insulin-like growth factor 1 level", which is defined as "An anomalous level of insulin-like growth factor 1 (IGF1) in the blood circulation." This gene set was automatically constructed using annotation and ontology data provided by HPO and includes gene-phenotypes annotations from all HPO sources. The transitive closure of this term is taken into account using is_a relationships. For more information: The Human Phenotype Ontology Consortium (HPOC), http://human-phenotype-ontology.org This gene set was generated using the GeneWeaver HPO loader v. 0.1.5, HPO OBO v. hp/releases/2020-03-27, and HPO Genes to Phenotypes (all sources, all frequencies) v. 2020.05.06.
Authors:
S Köhler, SC Doelken, CJ Mungall, S Bauer, HV Firth, I Bailleul-Forestier, GC Black, DL Brown, M Brudno, J Campbell, DR FitzPatrick, JT Eppig, AP Jackson, K Freson, M Girdea, I Helbig, JA Hurst, J Jähn, LG Jackson, AM Kelly, DH Ledbetter, S Mansour, CL Martin, C Moss, A Mumford, WH Ouwehand, SM Park, ER Riggs, RH Scott, S Sisodiya, S Van Vooren, RJ Wapner, AO Wilkie, CF Wright, AT Vulto-van Silfhout, N de Leeuw, BB de Vries, NL Washingthon, CL Smith, M Westerfield, P Schofield, BJ Ruef, GV Gkoutos, M Haendel, D Smedley, SE Lewis, PN Robinson
Human Phenotype Ontology (HPO) gene set. This set contains genes that have been annotated to the HPO term "Increased serum insulin-like growth factor 1", which is defined as "An elevated level of insulin-like growth factor 1 (IGF1) in the blood circulation." This gene set was automatically constructed using annotation and ontology data provided by HPO and includes gene-phenotypes annotations from all HPO sources. The transitive closure of this term is taken into account using is_a relationships. For more information: The Human Phenotype Ontology Consortium (HPOC), http://human-phenotype-ontology.org This gene set was generated using the GeneWeaver HPO loader v. 0.1.5, HPO OBO v. hp/releases/2020-03-27, and HPO Genes to Phenotypes (all sources, all frequencies) v. 2020.05.06.
Authors:
S Köhler, SC Doelken, CJ Mungall, S Bauer, HV Firth, I Bailleul-Forestier, GC Black, DL Brown, M Brudno, J Campbell, DR FitzPatrick, JT Eppig, AP Jackson, K Freson, M Girdea, I Helbig, JA Hurst, J Jähn, LG Jackson, AM Kelly, DH Ledbetter, S Mansour, CL Martin, C Moss, A Mumford, WH Ouwehand, SM Park, ER Riggs, RH Scott, S Sisodiya, S Van Vooren, RJ Wapner, AO Wilkie, CF Wright, AT Vulto-van Silfhout, N de Leeuw, BB de Vries, NL Washingthon, CL Smith, M Westerfield, P Schofield, BJ Ruef, GV Gkoutos, M Haendel, D Smedley, SE Lewis, PN Robinson
Human Phenotype Ontology (HPO) gene set. This set contains genes that have been annotated to the HPO term "Abnormal insulin like growth factor binding protein acid labile subunit level", which is defined as "A deviation from the normal blood concentration of the insulin like growth factor binding protein acid labile subunit (IGFALS; Entrez Gene ID 3483). The acid-labile subunit (IGFALS) acts in the insulin-like growth (IGF) system by binding circulating IGF1 in a ternary complex with binding protein (IGFBP)-3 to prevent IGF1 from crossing the endothelial barrier." This gene set was automatically constructed using annotation and ontology data provided by HPO and includes gene-phenotypes annotations from all HPO sources. The transitive closure of this term is taken into account using is_a relationships. For more information: The Human Phenotype Ontology Consortium (HPOC), http://human-phenotype-ontology.org This gene set was generated using the GeneWeaver HPO loader v. 0.1.5, HPO OBO v. hp/releases/2020-03-27, and HPO Genes to Phenotypes (all sources, all frequencies) v. 2020.05.06.
Authors:
S Köhler, SC Doelken, CJ Mungall, S Bauer, HV Firth, I Bailleul-Forestier, GC Black, DL Brown, M Brudno, J Campbell, DR FitzPatrick, JT Eppig, AP Jackson, K Freson, M Girdea, I Helbig, JA Hurst, J Jähn, LG Jackson, AM Kelly, DH Ledbetter, S Mansour, CL Martin, C Moss, A Mumford, WH Ouwehand, SM Park, ER Riggs, RH Scott, S Sisodiya, S Van Vooren, RJ Wapner, AO Wilkie, CF Wright, AT Vulto-van Silfhout, N de Leeuw, BB de Vries, NL Washingthon, CL Smith, M Westerfield, P Schofield, BJ Ruef, GV Gkoutos, M Haendel, D Smedley, SE Lewis, PN Robinson
Striatum Gene Expression Correlates for ACTI_DIFF_20 measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ACTI_DIFF_20 measures Difference in distance traveled (cm) during the first last min (saline-ethanol) under the domain Ethanol. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for VOCA_THRESHOLD measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The VOCA_THRESHOLD measures Vocalization Threshold - shock intensity (mA) under the domain Stress Vocalization. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for VOCA_THRESHOLD measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The VOCA_THRESHOLD measures Vocalization Threshold - shock intensity (mA) under the domain Stress Vocalization. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
QTL for alcohol preference on Chr10 at NA (71.07 Mbp , Build 37)
Description:
alcohol preference spans 46.07 - 96.07 Mbp (NCBI Build 37) on Chr10. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for ethanol withdrawal on Chr10 at Ha1 (98.44 Mbp , Build 37)
Description:
ethanol withdrawal spans 73.44 - 123.44 Mbp (NCBI Build 37) on Chr10. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for METH responses for home cage activity on Chr10 at D10Mit144 (102.84 Mbp , Build 37)
Description:
METH responses for home cage activity spans 77.84 - 127.84 Mbp (NCBI Build 37) on Chr10. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Chronic cocaine - Cocaine-paired (conditioned place preference) vs. Control (saline or cocaine-non-paired) DNA microarray All genes on microarray presented After the pre-conditioning phase where animals were allowed access to either compartment for 15 minutes for 4 consecutive days, the conditioning phase for the cocaine-paired groups and cocaine non-paired groups began, consisting of eight subsequent daily sessions. For both groups, cocaine (10 mg / kg) or saline injections were administered on alternate days. For the cocaine-paired groups, rats were immediately placed in one of the two compartments for 30 min with the door in place restricting a z transformation followed by z test and anova followed by Student-Newman-Keuls' post hoc test. Gene expression profile was assessed 24 h after the last conditioning session that corresponded to 48 h after last cocaine exposure, when drug has been eliminated from the body and transient transcriptional changes are likely to be minimal. Therefore, changes in gene expression at this time-point are likely to reflect longer lasting adaptations that may account for maintenance of cocaine-induced memories. The complete lists of normalized gene expression values for the hippocampus of saline-treated, cocaine non-paired and cocaine-paired groups are presented. Analyses revealed that 214 transcripts were differentially regulated in the hippocampus of cocaine-paired rats vs. non-paired and saline-treated controls. Cocaine-induced conditioned place preference caused significant increases in the expression of 151 genes and caused decreases in the expression of 63 genes. (NIF Table ID 130.1 [83])
Authors:
Krasnova IN, Li SM, Wood WH, McCoy MT, Prabhu VV, Becker KG, Katz JL, Cadet JL
Chronic cocaine - Cocaine-paired (conditioned place preference) vs. Control (saline or cocaine-non-paired) DNA microarray All genes on microarray presented After the pre-conditioning phase where animals were allowed access to either compartment for 15 minutes for 4 consecutive days, the conditioning phase for the cocaine-paired groups and cocaine non-paired groups began, consisting of eight subsequent daily sessions. For both groups, cocaine (10 mg / kg) or saline injections were administered on alternate days. For the cocaine-paired groups, rats were immediately placed in one of the two compartments for 30 min with the door in place restricting a z transformation followed by z test and anova followed by Student-Newman-Keuls' post hoc test. Gene expression profile was assessed 24 h after the last conditioning session that corresponded to 48 h after last cocaine exposure, when drug has been eliminated from the body and transient transcriptional changes are likely to be minimal. Therefore, changes in gene expression at this time-point are likely to reflect longer lasting adaptations that may account for maintenance of cocaine-induced memories. The complete lists of normalized gene expression values for the frontal cortex of saline-treated, cocaine non-paired and cocaine-paired groups are presented. Differences in the expression of 39 transcripts in the frontal cortex were related to the conditioned place preference paradigm. These include increases in the level of 22 genes and decreases in 17 genes. (NIF Table ID 130.3 [83.5])
Authors:
Krasnova IN, Li SM, Wood WH, McCoy MT, Prabhu VV, Becker KG, Katz JL, Cadet JL
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