List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Myopia (pathological). The EFO term pathological myopia was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
Q Fan, VA Barathi, CY Cheng, X Zhou, A Meguro, I Nakata, CC Khor, LK Goh, YJ Li, W Lim, CE Ho, F Hawthorne, Y Zheng, D Chua, H Inoko, K Yamashiro, K Ohno-Matsui, K Matsuo, F Matsuda, E Vithana, M Seielstad, N Mizuki, RW Beuerman, ES Tai, N Yoshimura, T Aung, TL Young, TY Wong, YY Teo, SM Saw
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Axial length. The EFO term axial length measurement was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
CY Cheng, M Schache, MK Ikram, TL Young, JA Guggenheim, V Vitart, S MacGregor, VJ Verhoeven, VA Barathi, J Liao, PG Hysi, JE Bailey-Wilson, B St Pourcain, JP Kemp, G McMahon, NJ Timpson, DM Evans, GW Montgomery, A Mishra, YX Wang, JJ Wang, E Rochtchina, O Polasek, AF Wright, N Amin, EM van Leeuwen, JF Wilson, CE Pennell, CM van Duijn, PT de Jong, JR Vingerling, X Zhou, P Chen, R Li, WT Tay, Y Zheng, M Chew, KP Burdon, JE Craig, SK Iyengar, RP Igo, JH Lass, EY Chew, T Haller, E Mihailov, A Metspalu, J Wedenoja, CL Simpson, R Wojciechowski, R Höhn, A Mirshahi, T Zeller, N Pfeiffer, KJ Lackner, T Bettecken, T Meitinger, K Oexle, M Pirastu, L Portas, A Nag, KM Williams, E Yonova-Doing, R Klein, BE Klein, SM Hosseini, AD Paterson, KM Makela, T Lehtimaki, M Kahonen, O Raitakari, N Yoshimura, F Matsuda, LJ Chen, CP Pang, SP Yip, MK Yap, A Meguro, N Mizuki, H Inoko, PJ Foster, JH Zhao, E Vithana, ES Tai, Q Fan, L Xu, H Campbell, B Fleck, I Rudan, T Aung, A Hofman, AG Uitterlinden, G Bencic, CC Khor, H Forward, O Pärssinen, P Mitchell, F Rivadeneira, AW Hewitt, C Williams, BA Oostra, YY Teo, CJ Hammond, D Stambolian, DA Mackey, CC Klaver, TY Wong, SM Saw, PN Baird
chr1q41
Genes in cytogenetic band chr1q41
c1 - Positional genesets for each human chromosome and cytogenetic band.
Molecular Signatures Database (MSigDB) Geneset. This geneset was imported from one of the MSigDB collections.
gene2msig v. 0.1.0
Last updated 2015.08.31
Pathway Commons (PC) Geneset. This geneset contains genes that participate in the "Homo sapiens" pathway. This set was automatically constructed using the PC API.
The original source of this geneset is miRTarBase.
gene2pc v. 0.1.0
Last updated 2015.08.31
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Waist-hip ratio. The EFO term waist-hip ratio was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
IM Heid, AU Jackson, JC Randall, TW Winkler, L Qi, V Steinthorsdottir, G Thorleifsson, MC Zillikens, EK Speliotes, R Mägi, T Workalemahu, CC White, N Bouatia-Naji, TB Harris, SI Berndt, E Ingelsson, CJ Willer, MN Weedon, J Luan, S Vedantam, T Esko, TO Kilpeläinen, Z Kutalik, S Li, KL Monda, AL Dixon, CC Holmes, LM Kaplan, L Liang, JL Min, MF Moffatt, C Molony, G Nicholson, EE Schadt, KT Zondervan, MF Feitosa, T Ferreira, H Lango Allen, RJ Weyant, E Wheeler, AR Wood, K Estrada, ME Goddard, G Lettre, M Mangino, DR Nyholt, S Purcell, AV Smith, PM Visscher, J Yang, SA McCarroll, J Nemesh, BF Voight, D Absher, N Amin, T Aspelund, L Coin, NL Glazer, C Hayward, NL Heard-Costa, JJ Hottenga, A Johansson, T Johnson, M Kaakinen, K Kapur, S Ketkar, JW Knowles, P Kraft, AT Kraja, C Lamina, MF Leitzmann, B McKnight, AP Morris, KK Ong, JR Perry, MJ Peters, O Polasek, I Prokopenko, NW Rayner, S Ripatti, F Rivadeneira, NR Robertson, S Sanna, U Sovio, I Surakka, A Teumer, S van Wingerden, V Vitart, JH Zhao, C Cavalcanti-Proença, PS Chines, E Fisher, JR Kulzer, C Lecoeur, N Narisu, C Sandholt, LJ Scott, K Silander, K Stark, ML Tammesoo, TM Teslovich, NJ Timpson, RM Watanabe, R Welch, DI Chasman, MN Cooper, JO Jansson, J Kettunen, RW Lawrence, N Pellikka, M Perola, L Vandenput, H Alavere, P Almgren, LD Atwood, AJ Bennett, R Biffar, LL Bonnycastle, SR Bornstein, TA Buchanan, H Campbell, IN Day, M Dei, M Dörr, P Elliott, MR Erdos, JG Eriksson, NB Freimer, M Fu, S Gaget, EJ Geus, AP Gjesing, H Grallert, J Grässler, CJ Groves, C Guiducci, AL Hartikainen, N Hassanali, AS Havulinna, KH Herzig, AA Hicks, J Hui, W Igl, P Jousilahti, A Jula, E Kajantie, L Kinnunen, I Kolcic, S Koskinen, P Kovacs, HK Kroemer, V Krzelj, J Kuusisto, K Kvaloy, J Laitinen, O Lantieri, GM Lathrop, ML Lokki, RN Luben, B Ludwig, WL McArdle, A McCarthy, MA Morken, M Nelis, MJ Neville, G Paré, AN Parker, JF Peden, I Pichler, KH Pietiläinen, CG Platou, A Pouta, M Ridderstråle, NJ Samani, J Saramies, J Sinisalo, JH Smit, RJ Strawbridge, HM Stringham, AJ Swift, M Teder-Laving, B Thomson, G Usala, JB van Meurs, GJ van Ommen, V Vatin, CB Volpato, H Wallaschofski, GB Walters, E Widen, SH Wild, G Willemsen, DR Witte, L Zgaga, P Zitting, JP Beilby, AL James, M Kähönen, T Lehtimäki, MS Nieminen, C Ohlsson, LJ Palmer, O Raitakari, PM Ridker, M Stumvoll, A Tönjes, J Viikari, B Balkau, Y Ben-Shlomo, RN Bergman, H Boeing, GD Smith, S Ebrahim, P Froguel, T Hansen, C Hengstenberg, K Hveem, B Isomaa, T Jørgensen, F Karpe, KT Khaw, M Laakso, DA Lawlor, M Marre, T Meitinger, A Metspalu, K Midthjell, O Pedersen, V Salomaa, PE Schwarz, T Tuomi, J Tuomilehto, TT Valle, NJ Wareham, AM Arnold, JS Beckmann, S Bergmann, E Boerwinkle, DI Boomsma, MJ Caulfield, FS Collins, G Eiriksdottir, V Gudnason, U Gyllensten, A Hamsten, AT Hattersley, A Hofman, FB Hu, T Illig, C Iribarren, MR Jarvelin, WH Kao, J Kaprio, LJ Launer, PB Munroe, B Oostra, BW Penninx, PP Pramstaller, BM Psaty, T Quertermous, A Rissanen, I Rudan, AR Shuldiner, N Soranzo, TD Spector, AC Syvanen, M Uda, A Uitterlinden, H Völzke, P Vollenweider, JF Wilson, JC Witteman, AF Wright, GR Abecasis, M Boehnke, IB Borecki, P Deloukas, TM Frayling, LC Groop, T Haritunians, DJ Hunter, RC Kaplan, KE North, JR O'Connell, L Peltonen, D Schlessinger, DP Strachan, JN Hirschhorn, TL Assimes, HE Wichmann, U Thorsteinsdottir, CM van Duijn, K Stefansson, LA Cupples, RJ Loos, I Barroso, MI McCarthy, CS Fox, KL Mohlke, CM Lindgren
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Waist-to-hip ratio adjusted for body mass index. The EFO term BMI-adjusted waist-hip ratio was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
W Wen, N Kato, JY Hwang, X Guo, Y Tabara, H Li, R Dorajoo, X Yang, FJ Tsai, S Li, Y Wu, T Wu, S Kim, X Guo, J Liang, D Shungin, LS Adair, K Akiyama, M Allison, Q Cai, LC Chang, CH Chen, YT Chen, YS Cho, BY Choi, Y Gao, MJ Go, D Gu, BG Han, M He, JE Hixson, Y Hu, T Huang, M Isono, KJ Jung, D Kang, YJ Kim, Y Kita, J Lee, NR Lee, J Lee, Y Wang, JJ Liu, J Long, S Moon, Y Nakamura, M Nakatochi, K Ohnaka, D Rao, J Shi, JW Sull, A Tan, H Ueshima, C Wu, YB Xiang, K Yamamoto, J Yao, X Ye, M Yokota, X Zhang, Y Zheng, L Qi, JI Rotter, SH Jee, D Lin, KL Mohlke, J He, Z Mo, JY Wu, ES Tai, X Lin, T Miki, BJ Kim, F Takeuchi, W Zheng, XO Shu
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Height. The EFO term body height was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
H Lango Allen, K Estrada, G Lettre, SI Berndt, MN Weedon, F Rivadeneira, CJ Willer, AU Jackson, S Vedantam, S Raychaudhuri, T Ferreira, AR Wood, RJ Weyant, AV Segrè, EK Speliotes, E Wheeler, N Soranzo, JH Park, J Yang, D Gudbjartsson, NL Heard-Costa, JC Randall, L Qi, A Vernon Smith, R Mägi, T Pastinen, L Liang, IM Heid, J Luan, G Thorleifsson, TW Winkler, ME Goddard, K Sin Lo, C Palmer, T Workalemahu, YS Aulchenko, A Johansson, MC Zillikens, MF Feitosa, T Esko, T Johnson, S Ketkar, P Kraft, M Mangino, I Prokopenko, D Absher, E Albrecht, F Ernst, NL Glazer, C Hayward, JJ Hottenga, KB Jacobs, JW Knowles, Z Kutalik, KL Monda, O Polasek, M Preuss, NW Rayner, NR Robertson, V Steinthorsdottir, JP Tyrer, BF Voight, F Wiklund, J Xu, JH Zhao, DR Nyholt, N Pellikka, M Perola, JR Perry, I Surakka, ML Tammesoo, EL Altmaier, N Amin, T Aspelund, T Bhangale, G Boucher, DI Chasman, C Chen, L Coin, MN Cooper, AL Dixon, Q Gibson, E Grundberg, K Hao, M Juhani Junttila, LM Kaplan, J Kettunen, IR König, T Kwan, RW Lawrence, DF Levinson, M Lorentzon, B McKnight, AP Morris, M Müller, J Suh Ngwa, S Purcell, S Rafelt, RM Salem, E Salvi, S Sanna, J Shi, U Sovio, JR Thompson, MC Turchin, L Vandenput, DJ Verlaan, V Vitart, CC White, A Ziegler, P Almgren, AJ Balmforth, H Campbell, L Citterio, A De Grandi, A Dominiczak, J Duan, P Elliott, R Elosua, JG Eriksson, NB Freimer, EJ Geus, N Glorioso, S Haiqing, AL Hartikainen, AS Havulinna, AA Hicks, J Hui, W Igl, T Illig, A Jula, E Kajantie, TO Kilpeläinen, M Koiranen, I Kolcic, S Koskinen, P Kovacs, J Laitinen, J Liu, ML Lokki, A Marusic, A Maschio, T Meitinger, A Mulas, G Paré, AN Parker, JF Peden, A Petersmann, I Pichler, KH Pietiläinen, A Pouta, M Ridderstråle, JI Rotter, JG Sambrook, AR Sanders, CO Schmidt, J Sinisalo, JH Smit, HM Stringham, G Bragi Walters, E Widen, SH Wild, G Willemsen, L Zagato, L Zgaga, P Zitting, H Alavere, M Farrall, WL McArdle, M Nelis, MJ Peters, S Ripatti, JB van Meurs, KK Aben, KG Ardlie, JS Beckmann, JP Beilby, RN Bergman, S Bergmann, FS Collins, D Cusi, M den Heijer, G Eiriksdottir, PV Gejman, AS Hall, A Hamsten, HV Huikuri, C Iribarren, M Kähönen, J Kaprio, S Kathiresan, L Kiemeney, T Kocher, LJ Launer, T Lehtimäki, O Melander, TH Mosley, AW Musk, MS Nieminen, CJ O'Donnell, C Ohlsson, B Oostra, LJ Palmer, O Raitakari, PM Ridker, JD Rioux, A Rissanen, C Rivolta, H Schunkert, AR Shuldiner, DS Siscovick, M Stumvoll, A Tönjes, J Tuomilehto, GJ van Ommen, J Viikari, AC Heath, NG Martin, GW Montgomery, MA Province, M Kayser, AM Arnold, LD Atwood, E Boerwinkle, SJ Chanock, P Deloukas, C Gieger, H Grönberg, P Hall, AT Hattersley, C Hengstenberg, W Hoffman, GM Lathrop, V Salomaa, S Schreiber, M Uda, D Waterworth, AF Wright, TL Assimes, I Barroso, A Hofman, KL Mohlke, DI Boomsma, MJ Caulfield, LA Cupples, J Erdmann, CS Fox, V Gudnason, U Gyllensten, TB Harris, RB Hayes, MR Jarvelin, V Mooser, PB Munroe, WH Ouwehand, BW Penninx, PP Pramstaller, T Quertermous, I Rudan, NJ Samani, TD Spector, H Völzke, H Watkins, JF Wilson, LC Groop, T Haritunians, FB Hu, RC Kaplan, A Metspalu, KE North, D Schlessinger, NJ Wareham, DJ Hunter, JR O'Connell, DP Strachan, HE Wichmann, IB Borecki, CM van Duijn, EE Schadt, U Thorsteinsdottir, L Peltonen, AG Uitterlinden, PM Visscher, N Chatterjee, RJ Loos, M Boehnke, MI McCarthy, E Ingelsson, CM Lindgren, GR Abecasis, K Stefansson, TM Frayling, JN Hirschhorn
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Waist-to-hip ratio adjusted for body mass index. The EFO term waist-hip ratio, body mass index was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
D Shungin, TW Winkler, DC Croteau-Chonka, T Ferreira, AE Locke, R Mägi, RJ Strawbridge, TH Pers, K Fischer, AE Justice, T Workalemahu, JM Wu, ML Buchkovich, NL Heard-Costa, TS Roman, AW Drong, C Song, S Gustafsson, FR Day, T Esko, T Fall, Z Kutalik, J Luan, JC Randall, A Scherag, S Vedantam, AR Wood, J Chen, R Fehrmann, J Karjalainen, B Kahali, CT Liu, EM Schmidt, D Absher, N Amin, D Anderson, M Beekman, JL Bragg-Gresham, S Buyske, A Demirkan, GB Ehret, MF Feitosa, A Goel, AU Jackson, T Johnson, ME Kleber, K Kristiansson, M Mangino, I Mateo Leach, C Medina-Gomez, CD Palmer, D Pasko, S Pechlivanis, MJ Peters, I Prokopenko, A Stančáková, Y Ju Sung, T Tanaka, A Teumer, JV Van Vliet-Ostaptchouk, L Yengo, W Zhang, E Albrecht, J Ärnlöv, GM Arscott, S Bandinelli, A Barrett, C Bellis, AJ Bennett, C Berne, M Blüher, S Böhringer, F Bonnet, Y Böttcher, M Bruinenberg, DB Carba, IH Caspersen, R Clarke, EW Daw, J Deelen, E Deelman, G Delgado, AS Doney, N Eklund, MR Erdos, K Estrada, E Eury, N Friedrich, ME Garcia, V Giedraitis, B Gigante, AS Go, A Golay, H Grallert, TB Grammer, J Gräßler, J Grewal, CJ Groves, T Haller, G Hallmans, CA Hartman, M Hassinen, C Hayward, K Heikkilä, KH Herzig, Q Helmer, HL Hillege, O Holmen, SC Hunt, A Isaacs, T Ittermann, AL James, I Johansson, T Juliusdottir, IP Kalafati, L Kinnunen, W Koenig, IK Kooner, W Kratzer, C Lamina, K Leander, NR Lee, P Lichtner, L Lind, J Lindström, S Lobbens, M Lorentzon, F Mach, PK Magnusson, A Mahajan, WL McArdle, C Menni, S Merger, E Mihailov, L Milani, R Mills, A Moayyeri, KL Monda, SP Mooijaart, TW Mühleisen, A Mulas, G Müller, M Müller-Nurasyid, R Nagaraja, MA Nalls, N Narisu, N Glorioso, IM Nolte, M Olden, NW Rayner, F Renstrom, JS Ried, NR Robertson, LM Rose, S Sanna, H Scharnagl, S Scholtens, B Sennblad, T Seufferlein, CM Sitlani, A Vernon Smith, K Stirrups, HM Stringham, J Sundström, MA Swertz, AJ Swift, AC Syvänen, BO Tayo, B Thorand, G Thorleifsson, A Tomaschitz, C Troffa, FV van Oort, N Verweij, JM Vonk, LL Waite, R Wennauer, T Wilsgaard, MK Wojczynski, A Wong, Q Zhang, J Hua Zhao, EP Brennan, M Choi, P Eriksson, L Folkersen, A Franco-Cereceda, AG Gharavi, ÅK Hedman, MF Hivert, J Huang, S Kanoni, F Karpe, S Keildson, K Kiryluk, L Liang, RP Lifton, B Ma, AJ McKnight, R McPherson, A Metspalu, JL Min, MF Moffatt, GW Montgomery, JM Murabito, G Nicholson, DR Nyholt, C Olsson, JR Perry, E Reinmaa, RM Salem, N Sandholm, EE Schadt, RA Scott, L Stolk, EE Vallejo, HJ Westra, KT Zondervan, P Amouyel, D Arveiler, SJ Bakker, J Beilby, RN Bergman, J Blangero, MJ Brown, M Burnier, H Campbell, A Chakravarti, PS Chines, S Claudi-Boehm, FS Collins, DC Crawford, J Danesh, U de Faire, EJ de Geus, M Dörr, R Erbel, JG Eriksson, M Farrall, E Ferrannini, J Ferrières, NG Forouhi, T Forrester, OH Franco, RT Gansevoort, C Gieger, V Gudnason, CA Haiman, TB Harris, AT Hattersley, M Heliövaara, AA Hicks, AD Hingorani, W Hoffmann, A Hofman, G Homuth, SE Humphries, E Hyppönen, T Illig, MR Jarvelin, B Johansen, P Jousilahti, AM Jula, J Kaprio, F Kee, SM Keinanen-Kiukaanniemi, JS Kooner, C Kooperberg, P Kovacs, AT Kraja, M Kumari, K Kuulasmaa, J Kuusisto, TA Lakka, C Langenberg, L Le Marchand, T Lehtimäki, V Lyssenko, S Männistö, A Marette, TC Matise, CA McKenzie, B McKnight, AW Musk, S Möhlenkamp, AD Morris, M Nelis, C Ohlsson, AJ Oldehinkel, KK Ong, LJ Palmer, BW Penninx, A Peters, PP Pramstaller, OT Raitakari, T Rankinen, DC Rao, TK Rice, PM Ridker, MD Ritchie, I Rudan, V Salomaa, NJ Samani, J Saramies, MA Sarzynski, PE Schwarz, AR Shuldiner, JA Staessen, V Steinthorsdottir, RP Stolk, K Strauch, A Tönjes, A Tremblay, E Tremoli, MC Vohl, U Völker, P Vollenweider, JF Wilson, JC Witteman, LS Adair, M Bochud, BO Boehm, SR Bornstein, C Bouchard, S Cauchi, MJ Caulfield, JC Chambers, DI Chasman, RS Cooper, G Dedoussis, L Ferrucci, P Froguel, HJ Grabe, A Hamsten, J Hui, K Hveem, KH Jöckel, M Kivimaki, D Kuh, M Laakso, Y Liu, W März, PB Munroe, I Njølstad, BA Oostra, CN Palmer, NL Pedersen, M Perola, L Pérusse, U Peters, C Power, T Quertermous, R Rauramaa, F Rivadeneira, TE Saaristo, D Saleheen, J Sinisalo, PE Slagboom, H Snieder, TD Spector, U Thorsteinsdottir, M Stumvoll, J Tuomilehto, AG Uitterlinden, M Uusitupa, P van der Harst, G Veronesi, M Walker, NJ Wareham, H Watkins, HE Wichmann, GR Abecasis, TL Assimes, SI Berndt, M Boehnke, IB Borecki, P Deloukas, L Franke, TM Frayling, LC Groop, DJ Hunter, RC Kaplan, JR O'Connell, L Qi, D Schlessinger, DP Strachan, K Stefansson, CM van Duijn, CJ Willer, PM Visscher, J Yang, JN Hirschhorn, MC Zillikens, MI McCarthy, EK Speliotes, KE North, CS Fox, I Barroso, PW Franks, E Ingelsson, IM Heid, RJ Loos, LA Cupples, AP Morris, CM Lindgren, KL Mohlke
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Type 2 diabetes. The EFO term type II diabetes mellitus was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
A Mahajan, MJ Go, W Zhang, JE Below, KJ Gaulton, T Ferreira, M Horikoshi, AD Johnson, MC Ng, I Prokopenko, D Saleheen, X Wang, E Zeggini, GR Abecasis, LS Adair, P Almgren, M Atalay, T Aung, D Baldassarre, B Balkau, Y Bao, AH Barnett, I Barroso, A Basit, LF Been, J Beilby, GI Bell, R Benediktsson, RN Bergman, BO Boehm, E Boerwinkle, LL Bonnycastle, N Burtt, Q Cai, H Campbell, J Carey, S Cauchi, M Caulfield, JC Chan, LC Chang, TJ Chang, YC Chang, G Charpentier, CH Chen, H Chen, YT Chen, KS Chia, M Chidambaram, PS Chines, NH Cho, YM Cho, LM Chuang, FS Collins, MC Cornelis, DJ Couper, AT Crenshaw, RM van Dam, J Danesh, D Das, U de Faire, G Dedoussis, P Deloukas, AS Dimas, C Dina, AS Doney, PJ Donnelly, M Dorkhan, C van Duijn, J Dupuis, S Edkins, P Elliott, V Emilsson, R Erbel, JG Eriksson, J Escobedo, T Esko, E Eury, JC Florez, P Fontanillas, NG Forouhi, T Forsen, C Fox, RM Fraser, TM Frayling, P Froguel, P Frossard, Y Gao, K Gertow, C Gieger, B Gigante, H Grallert, GB Grant, LC Grrop, CJ Groves, E Grundberg, C Guiducci, A Hamsten, BG Han, K Hara, N Hassanali, AT Hattersley, C Hayward, AK Hedman, C Herder, A Hofman, OL Holmen, K Hovingh, AB Hreidarsson, C Hu, FB Hu, J Hui, SE Humphries, SE Hunt, DJ Hunter, K Hveem, ZI Hydrie, H Ikegami, T Illig, E Ingelsson, M Islam, B Isomaa, AU Jackson, T Jafar, A James, W Jia, KH Jöckel, A Jonsson, JB Jowett, T Kadowaki, HM Kang, S Kanoni, WH Kao, S Kathiresan, N Kato, P Katulanda, KM Keinanen-Kiukaanniemi, AM Kelly, H Khan, KT Khaw, CC Khor, HL Kim, S Kim, YJ Kim, L Kinnunen, N Klopp, A Kong, E Korpi-Hyövälti, S Kowlessur, P Kraft, J Kravic, MM Kristensen, S Krithika, A Kumar, J Kumate, J Kuusisto, SH Kwak, M Laakso, V Lagou, TA Lakka, C Langenberg, C Langford, R Lawrence, K Leander, JM Lee, NR Lee, M Li, X Li, Y Li, J Liang, S Liju, WY Lim, L Lind, CM Lindgren, E Lindholm, CT Liu, JJ Liu, S Lobbens, J Long, RJ Loos, W Lu, J Luan, V Lyssenko, RC Ma, S Maeda, R Mägi, S Männisto, DR Matthews, JB Meigs, O Melander, A Metspalu, J Meyer, G Mirza, E Mihailov, S Moebus, V Mohan, KL Mohlke, AD Morris, TW Mühleisen, M Müller-Nurasyid, B Musk, J Nakamura, E Nakashima, P Navarro, PK Ng, AC Nica, PM Nilsson, I Njølstad, MM Nöthen, K Ohnaka, TH Ong, KR Owen, CN Palmer, JS Pankow, KS Park, M Parkin, S Pechlivanis, NL Pedersen, L Peltonen, JR Perry, A Peters, JM Pinidiyapathirage, CG Platou, S Potter, JF Price, L Qi, V Radha, L Rallidis, A Rasheed, W Rathman, R Rauramaa, S Raychaudhuri, NW Rayner, SD Rees, E Rehnberg, S Ripatti, N Robertson, M Roden, EJ Rossin, I Rudan, D Rybin, TE Saaristo, V Salomaa, J Saltevo, M Samuel, DK Sanghera, J Saramies, J Scott, LJ Scott, RA Scott, AV Segrè, J Sehmi, B Sennblad, N Shah, S Shah, AS Shera, XO Shu, AR Shuldiner, G Sigurđsson, E Sijbrands, A Silveira, X Sim, S Sivapalaratnam, KS Small, WY So, A Stančáková, K Stefansson, G Steinbach, V Steinthorsdottir, K Stirrups, RJ Strawbridge, HM Stringham, Q Sun, C Suo, AC Syvänen, R Takayanagi, F Takeuchi, WT Tay, TM Teslovich, B Thorand, G Thorleifsson, U Thorsteinsdottir, E Tikkanen, J Trakalo, E Tremoli, MD Trip, FJ Tsai, T Tuomi, J Tuomilehto, AG Uitterlinden, A Valladares-Salgado, S Vedantam, F Veglia, BF Voight, C Wang, NJ Wareham, R Wennauer, AR Wickremasinghe, T Wilsgaard, JF Wilson, S Wiltshire, W Winckler, TY Wong, AR Wood, JY Wu, Y Wu, K Yamamoto, T Yamauchi, M Yang, L Yengo, M Yokota, R Young, D Zabaneh, F Zhang, R Zhang, W Zheng, PZ Zimmet, D Altshuler, DW Bowden, YS Cho, NJ Cox, M Cruz, CL Hanis, J Kooner, JY Lee, M Seielstad, YY Teo, M Boehnke, EJ Parra, JC Chambers, ES Tai, MI McCarthy, AP Morris
GWAS: anthropometric measurement, waist-hip ratio, sexual dimorphism
Description:
List of positional candidate genes after correcting for multiple testing and controlling the false discovery rate from genome wide association studies (GWAS) retrieved from the NHGRI-EBI Catalog of published genome-wide association studies (http://www.ebi.ac.uk/gwas/). The disease/trait examined in this study, as reported by the authors, was Sexual dimorphism in anthropometric traits. The EFO term anthropometric measurement, waist-hip ratio, sexual dimorphism was annotated to this set after curation by NHGRI-EBI. Intergenic SNPS were mapped to both the upstream and downstream gene. P-value uploaded. This gene set was generated using gwas2gs v. 0.1.8 and the GWAS Catalog v. 1.0.1.
Authors:
JC Randall, TW Winkler, Z Kutalik, SI Berndt, AU Jackson, KL Monda, TO Kilpeläinen, T Esko, R Mägi, S Li, T Workalemahu, MF Feitosa, DC Croteau-Chonka, FR Day, T Fall, T Ferreira, S Gustafsson, AE Locke, I Mathieson, A Scherag, S Vedantam, AR Wood, L Liang, V Steinthorsdottir, G Thorleifsson, ET Dermitzakis, AS Dimas, F Karpe, JL Min, G Nicholson, DJ Clegg, T Person, JP Krohn, S Bauer, C Buechler, K Eisinger, A Bonnefond, P Froguel, JJ Hottenga, I Prokopenko, LL Waite, TB Harris, AV Smith, AR Shuldiner, WL McArdle, MJ Caulfield, PB Munroe, H Grönberg, YD Chen, G Li, JS Beckmann, T Johnson, U Thorsteinsdottir, M Teder-Laving, KT Khaw, NJ Wareham, JH Zhao, N Amin, BA Oostra, AT Kraja, MA Province, LA Cupples, NL Heard-Costa, J Kaprio, S Ripatti, I Surakka, FS Collins, J Saramies, J Tuomilehto, A Jula, V Salomaa, J Erdmann, C Hengstenberg, C Loley, H Schunkert, C Lamina, HE Wichmann, E Albrecht, C Gieger, AA Hicks, A Johansson, PP Pramstaller, S Kathiresan, EK Speliotes, B Penninx, AL Hartikainen, MR Jarvelin, U Gyllensten, DI Boomsma, H Campbell, JF Wilson, SJ Chanock, M Farrall, A Goel, C Medina-Gomez, F Rivadeneira, K Estrada, AG Uitterlinden, A Hofman, MC Zillikens, M den Heijer, LA Kiemeney, A Maschio, P Hall, J Tyrer, A Teumer, H Völzke, P Kovacs, A Tönjes, M Mangino, TD Spector, C Hayward, I Rudan, AS Hall, NJ Samani, AP Attwood, JG Sambrook, J Hung, LJ Palmer, ML Lokki, J Sinisalo, G Boucher, H Huikuri, M Lorentzon, C Ohlsson, N Eklund, JG Eriksson, C Barlassina, C Rivolta, IM Nolte, H Snieder, MM Van der Klauw, JV Van Vliet-Ostaptchouk, PV Gejman, J Shi, KB Jacobs, Z Wang, SJ Bakker, I Mateo Leach, G Navis, P van der Harst, NG Martin, SE Medland, GW Montgomery, J Yang, DI Chasman, PM Ridker, LM Rose, T Lehtimäki, O Raitakari, D Absher, C Iribarren, H Basart, KG Hovingh, E Hyppönen, C Power, D Anderson, JP Beilby, J Hui, J Jolley, H Sager, SR Bornstein, PE Schwarz, K Kristiansson, M Perola, J Lindström, AJ Swift, M Uusitupa, M Atalay, TA Lakka, R Rauramaa, JL Bolton, G Fowkes, RM Fraser, JF Price, K Fischer, K Krjutå Kov, A Metspalu, E Mihailov, C Langenberg, J Luan, KK Ong, PS Chines, SM Keinanen-Kiukaanniemi, TE Saaristo, S Edkins, PW Franks, G Hallmans, D Shungin, AD Morris, CN Palmer, R Erbel, S Moebus, MM Nöthen, S Pechlivanis, K Hveem, N Narisu, A Hamsten, SE Humphries, RJ Strawbridge, E Tremoli, H Grallert, B Thorand, T Illig, W Koenig, M Müller-Nurasyid, A Peters, BO Boehm, ME Kleber, W März, BR Winkelmann, J Kuusisto, M Laakso, D Arveiler, G Cesana, K Kuulasmaa, J Virtamo, JW Yarnell, D Kuh, A Wong, L Lind, U de Faire, B Gigante, PK Magnusson, NL Pedersen, G Dedoussis, M Dimitriou, G Kolovou, S Kanoni, K Stirrups, LL Bonnycastle, I Njølstad, T Wilsgaard, A Ganna, E Rehnberg, A Hingorani, M Kivimaki, M Kumari, TL Assimes, I Barroso, M Boehnke, IB Borecki, P Deloukas, CS Fox, T Frayling, LC Groop, T Haritunians, D Hunter, E Ingelsson, R Kaplan, KL Mohlke, JR O'Connell, D Schlessinger, DP Strachan, K Stefansson, CM van Duijn, GR Abecasis, MI McCarthy, JN Hirschhorn, L Qi, RJ Loos, CM Lindgren, KE North, IM Heid
This gene set describes genes that are up-regulated by the host transcriptional response to seasonal influenza A virus (IAV) infection in human adenocarcinomic alveolar basal epithelial (A549) cells. These data were used for comparison with SARS-CoV-2 infection. COVID-19 is the disease caused by SARS-CoV-2 virus. We define up-regulated as those genes that show a (log 2 fold change) of >= 1.5. These data are from the supplementary materials associated with a publication that, as of 5/5/2020, has not yet been peer-reviewed: https://www.biorxiv.org/content/10.1101/2020.03.24.004655v1
RNA sequencing of a limited number of archived patients' specimens with extended opioid exposure or non-opioid exposure was performed. Immune infiltration and changes in the microenvironment were evaluated using CIBERSORT.
Authors:
Mamatha Garige, Sarah Poncet, Alexis Norris, Chao-Kai Chou, Wells W Wu, Rong-Fong Shen, Jacob W Greenberg, Louis Spencer Krane, Carole Sourbier
The dataset used in this study (Bulk RNA-Seq) was previously published and can be found at NCBI GEO (GSE182321), this analysis was conducted by GEO2R to compare control and OUD samples, only top differentially expressed genes are reported. To understand mechanisms and identify potential targets for intervention in the current crisis of opioid use disorder (OUD), postmortem brains represent an under-utilized resource. To refine previously reported gene signatures of neurobiological alterations in OUD from the dorsolateral prefrontal cortex (Brodmann Area 9, BA9), we explored the role of microRNAs (miRNA) as powerful epigenetic regulators of gene function.
The dataset used in this study (Bulk RNA-Seq) was previously published and can be found at NCBI GEO (GSE182321), this analysis was conducted by GEO2R to compare control and OUD samples, only top differentially expressed genes are reported. To understand mechanisms and identify potential targets for intervention in the current crisis of opioid use disorder (OUD), postmortem brains represent an under-utilized resource. To refine previously reported gene signatures of neurobiological alterations in OUD from the dorsolateral prefrontal cortex (Brodmann Area 9, BA9), we explored the role of microRNAs (miRNA) as powerful epigenetic regulators of gene function.
Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use disorder. Transcriptomic profile of 20 control subjects and 20 OUD subjects in brain region DLPFC and NAC. Analyzed using GEO2R (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174409) separately for each brain region, comparing OUD and control samples.
Authors:
Xiangning Xue, Wei Zong, Jill R Glausier, Sam-Moon Kim, Micah A Shelton, BaDoi N Phan, Chaitanya Srinivasan, Andreas R Pfenning, George C Tseng, David A Lewis, Marianne L Seney, Ryan W Logan
Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use disorder. Transcriptomic profile of 20 control subjects and 20 OUD subjects in brain region DLPFC and NAC. Analyzed using GEO2R (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE174409) separately for each brain region, comparing OUD and control samples.
Authors:
Xiangning Xue, Wei Zong, Jill R Glausier, Sam-Moon Kim, Micah A Shelton, BaDoi N Phan, Chaitanya Srinivasan, Andreas R Pfenning, George C Tseng, David A Lewis, Marianne L Seney, Ryan W Logan
Postmortem tissue samples of the dorsolateral prefrontal cortex (DLPFC) from 153 deceased individuals (Mage = 35.4; 62% male; 77% European ancestry). Study groups included 72 brain samples from individuals who died of acute opioid intoxication, 53 psychiatric controls, and 28 normal controls. Whole transcriptome RNA-sequencing was used to generate exon counts, and differential expression was tested using limma-voom. Analyses were adjusted for relevant sociodemographic characteristics, technical covariates, and cryptic relatedness using quality surrogate variables. Weighted correlation network analysis and gene set enrichment analyses also were conducted.
Authors:
David W Sosnowski, Andrew E Jaffe, Ran Tao, Amy Deep-Soboslay, Chang Shu, Sarven Sabunciyan, Joel E Kleinman, Thomas M Hyde, Brion S Maher
Differential gene expression between CS15 and CS22 - Log2FC
Description:
Human craniofacial tissues were collected from the Joint MRC/Wellcome Trust Human Developmental Biology (HDBR). Donations of tissue to HDBR are made under-informed ethical consent with Research Tissue Bank ethical approval by women undergoing termination of pregnancy. Gene expression profiles were generated from multiple biological replicates of primary craniofacial (CF) tissue from Carnegie Stages (CS) of the embryonic period, CS13, CS14, CS17, CS17, and CS22. Here the differential expression comparison between CS15 and CS22 is shown. Gene expressions values with log to the base 2, FC are presented with P-Adj <0.05. UBERON:0015789, cranial or facial muscle.
Authors:
Tara N Yankee, Sungryong Oh, Emma Wentworth Winchester, Andrea Wilderman, Kelsey Robinson, Tia Gordon, Jill A Rosenfeld, Jennifer VanOudenhove, Daryl A Scott, Elizabeth J Leslie, Justin Cotney
Differential gene expression between CS15 and CS22 - Adj-P value
Description:
Human craniofacial tissues were collected from the Joint MRC/Wellcome Trust Human Developmental Biology (HDBR). Donations of tissue to HDBR are made under-informed ethical consent with Research Tissue Bank ethical approval by women undergoing termination of pregnancy. Gene expression profiles were generated from multiple biological replicates of primary craniofacial (CF) tissue from Carnegie Stages (CS) of the embryonic period, CS13, CS14, CS17, CS17 and CS22. Here the differential expression comparison between CS15 and CS22 is shown. Gene expressions values, Ensembl Gene ids and the corresponding Adjusted P value are presented. UBERON:0015789, cranial or facial muscle.
Authors:
Tara N Yankee, Sungryong Oh, Emma Wentworth Winchester, Andrea Wilderman, Kelsey Robinson, Tia Gordon, Jill A Rosenfeld, Jennifer VanOudenhove, Daryl A Scott, Elizabeth J Leslie, Justin Cotney
Differential gene expression between CS13 and CS22 - Log2FC
Description:
Human craniofacial tissues were collected from the Joint MRC/Wellcome Trust Human Developmental Biology (HDBR). Donations of tissue to HDBR are made under-informed ethical consent with Research Tissue Bank ethical approval by women undergoing termination of pregnancy. Gene expression profiles were generated from multiple biological replicates of primary craniofacial (CF) tissue from Carnegie Stages (CS) of the embryonic period, CS13, CS14, CS17, CS17, and CS22. Here the differential expression comparison between CS13 and CS22 is shown. Gene expressions values with log to the base 2, FC are presented with P-Adj <0.05. UBERON:0015789, cranial or facial muscle.
Authors:
Tara N Yankee, Sungryong Oh, Emma Wentworth Winchester, Andrea Wilderman, Kelsey Robinson, Tia Gordon, Jill A Rosenfeld, Jennifer VanOudenhove, Daryl A Scott, Elizabeth J Leslie, Justin Cotney
Differential gene expression between CS13 and CS22 - Adj-P value
Description:
Human craniofacial tissues were collected from the Joint MRC/Wellcome Trust Human Developmental Biology (HDBR). Donations of tissue to HDBR are made under-informed ethical consent with Research Tissue Bank ethical approval by women undergoing termination of pregnancy. Gene expression profiles were generated from multiple biological replicates of primary craniofacial (CF) tissue from Carnegie Stages (CS) of the embryonic period, CS13, CS14, CS17, CS17 and CS22. Here the differential expression comparison between CS13 and CS22 is shown. Gene expressions values, Ensembl Gene ids and the corresponding Adjusted P value are presented. UBERON:0015789, cranial or facial muscle.
Authors:
Tara N Yankee, Sungryong Oh, Emma Wentworth Winchester, Andrea Wilderman, Kelsey Robinson, Tia Gordon, Jill A Rosenfeld, Jennifer VanOudenhove, Daryl A Scott, Elizabeth J Leslie, Justin Cotney
Differential gene expression between CS17 and CS22 - Log2FC
Description:
Human craniofacial tissues were collected from the Joint MRC/Wellcome Trust Human Developmental Biology (HDBR). Donations of tissue to HDBR are made under-informed ethical consent with Research Tissue Bank ethical approval by women undergoing termination of pregnancy. Gene expression profiles were generated from multiple biological replicates of primary craniofacial (CF) tissue from Carnegie Stages (CS) of the embryonic period, CS13, CS14, CS17, CS17, and CS22. Here the differential expression comparison between CS17 and CS22 is shown. Gene expressions values with log to the base 2, FC are presented with P-Adj <0.05. UBERON:0015789, cranial or facial muscle.
Authors:
Tara N Yankee, Sungryong Oh, Emma Wentworth Winchester, Andrea Wilderman, Kelsey Robinson, Tia Gordon, Jill A Rosenfeld, Jennifer VanOudenhove, Daryl A Scott, Elizabeth J Leslie, Justin Cotney
Differential gene expression between CS14 and CS22 - Adj-P value
Description:
Human craniofacial tissues were collected from the Joint MRC/Wellcome Trust Human Developmental Biology (HDBR). Donations of tissue to HDBR are made under-informed ethical consent with Research Tissue Bank ethical approval by women undergoing termination of pregnancy. Gene expression profiles were generated from multiple biological replicates of primary craniofacial (CF) tissue from Carnegie Stages (CS) of the embryonic period, CS13, CS14, CS17, CS17 and CS22. Here the differential expression comparison between CS14 and CS22 is shown. Gene expressions values, Ensembl Gene ids and the corresponding Adjusted P value are presented. UBERON:0015789, cranial or facial muscle.
Authors:
Tara N Yankee, Sungryong Oh, Emma Wentworth Winchester, Andrea Wilderman, Kelsey Robinson, Tia Gordon, Jill A Rosenfeld, Jennifer VanOudenhove, Daryl A Scott, Elizabeth J Leslie, Justin Cotney
Differential gene expression between CS14 and CS22 - Log2FC
Description:
Human craniofacial tissues were collected from the Joint MRC/Wellcome Trust Human Developmental Biology (HDBR). Donations of tissue to HDBR are made under-informed ethical consent with Research Tissue Bank ethical approval by women undergoing termination of pregnancy. Gene expression profiles were generated from multiple biological replicates of primary craniofacial (CF) tissue from Carnegie Stages (CS) of the embryonic period, CS13, CS14, CS17, CS17, and CS22. Here the differential expression comparison between CS14 and CS22 is shown. Gene expressions values with log to the base 2, FC are presented with P-Adj <0.05. UBERON:0015789, cranial or facial muscle.
Authors:
Tara N Yankee, Sungryong Oh, Emma Wentworth Winchester, Andrea Wilderman, Kelsey Robinson, Tia Gordon, Jill A Rosenfeld, Jennifer VanOudenhove, Daryl A Scott, Elizabeth J Leslie, Justin Cotney
Differential gene expression between CS14 and CS22 - Adj-P value
Description:
Human craniofacial tissues were collected from the Joint MRC/Wellcome Trust Human Developmental Biology (HDBR). Donations of tissue to HDBR are made under-informed ethical consent with Research Tissue Bank ethical approval by women undergoing termination of pregnancy. Gene expression profiles were generated from multiple biological replicates of primary craniofacial (CF) tissue from Carnegie Stages (CS) of the embryonic period, CS13, CS14, CS17, CS17 and CS22. Here the differential expression comparison between CS14 and CS22 is shown. Gene expressions values, Ensembl Gene ids and the corresponding Adjusted P value are presented. UBERON:0015789, cranial or facial muscle.
Authors:
Tara N Yankee, Sungryong Oh, Emma Wentworth Winchester, Andrea Wilderman, Kelsey Robinson, Tia Gordon, Jill A Rosenfeld, Jennifer VanOudenhove, Daryl A Scott, Elizabeth J Leslie, Justin Cotney
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