Cerebellum Gene Expression Correlates for MDMA_ACT_SAL_2 measured in BXD RI Males obtained using SJUT Cerebellum mRNA M430 (Mar05) RMA. The MDMA_ACT_SAL_2 measures Locomotor activity after second saline treatment. under the domain MDMA. The correlates were thresholded at a p-value of less than 0.001.
Authors:
Philip VM, Duvvuru S, Gomero B, Ansah TA, Blaha CD, Cook MN, Hamre KM, Lariviere WR, Matthews DB, Mittleman G, Goldowitz D, Chesler EJ
Genes with particular expression in the Anterodorsal nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Frontal pole, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Accessory olfactory bulb. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Frontal pole, cerebral cortex. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Accessory olfactory bulb, glomerular layer. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Accessory olfactory bulb, granular layer. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Accessory olfactory bulb, mitral layer. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anteroventral nucleus of thalamus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Subfornical organ. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Orbital area, medial part, layer 2/3. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Frontal pole, layer 2/3. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Taenia tecta, dorsal part, layer 2. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Taenia tecta, dorsal part, layer 3. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Taenia tecta, ventral part, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Taenia tecta, ventral part, layer 2. Data represent fold expression difference in structure versus grey matter average expression.
The novel object recognition test was performed on two independent cohorts of mice according to Nilsson et al. (2007). One cohort consisted of mice on the mixed C57BL/6J-129sv background, and the second cohort consisted of mice that had been backcrossed to the C57BL/6J strain for at least four generations. mRNA samples were collected from the hippocampus from FoxO6 mutant and wild-type siblings before (basal) or after novel object learning. 250 ng of total RNA was reverse-transcribed to cDNA, and cDNA was hybridized to the Mouse Gene 1.0 ST array (Affymetrix). 176 genes were up-regulated significantly following object learning in wild-type mice compared with FoxO6 mutant mice (P < 0.05 for interaction between the factors genotype and learning, two-way ANOVA; P < 0.05 for wild-type sibling basal vs. learning, one-way ANOVA).
Authors:
Salih DA, Rashid AJ, Colas D, de la Torre-Ubieta L, Zhu RP, Morgan AA, Santo EE, Ucar D, Devarajan K, Cole CJ, Madison DV, Shamloo M, Butte AJ, Bonni A, Josselyn SA, Brunet A
The current study used two inbred mouse strains, C57BL/6 J and A/J, to investigate the genetics of behavioral responses to fentanyl. Mice were tested for conditioned place preference and fentanyl-induced locomotor activity. C57BL/6J mice formed a conditioned place preference to fentanyl injections and fentanyl increased their activity. Neither effect was noted in A/J mice. We conducted RNA-sequencing on the nucleus accumbens of mice used for fentanyl-induced locomotor activity. Surprisingly, we noted few differentially expressed genes using treatment as the main factor. However many genes differed between strains.
Authors:
Samuel J Harp, Mariangela Martini, Will Rosenow, Larry D Mesner, Hugh Johnson, Charles R Farber, Emilie F Rissman
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