GeneSet Title
Tier II
Mouse
349 Genes
GS84114
LABEL: QTL for activity response to ethanol on Chr1 at NA (184.43 Mbp , Build 37)DESCRIPTION: activity response to ethanol spans 159.43 - 209.43 Mbp (NCBI Build 37) on Chr1. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Tier II
Mouse
516 Genes
GS84129
LABEL: QTL for activity response to ethanol on Chr2 at NA (80.10 Mbp , Build 37)DESCRIPTION: activity response to ethanol spans 55.10 - 105.10 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Tier II
Mouse
523 Genes
GS84133
LABEL: QTL for activity response to ethanol on Chr2 at NA (129.21 Mbp , Build 37)DESCRIPTION: activity response to ethanol spans 104.21 - 154.21 Mbp (NCBI Build 37) on Chr2. This interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Tier II
Mouse
754 Genes
GS84134
LABEL: QTL-Actre3-Mouse-Chr 2DESCRIPTION: QTLs associated with ethanol-induced activation of locomotor activity were provisionally mapped in 25 BXD (B = C57BL/6J, D = DBA/2J) recombinant inbred (RI) strains and confirmed in (DBA/2J x C57BL/6J)F2 intercross and HS (heterogeneous stock) animals. (HS strain was derived from outbreeding of C57BL/6J, DBA/2J, CBA/2J, C3H/HeJ, A/J, AKR/J, BALB/cJ, and LP/J inbred strains.) Progenitor strain DBA/2J exhibits increased activity with activity decrease over time following ethanol challenge whereas progenitor strain C57BL/6J exhibits low activity with activity increase over time. (DBA/2J x C57BL/6J)F1 hybrid animals resemble the DBA/2J response to ethanol challenge. QTLs affecting ethanol-induced locomotor activity were mapped and confirmed on mouse chromosome 2 at 62 cM-64 cM (Actre3, LOD = 9.8) 113125171-163125171, interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Tier V
Mouse
548 Genes
GS128620
LABEL: QTL-Actre4-Mouse-Chr 2DESCRIPTION: QTLs associated with ethanol-induced activation of locomotor activity were provisionally mapped in 25 BXD (B = C57BL/6J, D = DBA/2J) recombinant inbred (RI) strains and confirmed in (DBA/2J x C57BL/6J)F2 intercross and HS (heterogeneous stock) animals. (HS strain was derived from outbreeding of C57BL/6J, DBA/2J, CBA/2J, C3H/HeJ, A/J, AKR/J, BALB/cJ, and LP/J inbred strains.) Progenitor strain DBA/2J exhibits increased activity with activity decrease over time following ethanol challenge whereas progenitor strain C57BL/6J exhibits low activity with activity increase over time. (DBA/2J x C57BL/6J)F1 hybrid animals resemble the DBA/2J response to ethanol challenge. QTLs affecting ethanol-induced locomotor activity were mapped and confirmed on mouse Chromosome 1 at 64 cM - 66 cM (Actre4, LOD = 7) Candidate genes for Actre3 and Actre4 are Bdnf (62 cM). 93267803-143267803, interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
Tier V
Mouse
640 Genes
GS128621
LABEL: QTL-Actre2-Mouse-Chr 2DESCRIPTION: QTLs associated with ethanol-induced activation of locomotor activity were provisionally mapped in 25 BXD (B = C57BL/6J, D = DBA/2J) recombinant inbred (RI) strains and confirmed in (DBA/2J x C57BL/6J)F2 intercross and HS (heterogeneous stock) animals. (HS strain was derived from outbreeding of C57BL/6J, DBA/2J, CBA/2J, C3H/HeJ, A/J, AKR/J, BALB/cJ, and LP/J inbred strains.) Progenitor strain DBA/2J exhibits increased activity with activity decrease over time following ethanol challenge whereas progenitor strain C57BL/6J exhibits low activity with activity increase over time. (DBA/2J x C57BL/6J)F1 hybrid animals resemble the DBA/2J response to ethanol challenge. QTLs affecting ethanol-induced locomotor activity were mapped and confirmed on mouse chromosome 2 at 62 cM-64 cM (Actre3, LOD = 9.8) 89118625-139118625, interval was obtained by using an interval width of 25 Mbp around the peak marker (Build 37, MGI, http://informatics.jax.org).
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