QTL Associated with Renal pathology. On Chromosome 1 with a LOD score= 2.2, p-value =. From a(n) intercross of QTL Associated with Renal pathology. On Chromosome 15 with a LOD score= 2.5, p-value =. From a(n) intercross of
Authors:
Herrera VL, Tsikoudakis A, Ponce LR, Matsubara Y, Ruiz-Opazo N
QTL Associated with IL-6 level. On Chromosome 14 with a LOD score= 3.7, p-value =. From a(n) intercross of E3xDA QTL Associated with Neuroinflammation. On Chromosome 15 with a LOD score= 3.5, p-value =. From a(n) of
Authors:
Diez M, Abdelmagid N, Harnesk K, Ström M, Lidman O, Swanberg M, Lindblom R, Al-Nimer F, Jagodic M, Olsson T, Piehl F
H3 dopaminylation at glutamine 5 (H3Q5dop) plays a critical role in heroin-mediated transcriptional plasticity in midbrain regions, particularly the VTA. In rats undergoing abstinence from heroin self-administration (SA), we found acute and persistent accumulation of H3Q5dop in VTA. Attenuation of H3Q5dop during abstinence induced persistent changes in gene expression programs associated with neuronal signaling and dopaminergic function in heroin abstinence and led to reduced heroin-seeking behavior. Interestingly, the observed changes in molecular pathways after heroin SA showed significant yet reversed overlap with the same genes altered in cocaine SA.
Authors:
Sasha L Fulton, Swarup Mitra, Ashley E Lepack, Jennifer A Martin, Andrew F Stewart, Jacob Converse, Mason Hochstetler, David M Dietz, Ian Maze
The aim of this study was to perform a GWAS in the heterogenous stock (HS) rat population to identify genomic regions that harbor variants responsible for the variation in intraocular pressure (IOP). We performed a GWAS for the IOP phenotype using a linear mixed model and used permutation to determine a genome-wide significance threshold. Both male and female HS rats (N=1,812) were used in the study. Genotyping-by-sequencing was used to obtain ~3.5M single nucleotide polymorphisms from each individual. We performed eQTL analysis using 51 rat eye samples. Log allelic fold change (aFC) of the eQTL used as a measure of effect size.
Authors:
Samuel Fowler, Tengfei Wang, Daniel Munro, Aman Kumar, Apurva S Chitre, T J Hollingsworth, Angel Garcia Martinez, Celine L St Pierre, Hannah Bimschleger, Jianjun Gao, Riyan Cheng, Pejman Mohammadi, Hao Chen, Abraham A Palmer, Oksana Polesskaya, Monica M Jablonski
Striatum Gene Expression Correlates for ENTRIES_CLOSED measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ENTRIES_CLOSED measures Number of entries into closed arms of plus maze under the domain Ethanol. The correlates were thresholded at a p-value of less than 0.001.
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