QTL for ethanol withdrawal on Chr12 at D12Ncvs38 (14.25 Mbp , Build 37)
Description:
ethanol withdrawal spans 0.00 - 39.25 Mbp (NCBI Build 37) on Chr12. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL for differences in cocaine responsiveness on Chr12 at D12M!t2 (39.51 Mbp , Build 37)
Description:
differences in cocaine responsiveness spans 14.51 - 64.51 Mbp (NCBI Build 37) on Chr12. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Genes with particular expression in the Primary visual area, layer 6a. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Perihypoglossal nuclei. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anterior olfactory nucleus, dorsal part. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Nucleus prepositus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anterior olfactory nucleus, external part. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Accessory olfactory bulb, glomerular layer. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Accessory olfactory bulb, mitral layer. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Primary visual area, layer 6b. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the posteromedial visual area, layer 6b. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Retrosplenial area, ventral part, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Ventral tegmental nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Subiculum, dorsal part, pyramidal layer. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Paragigantocellular reticular nucleus, dorsal part. Data represent fold expression difference in structure versus grey matter average expression.
We investigated the role of microglia in a mouse model of alcohol dependence using a colony stimulating factor 1 receptor inhibitor (PLX5622) to deplete microglia and a chronic intermittent ethanol vapor two-bottle choice drinking procedure. Additionally, we examined anxiety-like behavior during withdrawal. We then analyzed synaptic neuroadaptations in the central nucleus of the amygdala (CeA) and gene expression changes in the medial prefrontal cortex (mPFC) and CeA from the same animals used for behavioral studies.
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