The endogenously depressed rat and its control strain were developed by bidirectional selective breeding from the Wistar–Kyoto (WKY) rat, an accepted model of major depressive disorder (MDD). The WKY More Immobile (WMI) substrain shows high immobility/ despair-like behavior in the forced swim test (FST), while the control substrain, WKY Less Immobile (WLI), shows no depressive behavior in the FST. Chronic stress responses were investigated by using Brown Norway, Fischer 344, Lewis and WKY, genetically and behaviorally distinct strains of rats. Animals were either not stressed (NS) or exposed to chronic restraint stress (CRS). Genome-wide microarray analyses identified differentially expressed genes in hippocampi and amygdalae of the endogenous depression and the chronic stress models. Statistics reported with p-value.
Authors:
Andrus BM, Blizinsky K, Vedell PT, Dennis K, Shukla PK, Schaffer DJ, Radulovic J, Churchill GA, Redei EE
The endogenously depressed rat and its control strain were developed by bidirectional selective breeding from the Wistar–Kyoto (WKY) rat, an accepted model of major depressive disorder (MDD). The WKY More Immobile (WMI) substrain shows high immobility/ despair-like behavior in the forced swim test (FST), while the control substrain, WKY Less Immobile (WLI), shows no depressive behavior in the FST. Chronic stress responses were investigated by using Brown Norway, Fischer 344, Lewis and WKY, genetically and behaviorally distinct strains of rats. Animals were either not stressed (NS) or exposed to chronic restraint stress (CRS). Genome-wide microarray analyses identified differentially expressed genes in hippocampi and amygdalae of the endogenous depression and the chronic stress models. Statistics reported as p-value.
Authors:
Andrus BM, Blizinsky K, Vedell PT, Dennis K, Shukla PK, Schaffer DJ, Radulovic J, Churchill GA, Redei EE
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Acne (severe). The EFO term acne was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
QTL Associated with Activity level. On Chromosome 2 with a LOD score= , p-value =0.0035. From a(n) of QTL Associated with Activity level. On Chromosome 3 with a LOD score= , p-value =0.0028. From a(n) of
Authors:
Solberg LC, Baum AE, Ahmadiyeh N, Shimomura K, Li R, Turek FW, Churchill GA, Takahashi JS, Redei EE
The testing of different hypotheses of the etiology of depression was performed. Both non-stressed and chronic restraint stressed rats were observed to determine the differential expression of genes in populations of Wistar-Kyoto rats. 126 genes within the hippocampus were determined to be differential between the two testing conditions.
Authors:
Andrus BM, Blizinsky K, Vedell PT, Dennis K, Shukla PK, Schaffer DJ, Radulovic J, Churchill GA, Redei EE
The testing of different hypotheses of the etiology of depression was performed. Both non-stressed and chronic restraint stressed rats were observed to determine the differential expression of genes in populations of Wistar-Kyoto rats. 125 genes within the amygdala were determined to be differential between the two testing conditions.
Authors:
Andrus BM, Blizinsky K, Vedell PT, Dennis K, Shukla PK, Schaffer DJ, Radulovic J, Churchill GA, Redei EE
The testing of different hypotheses of the etiology of depression was performed. Two Wistar-Kyoto (WKY) rat models were compared: WKY More Immobile (WMI) being the substrain model that displayed high immobility/dispair-like behaviors; WKY Less Immobile (WLI) being the substrain model that displayed no depressive-like behaviors. The two strains were tested or their depressive-like behaviors using a forced swim test. 27 differentially expressed genes were observed in the amygdala.
Authors:
Andrus BM, Blizinsky K, Vedell PT, Dennis K, Shukla PK, Schaffer DJ, Radulovic J, Churchill GA, Redei EE
The testing of different hypotheses of the etiology of depression was performed. Two Wistar-Kyoto (WKY) rat models were compared: WKY More Immobile (WMI) being the substrain model that displayed high immobility/dispair-like behaviors; WKY Less Immobile (WLI) being the substrain model that displayed no depressive-like behaviors. The two strains were tested or their depressive-like behaviors using a forced swim test. 27 differentially expressed genes were observed in the hippocampus.
Authors:
Andrus BM, Blizinsky K, Vedell PT, Dennis K, Shukla PK, Schaffer DJ, Radulovic J, Churchill GA, Redei EE
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