Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "corticotropin-releasing hormone receptor 1 binding", which is defined as "Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Bone mineral density (hip). The EFO term bone density was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
F Rivadeneira, U Styrkársdottir, K Estrada, BV Halldórsson, YH Hsu, JB Richards, MC Zillikens, FK Kavvoura, N Amin, YS Aulchenko, LA Cupples, P Deloukas, S Demissie, E Grundberg, A Hofman, A Kong, D Karasik, JB van Meurs, B Oostra, T Pastinen, HA Pols, G Sigurdsson, N Soranzo, G Thorleifsson, U Thorsteinsdottir, FM Williams, SG Wilson, Y Zhou, SH Ralston, CM van Duijn, T Spector, DP Kiel, K Stefansson, JP Ioannidis, AG Uitterlinden
QTL associated with Crhr1 transcript abundance QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (4955366)
QTL associated with Crhr1 transcript abundance QTL 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (82010921)
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Neuroticism. The EFO term neuroticism measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
DJ Smith, V Escott-Price, G Davies, ME Bailey, L Colodro-Conde, J Ward, A Vedernikov, R Marioni, B Cullen, D Lyall, SP Hagenaars, DC Liewald, M Luciano, CR Gale, SJ Ritchie, C Hayward, B Nicholl, B Bulik-Sullivan, M Adams, B Couvy-Duchesne, N Graham, D Mackay, J Evans, BH Smith, DJ Porteous, SE Medland, NG Martin, P Holmans, AM McIntosh, JP Pell, IJ Deary, MC O'Donovan
"Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system." [PMID:15134857]
"Interacting selectively and non-covalently with the corticotropin-releasing hormone receptor 1 (CRHR1). CRHR1 is the major subtype in the pituitary corticotroph, and mediates the stimulatory actions of corticotropin-releasing hormone on corticotropin hormone secretion. CRHR1 are also located in cortical areas of the brain, cerebellum and limbic system." [PMID:15134857]
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Multiple system atrophy (pathologically confirmed). The EFO term multiple system atrophy was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Sailer, SW Scholz, MA Nalls, C Schulte, M Federoff, TR Price, A Lees, OA Ross, DW Dickson, K Mok, NE Mencacci, L Schottlaender, V Chelban, H Ling, SS O'Sullivan, NW Wood, BJ Traynor, L Ferrucci, HJ Federoff, TR Mhyre, HR Morris, G Deuschl, N Quinn, H Widner, A Albanese, J Infante, KP Bhatia, W Poewe, W Oertel, GU Höglinger, U Wüllner, S Goldwurm, MT Pellecchia, J Ferreira, E Tolosa, BR Bloem, O Rascol, WG Meissner, JA Hardy, T Revesz, JL Holton, T Gasser, GK Wenning, AB Singleton, H Houlden
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Alzheimer's disease in APOE e4- carriers. The EFO term Alzheimers disease was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
G Jun, CA Ibrahim-Verbaas, M Vronskaya, JC Lambert, J Chung, AC Naj, BW Kunkle, LS Wang, JC Bis, C Bellenguez, D Harold, KL Lunetta, AL Destefano, B Grenier-Boley, R Sims, GW Beecham, AV Smith, V Chouraki, KL Hamilton-Nelson, MA Ikram, N Fievet, N Denning, ER Martin, H Schmidt, Y Kamatani, ML Dunstan, O Valladares, AR Laza, D Zelenika, A Ramirez, TM Foroud, SH Choi, A Boland, T Becker, WA Kukull, SJ van der Lee, F Pasquier, C Cruchaga, D Beekly, AL Fitzpatrick, O Hanon, M Gill, R Barber, V Gudnason, D Campion, S Love, DA Bennett, N Amin, C Berr, M Tsolaki, JD Buxbaum, OL Lopez, V Deramecourt, NC Fox, LB Cantwell, L Tárraga, C Dufouil, J Hardy, PK Crane, G Eiriksdottir, D Hannequin, R Clarke, D Evans, TH Mosley, L Letenneur, C Brayne, W Maier, P De Jager, V Emilsson, JF Dartigues, H Hampel, MI Kamboh, RF de Bruijn, C Tzourio, P Pastor, EB Larson, JI Rotter, MC O'Donovan, TJ Montine, MA Nalls, S Mead, EM Reiman, PV Jonsson, C Holmes, PH St George-Hyslop, M Boada, P Passmore, JR Wendland, R Schmidt, K Morgan, AR Winslow, JF Powell, M Carasquillo, SG Younkin, J Jakobsdóttir, JS Kauwe, KC Wilhelmsen, D Rujescu, MM Nöthen, A Hofman, L Jones, JL Haines, BM Psaty, C Van Broeckhoven, P Holmans, LJ Launer, R Mayeux, M Lathrop, AM Goate, V Escott-Price, S Seshadri, MA Pericak-Vance, P Amouyel, J Williams, CM van Duijn, GD Schellenberg, LA Farrer
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Head circumference (infant). The EFO term infant head circumference was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
HR Taal, B St Pourcain, E Thiering, S Das, DO Mook-Kanamori, NM Warrington, M Kaakinen, E Kreiner-Møller, JP Bradfield, RM Freathy, F Geller, M Guxens, DL Cousminer, M Kerkhof, NJ Timpson, MA Ikram, LJ Beilin, K Bønnelykke, JL Buxton, P Charoen, BL Chawes, J Eriksson, DM Evans, A Hofman, JP Kemp, CE Kim, N Klopp, J Lahti, SJ Lye, G McMahon, FD Mentch, M Müller-Nurasyid, PF O'Reilly, I Prokopenko, F Rivadeneira, EA Steegers, J Sunyer, C Tiesler, H Yaghootkar, MM Breteler, C Decarli, MM Breteler, S Debette, M Fornage, V Gudnason, LJ Launer, A van der Lugt, TH Mosley, S Seshadri, AV Smith, MW Vernooij, AI Blakemore, RM Chiavacci, B Feenstra, J Fernandez-Banet, SF Grant, AL Hartikainen, AJ van der Heijden, C Iñiguez, M Lathrop, WL McArdle, A Mølgaard, JP Newnham, LJ Palmer, A Palotie, A Pouta, SM Ring, U Sovio, M Standl, AG Uitterlinden, HE Wichmann, NH Vissing, C DeCarli, CM van Duijn, MI McCarthy, GH Koppelman, X Estivill, AT Hattersley, M Melbye, H Bisgaard, CE Pennell, E Widen, H Hakonarson, GD Smith, J Heinrich, MR Jarvelin, VW Jaddoe
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Subcortical brain region volumes. The EFO term intra cranial volume was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
DP Hibar, JL Stein, ME Renteria, A Arias-Vasquez, S Desrivières, N Jahanshad, R Toro, K Wittfeld, L Abramovic, M Andersson, BS Aribisala, NJ Armstrong, M Bernard, MM Bohlken, MP Boks, J Bralten, AA Brown, MM Chakravarty, Q Chen, CR Ching, G Cuellar-Partida, A den Braber, S Giddaluru, AL Goldman, O Grimm, T Guadalupe, J Hass, G Woldehawariat, AJ Holmes, M Hoogman, D Janowitz, T Jia, S Kim, M Klein, B Kraemer, PH Lee, LM Olde Loohuis, M Luciano, C Macare, KA Mather, M Mattheisen, Y Milaneschi, K Nho, M Papmeyer, A Ramasamy, SL Risacher, R Roiz-Santiañez, EJ Rose, A Salami, PG Sämann, L Schmaal, AJ Schork, J Shin, LT Strike, A Teumer, MM van Donkelaar, KR van Eijk, RK Walters, LT Westlye, CD Whelan, AM Winkler, MP Zwiers, S Alhusaini, L Athanasiu, S Ehrlich, MM Hakobjan, CB Hartberg, UK Haukvik, AJ Heister, D Hoehn, D Kasperaviciute, DC Liewald, LM Lopez, RR Makkinje, M Matarin, MA Naber, DR McKay, M Needham, AC Nugent, B Pütz, NA Royle, L Shen, E Sprooten, D Trabzuni, SS van der Marel, KJ van Hulzen, E Walton, C Wolf, L Almasy, D Ames, S Arepalli, AA Assareh, ME Bastin, H Brodaty, KB Bulayeva, MA Carless, S Cichon, A Corvin, JE Curran, M Czisch, GI de Zubicaray, A Dillman, R Duggirala, TD Dyer, S Erk, IO Fedko, L Ferrucci, TM Foroud, PT Fox, M Fukunaga, JR Gibbs, HH Göring, RC Green, S Guelfi, NK Hansell, CA Hartman, K Hegenscheid, A Heinz, DG Hernandez, DJ Heslenfeld, PJ Hoekstra, F Holsboer, G Homuth, JJ Hottenga, M Ikeda, CR Jack, M Jenkinson, R Johnson, R Kanai, M Keil, JW Kent, P Kochunov, JB Kwok, SM Lawrie, X Liu, DL Longo, KL McMahon, E Meisenzahl, I Melle, S Mohnke, GW Montgomery, JC Mostert, TW Mühleisen, MA Nalls, TE Nichols, LG Nilsson, MM Nöthen, K Ohi, RL Olvera, R Perez-Iglesias, GB Pike, SG Potkin, I Reinvang, S Reppermund, M Rietschel, N Romanczuk-Seiferth, GD Rosen, D Rujescu, K Schnell, PR Schofield, C Smith, VM Steen, JE Sussmann, A Thalamuthu, AW Toga, BJ Traynor, J Troncoso, JA Turner, MC Valdés Hernández, D van 't Ent, M van der Brug, NJ van der Wee, MJ van Tol, DJ Veltman, TH Wassink, E Westman, RH Zielke, AB Zonderman, DG Ashbrook, R Hager, L Lu, FJ McMahon, DW Morris, RW Williams, HG Brunner, RL Buckner, JK Buitelaar, W Cahn, VD Calhoun, GL Cavalleri, B Crespo-Facorro, AM Dale, GE Davies, N Delanty, C Depondt, S Djurovic, WC Drevets, T Espeseth, RL Gollub, BC Ho, W Hoffmann, N Hosten, RS Kahn, S Le Hellard, A Meyer-Lindenberg, B Müller-Myhsok, M Nauck, L Nyberg, M Pandolfo, BW Penninx, JL Roffman, SM Sisodiya, JW Smoller, H van Bokhoven, NE van Haren, H Völzke, H Walter, MW Weiner, W Wen, T White, I Agartz, OA Andreassen, J Blangero, DI Boomsma, RM Brouwer, DM Cannon, MR Cookson, EJ de Geus, IJ Deary, G Donohoe, G Fernández, SE Fisher, C Francks, DC Glahn, HJ Grabe, O Gruber, J Hardy, R Hashimoto, HE Hulshoff Pol, EG Jönsson, I Kloszewska, S Lovestone, VS Mattay, P Mecocci, C McDonald, AM McIntosh, RA Ophoff, T Paus, Z Pausova, M Ryten, PS Sachdev, AJ Saykin, A Simmons, A Singleton, H Soininen, JM Wardlaw, ME Weale, DR Weinberger, HH Adams, LJ Launer, S Seiler, R Schmidt, G Chauhan, CL Satizabal, JT Becker, L Yanek, SJ van der Lee, M Ebling, B Fischl, WT Longstreth, D Greve, H Schmidt, P Nyquist, LN Vinke, CM van Duijn, L Xue, B Mazoyer, JC Bis, V Gudnason, S Seshadri, MA Ikram, NG Martin, MJ Wright, G Schumann, B Franke, PM Thompson, SE Medland
Data from GEO GSE194368 and analyzed using GEO2R, only top gene shown. Authors identified transcriptional adaptations of GR signaling in the amygdala of humans with OUD. Thus, GRs, their coregulators and downstream systems may represent viable therapeutic targets to treat the “stress side” of OUD.
Authors:
Stephanie A Carmack, Janaina C M Vendruscolo, M Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D Bosse, Daniele Mercatelli, Federico M Giorgi, Yu Fu, Anthony J Hinrich, Francine M Jodelka, Karen Ling, Robert O Messing, Randall T Peterson, Frank Rigo, Scott Edwards, Pietro P Sanna, Marisela Morales, Michelle L Hastings, George F Koob, Leandro F Vendruscolo
The dataset used in this study (Bulk RNA-Seq) was previously published and can be found at NCBI GEO (GSE182321), this analysis was conducted by GEO2R to compare control and OUD samples, only top differentially expressed genes are reported. To understand mechanisms and identify potential targets for intervention in the current crisis of opioid use disorder (OUD), postmortem brains represent an under-utilized resource. To refine previously reported gene signatures of neurobiological alterations in OUD from the dorsolateral prefrontal cortex (Brodmann Area 9, BA9), we explored the role of microRNAs (miRNA) as powerful epigenetic regulators of gene function.
Using a two-stage process, several genes were initially identified using microarray analyses of cerebellar tissue from ethanol-treated PKCgamma mutant and wild-type mice. This geneset consists of genes related to PKCgamma wild-type expression changes due to chronic ethanol diet.
Authors:
Bowers BJ, Radcliffe RA, Smith AM, Miyamoto-Ditmon J, Wehner JM
This gene set comprises 17 ethanol-dependence genes that were downregulated in the PKC-gamma mutant mice tested during the experiment. Background: Study shows that PKC-gamma wild-type mice develop tolerance to the sedative-hypnotic effects of ethanol after chronic ethanol treatment but mutant mice do not, making these genotypes a suitable model for identifying changes in gene expression related developing tolerance toward ethanol.
Authors:
Bowers BJ, Radcliffe RA, Smith AM, Miyamoto-Ditmon J, Wehner JM
Neocortex Gene Expression Correlates for NEPCOUNT30 measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The NEPCOUNT30 measures Novel environment locomotion (activity beam breaks) 15-30 min in the periphery under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Neocortex Gene Expression Correlates for NEPCOUNT45 measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The NEPCOUNT45 measures Novel environment locomotion (activity beam breaks) 30-45 min in the periphery under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Neocortex Gene Expression Correlates for NEPDIST30 measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The NEPDIST30 measures Novel environment distance (cm) travelled min 15-30 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Neocortex Gene Expression Correlates for NEPDIST45 measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The NEPDIST45 measures Novel environment locomotion (cm) 30-45 min in the periphery under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for NEPDIST45 measured in BXD RI Females obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The NEPDIST45 measures Novel environment locomotion (cm) 30-45 min in the periphery under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Whole Brain Gene Expression Correlates for NEVCOUNT60 measured in BXD RI Females & Males obtained using INIA Brain mRNA M430 (Jun06) RMA. The NEVCOUNT60 measures Novel environment vertical activity counts minutes 45-60 under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Neocortex Gene Expression Correlates for NOVEL_ACOUNT_1 measured in BXD RI Females & Males obtained using GeneNetwork Neocortex ILM6v1.1 (Feb08) RankInv. The NOVEL_ACOUNT_1 measures Open Field InovelTOTAL locomotion (activity beam breaks) in the center under the domain Morphine. The correlates were thresholded at a p-value of less than 0.001.
GeneWeaver