Genome-wide association studies are conducted of two human cohorts, one group demonstrating nicotine dependence and another successfully quitting smoking. Study shows that some genetic components associated with the ability to quit overlap while many do not overlap. To perform the study, DNA samples were obtained from NIH volunteers and the allelic frequencies of the samples were analyzed using Affymetrix array analysis. This gene set comprises 290 genes associated with nicotine dependence.
Authors:
Drgon T, Montoya I, Johnson C, Liu QR, Walther D, Hamer D, Uhl GR
Genes associated with Homo sapiens that interact with the MeSH term 'Tretinoin' (D014212). Incorporates data from 1 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'Tobacco Smoke Pollution' (D014028). Incorporates data from 5 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
Genes associated with Homo sapiens that interact with the MeSH term 'arsenic trioxide' (C006632). Incorporates data from 3 publications curated by the Comparative Toxicogenomics Database (CTD). ODE Gene scores represent number of supporting publications per gene.
JNK_DN.V1_UP
Genes up-regulated in JNK inhibitor-treated (SP600125<a href='http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=8515'>[PubChem=8515]</a>) keratinocytes.
c6 - Genesets containing oncogenic signatures defined directly from microarray gene expression data from cancer gene perturbations.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
GSE3982_DC_VS_BCELL_DN
Genes down-regulated in comparison of dendritic cells (DC) versus B cells.
c7 - Genesets containing immunologic signatures defined directly from microarray gene expression data from immunologic studies.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
GSE22886_NAIVE_CD4_TCELL_VS_MONOCYTE_UP
Genes up-regulated in comparison of naive CD4 <a href='http://www.ncbi.nlm.nih.gov/gene/920'>[GeneID=920]</a> T cells versus day 0 monocytes.
c7 - Genesets containing immunologic signatures defined directly from microarray gene expression data from immunologic studies.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
GSE6269_HEALTHY_VS_STREP_PNEUMO_INF_PBMC_DN
Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from healthy donors versus PBMC from patients with acute S. pneumoniae infection.
c7 - Genesets containing immunologic signatures defined directly from microarray gene expression data from immunologic studies.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
GSE34205_HEALTHY_VS_RSV_INF_INFANT_PBMC_DN
Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from healthy donors versus PBMCs from infanct with acute RSV infection.
c7 - Genesets containing immunologic signatures defined directly from microarray gene expression data from immunologic studies.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
STK33_SKM_DN
Genes down-regulated in SKM-1 cells (AML) after knockdown of STK33 <a href='http://www.ncbi.nlm.nih.gov/gene/65975'>[GeneID=65975]</a> by RNAi.
c6 - Genesets containing oncogenic signatures defined directly from microarray gene expression data from cancer gene perturbations.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
GSE29615_CTRL_VS_LAIV_FLU_VACCINE_PBMC_UP
Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those post-vaccination.
c7 - Genesets containing immunologic signatures defined directly from microarray gene expression data from immunologic studies.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
chr8p23
Genes in cytogenetic band chr8p23
c1 - Positional genesets for each human chromosome and cytogenetic band.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
PTEN_DN.V1_DN
Genes down-regulated upon knockdown of PTEN <a href='http://www.ncbi.nlm.nih.gov/gene/5728'>[GeneID=5728]</a> by RNAi.
c6 - Genesets containing oncogenic signatures defined directly from microarray gene expression data from cancer gene perturbations.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
GSE3982_DC_VS_CENT_MEMORY_CD4_TCELL_DN
Genes down-regulated in comparison of dendritic cells (DC) versus central memory CD4 <a href='http://www.ncbi.nlm.nih.gov/gene/920'>[GeneID=920]</a> T cells.
c7 - Genesets containing immunologic signatures defined directly from microarray gene expression data from immunologic studies.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
GSE26928_EFF_MEM_VS_CENTR_MEM_CD4_TCELL_DN
Genes down-regulated in comparison of CD4 <a href='http://www.ncbi.nlm.nih.gov/gene/920'>[GeneID=920]</a> effector memory T cells versus CD4 <a href='http://www.ncbi.nlm.nih.gov/gene/920'>[GeneID=920]</a> central memory T cells.
c7 - Genesets containing immunologic signatures defined directly from microarray gene expression data from immunologic studies.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
Pathway Commons (PC) Geneset. This geneset contains genes that participate in the "Homo sapiens" pathway. This set was automatically constructed using the PC API.
The original source of this geneset is miRTarBase.
gene2pc v. 0.1.0
Last updated 2015.08.31
The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
Generated by gene2mesh v. 1.1.1
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Generated by gene2mesh v. 1.1.1
A broad class of substances encompassing all those that do not include carbon and its derivatives as their principal elements. However, carbides, carbonates, cyanides, cyanates, and carbon disulfide are included in this class.
Generated by gene2mesh v. 1.1.1
GeneWeaver