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					GeneSet Title
	Tier IV	Mouse		23 Genes	GS400087 24-h genes: List of mouse genes that show overlap of cocaine-induced changes by 5hmC-seq and RNA-seq
					LABEL: mouse 5hmC cocaine 24h DESCRIPTION: 24 genes that are differentially expressed and have differential 5-hydroxymethylcytosine (5hmC) levels within 24 h in response to cocaine in adult (8-10 week) male C57BL/6J mice. Gene expression and 5hmC levels were measured via RNA-seq and 5hmC-seq, respectively. Data taken from Table 1. Values presented are "1" for presence. Data available at GEO with accession number GSE63749.
	Tier V	Mouse		0 Genes	GS400091 Gene regions that display cocaine-induced changes in 5hmC
					LABEL: mouse 5hmC cocaine DESCRIPTION: Genes that have regions with differential 5-hydroxymethylcytosine (5hmC) levels in response to cocaine in adult (8-10 week) male C57BL/6J mice. 5hmC levels were measured via 5hmC-seq. Data taken from Supplementary Table 2. Values presented are p-values. Data available at GEO with accession number GSE63749.
	Tier III	Mouse		3730 Genes	GS400093 Mouse gene regions that display cocaine-induced changes in 5hmC (5hmC-seq)
					LABEL: mouse 5hmC cocaine DESCRIPTION: Genes that have regions with differential 5-hydroxymethylcytosine (5hmC) levels in response to cocaine in adult (8-10 week) male C57BL/6J mice. 5hmC levels were measured via 5hmC-seq. Data taken from Supplementary Table 2. Values presented are p-values. Data available at GEO with accession number GSE63749.
	Tier IV	Mouse		1576 Genes	GS400095 Mouse genes whose putative nearby enhancers show cocaine-induced switches to chromatin state 4 or 5
					LABEL: mouse cocaine enhancers DESCRIPTION: Genes that have enhancers which have changes in chromatin structure to state 4 or 5 in response to cocaine in adult (8-10 week) male C57BL/6J mice. 5hmC levels were measured via 5hmC-seq. Data taken from Supplementary Table 3. Values presented are "1" for presence. Data available at GEO with accession number GSE63749.
	Tier IV	Mouse		16 Genes	GS400096 Mouse genes that show overlap in cocaine regulation of 5hmC and alternative splicing
					LABEL: mouse cocaine alt splice DESCRIPTION: Genes that have both differential 5-hydroxymethylcytosine (5hmC) levels and alternative splicing patterns in response to cocaine in adult (8-10 week) male C57BL/6J mice. 5hmC levels were measured via 5hmC-seq. Data taken from Supplementary Table 6. Values presented are log2 fold change for 5hmC levels. Data available at GEO with accession number GSE63749.

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351