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Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
Pathway Commons (PC) Geneset. This geneset contains genes that participate in the "Homo sapiens" pathway. This set was automatically constructed using the PC API.
The original source of this geneset is miRTarBase.
gene2pc v. 0.1.0
Last updated 2015.08.31
Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.
Generated by gene2mesh v. 1.1.1
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
Generated by gene2mesh v. 1.1.1
The processes, properties and biological objects that are involved in maintaining, expressing, and transmitting from one organism to another, genetically encoded traits.
Generated by gene2mesh v. 1.1.1
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Generated by gene2mesh v. 1.1.1
Abnormal anatomical or physiological conditions and objective or subjective manifestations of disease, not classified as disease or syndrome.
Generated by gene2mesh v. 1.1.1
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Generated by gene2mesh v. 1.1.1
Endogenously-synthesized compounds that influence biological processes not otherwise classified under ENZYMES; HORMONES or HORMONE ANTAGONISTS.
Generated by gene2mesh v. 1.1.1
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Generated by gene2mesh v. 1.1.1
Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
Generated by gene2mesh v. 1.1.1
A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.
Generated by gene2mesh v. 1.1.1
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Generated by gene2mesh v. 1.1.1
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN). The EFO term Stevens-Johnson syndrome, toxic epidermal necrolysis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
M Tohkin, N Kaniwa, Y Saito, E Sugiyama, K Kurose, J Nishikawa, R Hasegawa, M Aihara, K Matsunaga, M Abe, H Furuya, Y Takahashi, H Ikeda, M Muramatsu, M Ueta, C Sotozono, S Kinoshita, Z Ikezawa
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Atopic dermatitis. The EFO term atopic eczema was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
L Paternoster, M Standl, CM Chen, A Ramasamy, K Bønnelykke, L Duijts, MA Ferreira, AC Alves, JP Thyssen, E Albrecht, H Baurecht, B Feenstra, PM Sleiman, P Hysi, NM Warrington, I Curjuric, R Myhre, JA Curtin, MM Groen-Blokhuis, M Kerkhof, A Sääf, A Franke, D Ellinghaus, R Fölster-Holst, E Dermitzakis, SB Montgomery, H Prokisch, K Heim, AL Hartikainen, A Pouta, J Pekkanen, AI Blakemore, JL Buxton, M Kaakinen, DL Duffy, PA Madden, AC Heath, GW Montgomery, PJ Thompson, MC Matheson, P Le Souëf, B St Pourcain, GD Smith, J Henderson, JP Kemp, NJ Timpson, P Deloukas, SM Ring, HE Wichmann, M Müller-Nurasyid, N Novak, N Klopp, E Rodríguez, W McArdle, A Linneberg, T Menné, EA Nohr, A Hofman, AG Uitterlinden, CM van Duijn, F Rivadeneira, JC de Jongste, RJ van der Valk, M Wjst, R Jogi, F Geller, HA Boyd, JC Murray, C Kim, F Mentch, M March, M Mangino, TD Spector, V Bataille, CE Pennell, PG Holt, P Sly, CM Tiesler, E Thiering, T Illig, M Imboden, W Nystad, A Simpson, JJ Hottenga, D Postma, GH Koppelman, HA Smit, C Söderhäll, B Chawes, E Kreiner-Møller, H Bisgaard, E Melén, DI Boomsma, A Custovic, B Jacobsson, NM Probst-Hensch, LJ Palmer, D Glass, H Hakonarson, M Melbye, DL Jarvis, VW Jaddoe, C Gieger, DP Strachan, NG Martin, MR Jarvelin, J Heinrich, DM Evans, S Weidinger
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Myositis. The EFO term myositis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
FW Miller, W Chen, TP O'Hanlon, RG Cooper, J Vencovsky, LG Rider, K Danko, LR Wedderburn, IE Lundberg, LM Pachman, AM Reed, SR Ytterberg, L Padyukov, A Selva-O'Callaghan, TR Radstake, DA Isenberg, H Chinoy, WE Ollier, P Scheet, B Peng, A Lee, J Byun, JA Lamb, PK Gregersen, CI Amos
Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use disorder. Transcriptomic profile of 20 control subjects and 20 OUD subjects in brain region DLPFC and NAC. Analyzed using GEO2R (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174409) separately for each brain region, comparing OUD and control samples.
Authors:
Xiangning Xue, Wei Zong, Jill R Glausier, Sam-Moon Kim, Micah A Shelton, BaDoi N Phan, Chaitanya Srinivasan, Andreas R Pfenning, George C Tseng, David A Lewis, Marianne L Seney, Ryan W Logan
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