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			GeneSet Title
Tier IV	Mouse	13178 Genes	GS408388 Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after acute cocaine treatment_logFC
			LABEL: Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after acute cocaine treatment_logFC DESCRIPTION: To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Tier IV	Mouse	13178 Genes	GS408389 Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after acute cocaine treatment_FDR
			LABEL: Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after acute cocaine treatment_FDR DESCRIPTION: To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Tier IV	Mouse	26355 Genes	GS408390 Differential gene expression in the prelimbic cortex of WT vs SERT Met172 mice after acute cocaine treatment_logFC
			LABEL: Differential gene expression in the prelimbic cortex of WT vs SERT Met172 mice after acute cocaine treatment_logFC DESCRIPTION: To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Tier IV	Mouse	13178 Genes	GS408391 Differential gene expression in the prelimbic cortex of WT vs SERT Met172 mice after acute cocaine treatment_FDR
			LABEL: Differential gene expression in the prelimbic cortex of WT vs SERT Met172 mice after acute cocaine treatment_FDR DESCRIPTION: To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Tier IV	Mouse	13178 Genes	GS408392 Differential gene expression in the prelimbic cortex of WT vs SERT Met172 mice after acute cocaine treatment_logFC
			LABEL: Differential gene expression in the prelimbic cortex of WT vs SERT Met172 mice after acute cocaine treatment_logFC DESCRIPTION: To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Tier IV	Mouse	1 Genes	GS408393 Differential gene expression in the prelimbic cortex of WT vs SERT Met172 mice after acute cocaine treatment_FDR_subset0.05
			LABEL: Differential gene expression in the prelimbic cortex of WT vs SERT Met172 mice after acute cocaine treatment_FDR_subset0.05 DESCRIPTION: To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Tier IV	Mouse	13178 Genes	GS408394 Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after chronic cocaine treatment_logFC
			LABEL: Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after chronic cocaine treatment_logFC DESCRIPTION: To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Tier IV	Mouse	13178 Genes	GS408395 Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after chronic cocaine treatment_FDR
			LABEL: Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after chronic cocaine treatment_FDR DESCRIPTION: To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Tier IV	Mouse	293 Genes	GS408397 Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after chronic cocaine treatment_FDR_subset0.05
			LABEL: Differential gene expression in the nucleus accumbens of WT vs SERT Met172 mice after chronic cocaine treatment_FDR_subset0.05 DESCRIPTION: To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Tier IV	Mouse	13178 Genes	GS408398 Differential gene expression in the prelimbic cortex of WT and SERT Met172 mice after chronic cocaine treatment_logFC
			LABEL: Differential gene expression in the prelimbic cortex of WT and SERT Met172 mice after chronic cocaine treatment_logFC DESCRIPTION: To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Tier IV	Mouse	13178 Genes	GS408400 Differential gene expression in the prelimbic cortex of WT and SERT Met172 mice after chronic cocaine treatment_FDR
			LABEL: Differential gene expression in the prelimbic cortex of WT and SERT Met172 mice after chronic cocaine treatment_FDR DESCRIPTION: To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.
Tier IV	Mouse	1 Genes	GS408401 Differential gene expression in the prelimbic cortex of WT and SERT Met172 mice after chronic cocaine treatment_FDR_subset0.05
			LABEL: Differential gene expression in the prelimbic cortex of WT and SERT Met172 mice after chronic cocaine treatment_FDR_subset0.05 DESCRIPTION: To elucidate 5-HT transporter (SERT)-specific contributions to cocaine action, we evaluated cocaine effects in the SERT Met172 knock-in mouse, which expresses a SERT coding substitution that eliminates high-affinity cocaine recognition. We measured the effects of SERT Met172 on cocaine antagonism of 5-HT re-uptake using ex vivo synaptosome preparations and in vivo microdialysis. We assessed SERT dependence of cocaine actions behaviourally through acute and chronic locomotor activation, sensitization, conditioned place preference (CPP) and oral cocaine consumption.

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351

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