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Molecular mechanisms associated with opioid-induced hyperalgesia (OIH) by comparing mice presenting OIH symptoms in response to chronic morphine exposure (OIH treatment) relative to control mice (CON treatment). Using RNA-Seq profiles, gene networks were inferred in the trigeminal ganglia (TG), a central nervous system region associated with pain signaling, and in the nucleus accumbens (NAc), a region associated with reward dependency. Mice in the OIH treatment group were injected with morphine dissolved in 0.9% saline solution whereas mice in the CON treatment group were injected with saline vehicle administered as a 10mL/kg volume. Extended list of genes differentially expressed (FDR-adjusted P-value < 0.1) between opioid-induced hyperalgesia (OIH) and control (CON) mice.
Authors:
Pan Zhang, Laura S Moye, Bruce R Southey, Isaac Dripps, Jonathan V Sweedler, Amynah Pradhan, Sandra L Rodriguez-Zas