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			GeneSet Title
Tier IV	Rat	5 Genes	GS400107 Rat WIN 55,212-2 (WIN) vs control (RNA-seq)
			LABEL: rat WIN vs cont DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not. Gene expression was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S2. Values presented are p-adjusted values.
Tier IV	Rat	17 Genes	GS400108 Rat WIN 55,212-2 (WIN)-Cocaine vs Cocaine (RNA-seq)
			LABEL: WIN-Coca. Vs Cocaine DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not. Gene expression was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S2. Values presented are p-adjusted values.
Tier IV	Rat	5 Genes	GS400109 Rat WIN 55,212-2 (WIN)-Cocaine vs. Control (RNA-seq)
			LABEL: rat WIN-Coca. Vs Control DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not. Gene expression was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S2. Values presented are p-adjusted values.
Tier IV	Rat	56086 Genes	GS400111 Rat Cocaine vs Control (RNA-seq)
			LABEL: rat cocaine vs cont DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not. Gene expression was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S2. Values presented are p-adjusted values.
Tier IV	Rat	35023 Genes	GS400115 WIN 55,212-2 (WIN) vs control skipped exon - rat (RNA-seq)
			LABEL: rat WIN vs cont SE DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not. Skipped exon (SE) events were evaluated. Gene expression was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S3. Values presented are p-values.
Tier IV	Rat	11534 Genes	GS400116 Rat WIN 55,212-2-Cocaine vs. Cocaine skipped exon (RNA-seq)
			LABEL: rat WIN-Coca. vs Cocaine SE DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not. Skipped exon (SE) events were evaluated. Gene expression was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S3. Values presented are p-values.
Tier IV	Rat	5974 Genes	GS400117 RAT WIN 55,212-2-Cocaine vs. Control skipped exon (RNA-seq)
			LABEL: rat WIN-Coca. vs Control SE DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not. Skipped exon (SE) events were evaluated. Gene expression was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S3. Values presented are p-values.
Tier IV	Rat	32438 Genes	GS400118 Rat Cocaine vs. Control skipped exon (RNA-seq)
			LABEL: rat Cocaine vs Control SE DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not. Skipped exon (SE) events were evaluated. Gene expression was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S3. Values presented are p-values.
Tier IV	Rat	968 Genes	GS400119 Differentially expressed rat nuclear proteins (cocaine) (RNA-seq)
			LABEL: rat cocaine nuc diff prot expn DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not (+/- WIN and +/- cocaine). Differential protein expression in the nucleus was evaluated across all four adolescent treatment groups. Gene expression was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S4. Values presented are p-adjusted values.
Tier IV	Rat	94 Genes	GS400120 Differentially expressed rat cytoplasmic proteins (cocaine) (RNA-seq)
			LABEL: rat cocaine cytoplasm diff prot expn DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not (+/- WIN and +/- cocaine). Differential protein expression in the cytoplasm was evaluated across all four adolescent treatment groups. Gene expression was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S5. Values presented are p-adjusted values.
Tier IV	Rat	22 Genes	GS400121 Rat Phospho-proteomics (cocaine)
			LABEL: rat cocaine phospho-proteomics DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not (+/- WIN and +/- cocaine). Differential protein phosphorylation was evaluated across all four adolescent treatment groups. Gene expression was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S6. Values presented are p-adjusted values.
Tier IV	Rat	2041 Genes	GS400122 Differential expression analysis of rat synaptosomal extracts (cocaine) (RNA-seq)
			LABEL: rat cocaine synaptosome DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not (+/- WIN and +/- cocaine). Differential synaptosome protein expression was evaluated across all four adolescent treatment groups. Gene expression was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S7. Values presented are p-adjusted values.
Tier IV	Rat	22 Genes	GS400123 Differentially expressed genes in the rat nucleus accumbens (WIN 55,212-2 (WIN)-cocaine) - RNA-seq
			LABEL: rat cocaine NAcc DEG DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not (+/- WIN and +/- cocaine). Differential gene expression in the nucleus accumbens was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S8. Values presented are p-adjusted values.
Tier IV	Rat	270 Genes	GS400124 Differential expression analysis of rat cytoplasmic extracts (cocaine) (RNA-seq)
			LABEL: rat cocaine Cytosol diff expn DESCRIPTION: Adolescent male Sprague-Dawley rats were either exposed to the synthetic cannabinoid WIN 55,212-2 (WIN) prior to cocaine administration or not (+/- WIN and +/- cocaine). Differential cytosolic protein expression was evaluated across all four adolescent treatment groups. Gene expression was evaluated via RNA-seq. Data available at GEO with accession number GSE134935. Data taken from Supplementary Dataset S7. Values presented are p-adjusted values.

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351

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