Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "Golgi to plasma membrane CFTR protein transport", which is defined as "The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.12.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
QTL associated with submucosal gland distribution 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (98698687)
QTL associated with cystic fibrosis body weight 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (164247769)
QTL associated with cystic fibrosis body weight 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (111954645)
QTL associated with cystic fibrosis body weight 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (126237672)
QTL associated with cystic fibrosis body weight 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (117587667)
QTL associated with cystic fibrosis modifier QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (171141303)
QTL associated with cystic fibrosis modifier QTL 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (32308040)
QTL associated with cystic fibrosis modifier QTL 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (118098315)
QTL associated with cystic fibrosis lung disease 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (172807628)
QTL associated with cystic fibrosis lung disease 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (10055276)
QTL associated with cystic fibrosis lung disease 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (126237672)
"Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
"Any process that stops, prevents, or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]
"The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane." [GOC:jl]
A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)
Generated by gene2mesh v. 1.1.1
GWAS: response to methotrexate, chronic childhood arthritis
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Response to methotrexate in juvenile idiopathic arthritis. The EFO term response to methotrexate, chronic childhood arthritis was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
J Cobb, E Cule, H Moncrieffe, A Hinks, S Ursu, F Patrick, L Kassoumeri, E Flynn, M Bulatović, N Wulffraat, B van Zelst, R de Jonge, M Bohm, P Dolezalova, S Hirani, S Newman, P Whitworth, TR Southwood, M De Iorio, LR Wedderburn, W Thomson
The nuclear accumbens (NA) and amygdale (Amyg) of inbred alcohol-preferring mice were examined for differential gene expression and it findings suggest that changes in gene expression in the ACB of iP rats are associated with the reinforcing effects of ethanol (EtOH). This gene set comprises 201 genes that were significantly expressed in the NA during the experiment.
Cerebellum Gene Expression Correlates for HAND_6HOURS measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The HAND_6HOURS measures Handling induced convulsions 6 hrs after ethanol under the domain Ethanol HIC. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for HAND_7HOURS measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The HAND_7HOURS measures Handling induced convulsions 7 hrs after ethanol under the domain Ethanol HIC. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for HIC_SCORE measured in BXD RI Females & Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The HIC_SCORE measures Handling induced convulsion score under the domain Ethanol HIC. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
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