QTL associated with keratinocyte stem cell locus 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (9322672)
QTL associated with salmonella enteritidis susceptibility 8. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25610387)
534 differentially expressed genes in the prefrontal cortex of adult male C57BL/6J mice within 7 d of withdrawal from chronic cocaine. Gene expression was evaluated using RNA-seq, and validation of DEGs was performed using RT-qPCR. Data taken from Supplemental Table S4. Values presented are log2 fold change. Data can be accessed from GEO with accession # GSE89572.
Authors:
Mingzhen Li, Peng Xu, Yanhua Xu, Huajing Teng, Weiping Tian, Quansheng Du, Mei Zhao
Drug Naïve DO mice were tested for open field, light dark, hole board, novelty place preference before collecting the striatum. RNA-Seq data was analyzed with WGCNA using a soft thresholding power of 3 selected using the WGCNA scale-free topology R2 threshold of 0.9, signed network with a minimum module size of 30, correlation type is bicor, used numeric labels.
Drug Naïve DO mice were tested for open field, light dark, hole board, novelty place preference before collecting the striatum. RNA-Seq data was analyzed with paraclique using a bicor was used with a correlation coefficient threshold of |0.5| (unsigned), minimum seed clique size of 5, minimum finished paraclique size of 10, proportional glom factor of 0.2 for paraclique construction.
The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
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