List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Graves' disease. The EFO term Graves disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
SX Zhao, LQ Xue, W Liu, ZH Gu, CM Pan, SY Yang, M Zhan, HN Wang, J Liang, GQ Gao, XM Zhang, GY Yuan, CG Li, WH Du, BL Liu, LB Liu, G Chen, Q Su, YD Peng, JJ Zhao, G Ning, W Huang, L Liang, L Qi, SJ Chen, Z Chen, JL Chen, HD Song
Striatum Gene Expression Correlates for LM_SUPPRESSION measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The LM_SUPPRESSION measures Cue Conditioning - Activity suppression after 3rd tone/shock pairing under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for LM_SUPPRESSION measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The LM_SUPPRESSION measures Cue Conditioning - Activity suppression after 3rd tone/shock pairing under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Genes associated with Homo sapiens that interact with the MeSH term 'quercitrin' (C012526). Incorporates data from 724 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Methyl Methanesulfonate' (D008741). Incorporates data from 2 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
"greater than normal number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"any anomaly in the number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"any functional anomaly of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"the observable morphological, physiological, behavioral and other characteristics of mammalian organisms that are manifested through development and lifespan" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
decreased susceptibility to experimental autoimmune encephalomyelitis (MP)
Description:
"reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"abnormal development of blood cells in the fetal and adult organism; in the fetus cells develop in the aorta, genital ridge and mesonephros region and later in the liver; in adults cells normally develop in the bone marrow and lymphatic tissues" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"anomaly in the process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
decreased susceptibility to autoimmune disorder (MP)
Description:
"reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"any structural anomaly of a leukocyte with a single non-segmented nucleus in the mature form" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
"increase in the ability of a naive T cell population to undergo rapid expansion by cell division in response to stimuli" Data derived from MGI_GenePheno.rpt and the MP OBO tree dated 2016-11-07
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