QTL for ethanol withdrawal on Chr12 at D12Ncvs38 (14.25 Mbp , Build 37)
Description:
ethanol withdrawal spans 0.00 - 39.25 Mbp (NCBI Build 37) on Chr12. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
QTL associated with antibody mediated myocarditis. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (111536237)
QTL associated with acute functional tolerance to ethanol QTL 1. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (114657953)
Authors:
Bennett B, Downing C, Carosone-Link P, Ponicsan H, Ruf C, Johnson TE
QTL associated with B.burgdorferi-associated arthritis 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (111536237)
Authors:
Ma Y, Miller JC, Crandall H, Larsen ET, Dunn DM, Weiss RB, Subramanian M, Weis JH, Zachary JF, Teuscher C, Weis JJ
QTL associated with circulating hormone level QTL 17. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (106324825)
QTL associated with Crh transcript abundance QTL 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (112417841)
QTL associated with delta power in slow-wave sleep 2. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (112417841)
QTL associated with wound healing/regeneration 5. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (108210982)
Authors:
Heber-Katz E, Leferovich JM, Bedelbaeva K, Gourevitch D
QTL associated with prion disease incubation time 4. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (106580305)
Authors:
Lloyd SE, Onwuazor ON, Beck JA, Mallinson G, Farrall M, Targonski P, Collinge J, Fisher EM
QTL associated with susceptibility to lung cancer 12. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (115134928)
QTL associated with thymic lymphoma suppressor region 6. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (109695607)
Authors:
Matsumoto Y, Kosugi S, Shinbo T, Chou D, Ohashi M, Wakabayashi Y, Sakai K, Okumoto M, Mori N, Aizawa S, Niwa O, Kominami R
QTL associated with vertebral trabecular bone trait 14. This interval was obtained by using a fixed interval width of 25 Mbp around the peak marker (111207873)
Authors:
Bouxsein ML, Uchiyama T, Rosen CJ, Shultz KL, Donahue LR, Turner CH, Sen S, Churchill GA, Mller R, Beamer WG
Differential gene expression in nucleus accumbens somatostatin interneurons_cocaine_mice_pvalue
Description:
To characterize transcriptional alterations that cocaine induces in these cells, we perform cell type-specific RNA-sequencing on FACS-isolated nuclei of somatostatin interneurons and identified 1100 DETs enriched for processes related to neural plasticity. To profile the entire (non poly-A selected) transcriptome of NAc somatostatin interneurons, we generated a transgenic reporter line (SST-TLG498 mice) to label the nuclei of these cells with a modified form of EGFP that is retained in the nuclear membrane (EGFP-F)22, enabling their isolation from NAc dissections using FACS. We succeeded in FACS-isolating nuclei suitable for RNA-sequencing from individual SST-TLG498 mice. We proceeded with differential expression analysis of the RNA-sequencing data to identify differentially expressed transcripts (DETs) in NAc somatostatin interneurons in response to repeated cocaine exposure: 778 transcripts were upregulated by cocaine and 322 were downregulated.
Authors:
Efrain A Ribeiro, Marine Salery, Joseph R Scarpa, Erin S Calipari, Peter J Hamilton, Stacy M Ku, Hope Kronman, Immanuel Purushothaman, Barbara Juarez, Mitra Heshmati, Marie Doyle, Casey Lardner, Dominicka Burek, Ana Strat, Stephen Pirpinias, Ezekiell Mouzon, Ming-Hu Han, Rachael L Neve, Rosemary C Bagot, Andrew Kasarskis, Ja Wook Koo, Eric J Nestler
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