QTL for high-dose ethanol actions on Chr9 at D9Mit42 (21.79 Mbp , Build 37)
Description:
high-dose ethanol actions spans 0.00 - 46.79 Mbp (NCBI Build 37) on Chr9. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Erwin VG, Markel PD, Johnson TE, Gehle VM, Jones BC
alcohol response 4 (a.k.a. high-dose ethanol actions) is associated with neurotensin immunoreactivity and sleep time after alcohol administration mapped to 55 cM on mouse Chromosome 9 near D9Mit12 (P=0.0006). This locus is named Alcrsp4 (alcohol response 4). Potential candidate genes found in this region are Chrna3 and Gnai2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Authors:
Erwin VG, Markel PD, Johnson TE, Gehle VM, Jones BC
Genes with particular expression in the Anterodorsal nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anterior olfactory nucleus, dorsal part. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Ventral part of the lateral geniculate complex. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Anteroventral nucleus of thalamus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Subgeniculate nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Bed nuclei of the stria terminalis, posterior division. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Bed nuclei of the stria terminalis, anterior division, oval nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Bed nuclei of the stria terminalis, anterior division, rhomboid nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Bed nuclei of the stria terminalis, posterior division, principal nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Bed nuclei of the stria terminalis, posterior division, interfascicular nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Bed nuclei of the stria terminalis, posterior division, strial extension. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Parasolitary nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Parabigeminal nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Fasciola cinerea. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Fastigial nucleus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Geniculate group, ventral thalamus. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Taenia tecta, dorsal part, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Taenia tecta, ventral part, layer 1. Data represent fold expression difference in structure versus grey matter average expression.
Genes with particular expression in the Taenia tecta, ventral part, layer 3. Data represent fold expression difference in structure versus grey matter average expression.
The novel object recognition test was performed on two independent cohorts of mice according to Nilsson et al. (2007). One cohort consisted of mice on the mixed C57BL/6J-129sv background, and the second cohort consisted of mice that had been backcrossed to the C57BL/6J strain for at least four generations. mRNA samples were collected from the hippocampus from FoxO6 mutant and wild-type siblings before (basal) or after novel object learning. 250 ng of total RNA was reverse-transcribed to cDNA, and cDNA was hybridized to the Mouse Gene 1.0 ST array (Affymetrix). 176 genes were up-regulated significantly following object learning in wild-type mice compared with FoxO6 mutant mice (P < 0.05 for interaction between the factors genotype and learning, two-way ANOVA; P < 0.05 for wild-type sibling basal vs. learning, one-way ANOVA).
Authors:
Salih DA, Rashid AJ, Colas D, de la Torre-Ubieta L, Zhu RP, Morgan AA, Santo EE, Ucar D, Devarajan K, Cole CJ, Madison DV, Shamloo M, Butte AJ, Bonni A, Josselyn SA, Brunet A
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