Whole Brain Gene Expression Correlates for ENTRIES_CLOSED measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The ENTRIES_CLOSED measures Number of entries into closed arms of plus maze under the domain Ethanol. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for NOVEL_RATIO measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The NOVEL_RATIO measures Novel Open Field - locomotion in the periphery as a function of total locomotion. under the domain Cocaine. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Cerebellum Gene Expression Correlates for MDMA_ACT_MDA_1 measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The MDMA_ACT_MDA_1 measures Locomotor response of 10 mg/kg MDMA injected on Day 2 under the domain MDMA. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Whole Brain Gene Expression Correlates for PCT_ENTRIES_CLOSED measured in BXD RI Females obtained using INIA Brain mRNA M430 (Jun06) RMA. The PCT_ENTRIES_CLOSED measures Percentage of entries into closed arms of plus maze under the domain Porsolt. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Genes differentially expressed between methamphetamine low drink (MALDR) and methamphetamine high drink (MAHDR) mice from Belknap et al. (2013) , p < 0.01. Data reported in Table S14 for comparison with genes in the present study. Values presented are p-values.
QTL associated with operant response to cocaine in the hybrid mouse diversity panel
Description:
Information on cocaine (or saline—as a control) IVSA in 84 members of the hybrid mouse diversity panel (HMDP), an array of genetically distinct classical or recombinant inbred strains. We found cocaine IVSA to be substantially heritable in this population, with strain-level intake ranging for near 0 to >25 mg/kg/session. Though saline IVSA was also found to be heritable, a modest genetic correlation between cocaine and saline IVSA indicates that operant responding for the cocaine reinforcer was influenced, at least in part, by unique genetic variants. Genome-wide association studies (GWAS) of infusions earned in cocaine and saline groups revealed significant quantitative trait loci (QTL) on Chromosomes 3 and 14 for cocaine, but not saline, IVSA. Positional candidates were further prioritized through use of bulk RNA sequencing data that revealed genes with cis-eQTL and genetic correlation to number of infusions. Additionally, these data identify reference strains with extreme cocaine IVSA phenotypes, revealing them as polygenic models of risk and resilience to cocaine reinforcement. Shown here are Genes in cocaine infusion QTL intervals with cis-eQTL
Authors:
Jared R Bagley, Arshad H Khan, Desmond J Smith, James D Jentsch
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