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cocaine related behavior spans 61.29 - 111.29 Mbp (NCBI Build 37) on Chr4. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Genes with particular expression in the Interposed nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Dorsal cochlear nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Granular lamina of the cochlear nuclei. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Lateral amygdalar nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Copula pyramidis, granular layer. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Lingula (I), molecular layer. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Cerebellar nuclei. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Agranular insular area, ventral part, layer 2/3. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Fasciola cinerea. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Lingula (I), granular layer. Data represent fold expression difference in structure versus grey matter average expression.
The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
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