This set describes all genes that have an ATF4 binding peak within 3kb of a transcription start site of the listed genes. Entrez Identifiers were converted to Mouse Genome Informatics Identifiers using the MGI Batch Query (http://www.informatics.jax.org/batch).
Authors:
Jaeseok Han, Sung Hoon Back, Junguk Hur, Yu-Hsuan Lin, Robert Gildersleeve, Jixiu Shan, Celvie L Yuan, Dawid Krokowski, Shiyu Wang, Maria Hatzoglou, Michael S Kilberg, Maureen A Sartor, Randal J Kaufman
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "CHOP-ATF4 complex", which is defined as "A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "ATF1-ATF4 transcription factor complex", which is defined as "Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "ATF4-CREB1 transcription factor complex", which is defined as "Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "ATF1-ATF4 transcription factor complex", which is defined as "Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "ATF4-CREB1 transcription factor complex", which is defined as "Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "PERK-mediated unfolded protein response", which is defined as "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Gene Ontology (GO) gene set. This set contains genes that have been annotated to the GO term "PERK-mediated unfolded protein response", which is defined as "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity." This gene set was automatically constructed using annotation and ontology data provided by GO and only includes annotations with experimental and curatorial evidence codes (EXP, IDA, IPI, IMP, IGI, IEP, TAS, IC). The transitive closure of this term is taken into account using is_a and part_of relationships. For more information: The Gene Ontology Consortium (GOC), http://geneontology.org This gene set was generated using the GeneWeaver GO loader v. 0.2.8.
Authors:
M Ashburner, CA Ball, JA Blake, D Botstein, H Butler, JM Cherry, AP Davis, K Dolinski, SS Dwight, JT Eppig, MA Harris, DP Hill, L Issel-Tarver, A Kasarskis, S Lewis, JC Matese, JE Richardson, M Ringwald, GM Rubin, G Sherlock
Inflammatory cytokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to CBD + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM CBD for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory chemokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to CBD + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM CBD for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory cytokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to CBD + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM CBD for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory chemokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to CBD + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM CBD for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory cytokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to CBD + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM CBD for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory chemokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to CBD + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM CBD for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory cytokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to THC + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM THC for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory chemokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to THC + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM THC for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory cytokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to THC + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM THC for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory chemokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to THC + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM THC for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory cytokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to THC + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM THC for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory chemokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to THC + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM THC for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory cytokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to THC + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM THC for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory chemokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to THC + LPS. Mouse BV-2 microglial cells were pretreated with 10 uM THC for 2 h, followed by addition of LPS for an additional 4 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689."
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory cytokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to CBD. Mouse BV-2 microglial cells were pretreated with 10 uM CBD for 2 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689.
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory chemokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to CBD. Mouse BV-2 microglial cells were pretreated with 10 uM CBD for 2 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689.
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
Inflammatory cytokine and receptor genes that are upregulated in the presence of LPS and differentially expressed in response to THC. Mouse BV-2 microglial cells were pretreated with 10 uM THC for 2 h. Gene expression was evaluated via microarray analysis. Data taken from Supplementary Table S2. Values presented are fold-change. Data available at GEO with accession number GSE70689.
Authors:
Ana Juknat, Maciej Pietr, Ewa Kozela, Neta Rimmerman, Rivka Levy, Fuying Gao, Giovanni Coppola, Daniel Geschwind, Zvi Vogel
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