QTL for chronic alcohol withdrawal severity on Chr8 at D8Mit25 (65.54 Mbp , Build 37)
Description:
chronic alcohol withdrawal severity spans 40.54 - 90.54 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Bergeson SE, Kyle Warren R, Crabbe JC, Metten P, Gene Erwin V, Belknap JK
QTL for METH responses for body temperature on Chr8 at D8Ncvs43 (95.66 Mbp , Build 37)
Description:
METH responses for body temperature spans 70.66 - 120.66 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "Circadian entrainment" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "Chemokine signaling pathway" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "Pathways in cancer" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "Retrograde endocannabinoid signaling" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "Glutamatergic synapse" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "Cholinergic synapse" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "Serotonergic synapse" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "GABAergic synapse" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "Dopaminergic synapse" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "Regulation of actin cytoskeleton" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "PI3K-Akt signaling pathway" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "MAPK signaling pathway" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "Morphine addiction" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "Alcoholism" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
Kyoto Encyclopedia of Genes and Genomes (KEGG) Geneset. This geneset contains genes that participate in the "Ras signaling pathway" pathway. This set was automatically constructed using the KEGG API and enumerating all mouse pathways.
gene2kegg v. 0.1.1
Last updated 2015.09.10
differentially expressed genes (p < .05) for short access cocaine self-admin (2 weeks) or saline self-admin from C57 inbred mice. Used data from Walker et al. 2018 Biological Psychiatry.
Genes that are induced by THC in total lymph node (LN) cells in C57BL/6J mice. Gene expression was evaluated via RNA-seq. Values presented are "1" for effect presence. Data taken from Supplemental Data 1.
Authors:
Xiaoming Yang, Marpe Bam, Prakash S Nagarkatti, Mitzi Nagarkatti
Genes that are induced by THC in CD4 cells in C57BL/6J mice. Gene expression was evaluated via RNA-seq. Values presented are "1" for effect presence. Data taken from Supplemental Data 1.
Authors:
Xiaoming Yang, Marpe Bam, Prakash S Nagarkatti, Mitzi Nagarkatti
Genes that are induced by THC in both CD4+ cells and total lymph node (LN) cells in C57BL/6J mice. Gene expression was evaluated via RNA-seq. Values presented are "1" for effect presence. Data taken from Supplemental Data 1.
Authors:
Xiaoming Yang, Marpe Bam, Prakash S Nagarkatti, Mitzi Nagarkatti
Alcohol transcriptome changes in mice microglia p-value
Description:
Microglia are fundamentally important immune cells within the central nervous system (CNS) that respond to environmental challenges to maintain normal physiological processes. Alterations in steady-state cellular function and over-activation of microglia can facilitate the initiation and progression of neuropathological conditions such as Alzheimer’s disease, Multiple Sclerosis, and Major Depressive Disorder. Alcohol consumption disrupts signaling pathways including both innate and adaptive immune responses that are necessary for CNS homeostasis. Coordinate expression of these genes is not ascertained from an admixture of CNS cell-types, underscoring the importance of examining isolated cellular populations to reveal systematic gene expression changes arising from mature microglia. Unbiased RNA-Seq profiling was used to identify gene expression changes in isolated prefrontal cortical microglia in response to recurring bouts of voluntary alcohol drinking behavior. The voluntary ethanol paradigm utilizes long-term consumption ethanol that results in escalated alcohol intake and altered cortical plasticity that is seen in humans. Gene coexpression analysis identified a coordinately regulated group of genes, unique to microglia, that collectively are associated with alcohol consumption. Genes within this group are involved in toll-like receptor signaling and transforming growth factor beta signaling. Network connectivity of this group identified Siglech as a putative hub gene and highlighted the potential importance of proteases in the microglial response to chronic ethanol. In conclusion, we identified a distinctive microglial gene expression signature for neuroimmune responses related to alcohol consumption that provides valuable insight into microglia-specific changes underlying the development of substance abuse, and possibly other CNS disorders.
Authors:
Gizelle M McCarthy, Sean P Farris, Yuri A Blednov, R Adron Harris, R Dayne Mayfield
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