A CXC chemokine that is chemotactic for T-LYMPHOCYTES and MONOCYTES. It has specificity for CXCR4 RECEPTORS. Two isoforms of CXCL12 are produced by alternative mRNA splicing.
Generated by gene2mesh v. 1.1.1
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "CXCL12-activated CXCR4 signaling pathway", which is defined as "A series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.12.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
CXCR receptors with specificity for CXCL12 CHEMOKINE. The receptors may play a role in HEMATOPOIESIS regulation and can also function as coreceptors for the HUMAN IMMUNODEFICIENCY VIRUS.
Generated by gene2mesh v. 1.1.1
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Myocardial infarction (early onset). The EFO term myocardial infarction was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
S Kathiresan, BF Voight, S Purcell, K Musunuru, D Ardissino, PM Mannucci, S Anand, JC Engert, NJ Samani, H Schunkert, J Erdmann, MP Reilly, DJ Rader, T Morgan, JA Spertus, M Stoll, D Girelli, PP McKeown, CC Patterson, DS Siscovick, CJ O'Donnell, R Elosua, L Peltonen, V Salomaa, SM Schwartz, O Melander, D Altshuler, D Ardissino, PA Merlini, C Berzuini, L Bernardinelli, F Peyvandi, M Tubaro, P Celli, M Ferrario, R Fetiveau, N Marziliano, G Casari, M Galli, F Ribichini, M Rossi, F Bernardi, P Zonzin, A Piazza, PM Mannucci, SM Schwartz, DS Siscovick, J Yee, Y Friedlander, R Elosua, J Marrugat, G Lucas, I Subirana, J Sala, R Ramos, S Kathiresan, JB Meigs, G Williams, DM Nathan, CA MacRae, CJ O'Donnell, V Salomaa, AS Havulinna, L Peltonen, O Melander, G Berglund, BF Voight, S Kathiresan, JN Hirschhorn, R Asselta, S Duga, M Spreafico, K Musunuru, MJ Daly, S Purcell, BF Voight, S Purcell, J Nemesh, JM Korn, SA McCarroll, SM Schwartz, J Yee, S Kathiresan, G Lucas, I Subirana, R Elosua, A Surti, C Guiducci, L Gianniny, D Mirel, M Parkin, N Burtt, SB Gabriel, NJ Samani, JR Thompson, PS Braund, BJ Wright, AJ Balmforth, SG Ball, A Hall, H Schunkert, J Erdmann, P Linsel-Nitschke, W Lieb, A Ziegler, I König, C Hengstenberg, M Fischer, K Stark, A Grosshennig, M Preuss, HE Wichmann, S Schreiber, H Schunkert, NJ Samani, J Erdmann, W Ouwehand, C Hengstenberg, P Deloukas, M Scholz, F Cambien, MP Reilly, M Li, Z Chen, R Wilensky, W Matthai, A Qasim, HH Hakonarson, J Devaney, MS Burnett, AD Pichard, KM Kent, L Satler, JM Lindsay, R Waksman, CW Knouff, DM Waterworth, MC Walker, V Mooser, SE Epstein, DJ Rader, T Scheffold, K Berger, M Stoll, A Huge, D Girelli, N Martinelli, O Olivieri, R Corrocher, T Morgan, JA Spertus, P McKeown, CC Patterson, H Schunkert, E Erdmann, P Linsel-Nitschke, W Lieb, A Ziegler, IR König, C Hengstenberg, M Fischer, K Stark, A Grosshennig, M Preuss, HE Wichmann, S Schreiber, H Hólm, G Thorleifsson, U Thorsteinsdottir, K Stefansson, JC Engert, R Do, C Xie, S Anand, S Kathiresan, D Ardissino, PM Mannucci, D Siscovick, CJ O'Donnell, NJ Samani, O Melander, R Elosua, L Peltonen, V Salomaa, SM Schwartz, D Altshuler
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "chemokine (C-X-C motif) ligand 12 signaling pathway", which is defined as "A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.12.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Striatum Gene Expression Correlates for ROTASALINE_DIFF measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The ROTASALINE_DIFF measures Difference in time on rotarod between saline and ethanol under the domain Ethanol. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for ADUL_RMS_BRDU measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The ADUL_RMS_BRDU measures Neurogenesis- BrdU labeled new neurons in Adult Rostral Migratory Stream 1 hr post BrdU under the domain Neurogenesis. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for AMCNT180 measured in BXD RI Females & Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The AMCNT180 measures Morphine photocell counts minutes 165-180 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Striatum Gene Expression Correlates for AMCNT180 measured in BXD RI Males obtained using GeneNetwork Striatum M430V2 (Apr05) RMA. The AMCNT180 measures Morphine photocell counts minutes 165-180 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for AMCNT60 measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The AMCNT60 measures Morphine photocell counts minutes 45-60 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for AMCNT75 measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The AMCNT75 measures Morphine photocell counts minutes 60-75 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for AMDIST120 measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The AMDIST120 measures Morphine distance (cm) travelled minutes 105-120 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for OF_REAR_10_15 measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The OF_REAR_10_15 measures Open Field - Total rears 10-15 minutes under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for OF_REAR_15_20 measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The OF_REAR_15_20 measures Open Field - Total rears 15-20 minutes under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Hippocampus Gene Expression Correlates for OF_REARS measured in BXD RI Females obtained using GeneNetwork Hippocampus Consortium M430v2 (Jun06) RMA. The OF_REARS measures Open Field - Total number of Rears under the domain Basal Behavior. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for VERCNT30 measured in BXD RI Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The VERCNT30 measures Morphine vertical activity counts minutes 15-30 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
The genes that were significantly changed in expression in each disease are summarized in Table 1. Of interest is the upregu- lation of CCL11 (also known as eotaxin) exclusively in UC. While chemokines play a role in all inflammatory diseases, celiac disease is relatively independent of chemokine expres- sion. A unique feature for UC and CD is the increased transcript levels for the proinflammatory cytokine IL-1
Authors:
van der Pouw Kraan TC, Zwiers A, Mulder CJ, Kraal G, Bouma G
Genes with a mean fold change > 1.5 or < 0.7 were selected and annotated. Values are taken from microarray analysis and represent mean ratios of alcoholic cases compared with matched control cases(n = 6). P values were from t-test; from Flatscher-Bader et al., 2005
Authors:
Flatscher-Bader T, van der Brug M, Hwang JW, Gochee PA, Matsumoto I, Niwa S, Wilce PA
QTL for differences in cocaine responsiveness on Chr6 at D6Nds2 (93.28 Mbp , Build 37)
Description:
differences in cocaine responsiveness spans 68.28 - 118.28 Mbp (NCBI Build 37) on Chr6. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
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