QTL for nicotine sensitivity on Chr8 at D8Mit124 (13.44 Mbp , Build 37)
Description:
nicotine sensitivity spans 0.00 - 38.44 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
alcohol preference spans 0.00 - 40.29 Mbp (NCBI Build 37) on Chr8. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Bachmanov AA, Reed DR, Li X, Li S, Beauchamp GK, Tordoff MG
QTL associated with Alzheimer's disease modifier 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (27830259)
Authors:
Sebastiani G, Krzywkowski P, Dudal S, Yu M, Paquette J, Malo D, Gervais F, Tremblay P
QTL associated with directional asymmetry QTL 19. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (33127016)
QTL associated with experimental allergic encephalomyelitis susceptibility 24. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25723657)
QTL associated with lung tumor shape-determining 3. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25723657)
QTL associated with macrophage-associated risk inflammatory factor 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (35916997)
QTL associated with nicotine induced locomotor activity 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (14723160)
QTL associated with platelet-binding antibody-associated thrombocytopenia 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (30715154)
Authors:
Ida A, Hirose S, Hamano Y, Kodera S, Jiang Y, Abe M, Zhang D, Nishimura H, Shirai T
QTL associated with proteoglycan induced arthritis 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (34189817)
Authors:
Glant TT, Adarichev VA, Nesterovitch AB, Szanto S, Oswald JP, Jacobs JJ, Firneisz G, Zhang J, Finnegan A, Mikecz K
QTL associated with protection against vaginal candidiasis 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (4976602)
QTL associated with colon tumor susceptibility 8. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (13397210)
Authors:
van Wezel T, Ruivenkamp CA, Stassen AP, Moen CJ, Demant P
QTL associated with susceptibility to lung cancer 20. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (25723657)
List of genes from a moderately conserved WGCNA network in human midbrain tissue (cocaine addicts vs control) - originally derived from mouse (C57) RNA-seq data from Walker et al. 2018 Biological Psych
Microglia depletion and alcohol gene expression logFC
Description:
Alcohol abuse induces changes in microglia morphology and immune function, but whether microglia initiate or simply amplify the harmful effects of alcohol exposure is still a matter of debate. Here, we determine microglia function in acute and voluntary drinking behaviors using a colony-stimulating factor 1 receptor inhibitor (PLX5622). We show that microglia depletion does not alter the sedative or hypnotic effects of acute intoxication. Microglia depletion also does not change the escalation or maintenance of chronic voluntary alcohol consumption. Transcriptomic analysis revealed that although many immune genes have been implicated in alcohol abuse, down regulation of microglia genes does not necessitate changes in alcohol intake. Instead, microglia depletion and chronic alcohol result in compensatory upregulation of alcohol-responsive, reactive astrocyte genes, indicating astrocytes may play a role in regulation of these alcohol behaviors. Taken together, our behavioral and transcriptional data indicate that microglia are not theprimary effector cell responsible for regulation of acute and voluntary alcohol behaviors. Because microglia depletion did not regulate acute or voluntary alcohol behaviors, we hypothesized that these doses were insufficient to activate microglia and recruit them to an effector phenotype. Therefore, we used a model of repeated immune activation using polyinosinic:polycytidylic acid
We investigated the role of microglia in a mouse model of alcohol dependence using a colony stimulating factor 1 receptor inhibitor (PLX5622) to deplete microglia and a chronic intermittent ethanol vapor two-bottle choice drinking procedure. Additionally, we examined anxiety-like behavior during withdrawal. We then analyzed synaptic neuroadaptations in the central nucleus of the amygdala (CeA) and gene expression changes in the medial prefrontal cortex (mPFC) and CeA from the same animals used for behavioral studies.
Authors:
Add Selected GeneSets to Project(s)
Warning: You are not signed in. Adding these genesets to a project will create a guest account for you.
Guest accounts are temporary, and will be removed within 24 hours of creation. Guest accounts can be registered as full accounts, but you cannot associate a guest account with an existing account.
If you already have an account, you should sign into that account before proceeding.