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QTL for alcohol consumption on Chr2 at D2Mit148 (183.66 Mbp , Build 37)
Description:
alcohol consumption spans 158.66 - 208.66 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Vadasz C, Saito M, Gyetvai B, Mikics E, Vadasz C 2nd
Voluntary alcohol consumption QTL 1. In the AXB/BXA RI series, significant linkage to alcohol preference mapped to 107 cM on mouse Chromosome 2 near D2Mit74 (LOD=6.13). This locus accounts for 30% of the variance in male and female mice and is named Vacq1 (voluntary alcohol consumption QTL 1). The Vacq1 QTL interval is defined by markers D2Mit148 (105 cM) and D2Mit266 (109 cM). C57BL/6J-derived alleles at Vacq1 confer increased alcohol consumption. Potential candidate genes for Vacq1 are Ntsr1 (107 cM) and Chrna4 (108 cM). Vacq1 appears to be influenced by a locus on mouse Chromosome 15 named Vacq2 (voluntary alcohol consumption QTL 2). Animals homozygous for C57BL/6J-derived alleles at both Vacq1 and Vacq2 exhibit significantly increased alcohol preference.