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GeneSets Sharing a Publication with GS408305

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					GeneSet Title
	Tier III	Rat		32884 Genes	GS407906 Differential gene expression in ventral tegmental area of rats with heroin self-administration_Log2FC
					LABEL: Heroin_rat_VTA_Log2FC DESCRIPTION: H3 dopaminylation at glutamine 5 (H3Q5dop) plays a critical role in heroin-mediated transcriptional plasticity in midbrain regions, particularly the VTA. In rats undergoing abstinence from heroin self-administration (SA), we found acute and persistent accumulation of H3Q5dop in VTA. Attenuation of H3Q5dop during abstinence induced persistent changes in gene expression programs associated with neuronal signaling and dopaminergic function in heroin abstinence and led to reduced heroin-seeking behavior. Interestingly, the observed changes in molecular pathways after heroin SA showed significant yet reversed overlap with the same genes altered in cocaine SA.
	Tier III	Rat		32884 Genes	GS407907 Differential gene expression in ventral tegmental area of rats with heroin self-administration_FDR
					LABEL: Heroin_rat_VTA_FDR DESCRIPTION: H3 dopaminylation at glutamine 5 (H3Q5dop) plays a critical role in heroin-mediated transcriptional plasticity in midbrain regions, particularly the VTA. In rats undergoing abstinence from heroin self-administration (SA), we found acute and persistent accumulation of H3Q5dop in VTA. Attenuation of H3Q5dop during abstinence induced persistent changes in gene expression programs associated with neuronal signaling and dopaminergic function in heroin abstinence and led to reduced heroin-seeking behavior. Interestingly, the observed changes in molecular pathways after heroin SA showed significant yet reversed overlap with the same genes altered in cocaine SA.
	Tier IV	Rat		570 Genes	GS408305 Differential gene expression in ventral tegmental area of rats with heroin self-administration_FDR_subset0.05
					LABEL: Heroin_rat_ventral tegmental area_FDR_subset0.05 DESCRIPTION: Subset of GS407907 for only differentially expressed genes at FDR < 0.05.
	Tier IV	Rat		570 Genes	GS408306 Differential gene expression in ventral tegmental area of rats with heroin self-administration_FDR_subset0.05
					LABEL: Heroin_rat_ventral tegmental area_FDR_subset0.05 DESCRIPTION: Subset of GS407907 for only differentially expressed genes at FDR < 0.05.

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351