GeneSet Title
Tier V
Mouse
438 Genes
GS354301
LABEL: Upregulated in Eif2ak4-/- all AAsDESCRIPTION: Genes upregulated in livers of Eif2ak4(Gcn2)-mutant mice 30 minutes after perfusion with all amino acids. This is the control experiment to test response to amino-acid starvation. Sequences reported in the manuscript were used to search the MGI resource using the batch query form on June 15, 2018. Sequences that did not match were investigated manually. Sequences that were associated with putative assignments to gene identifiers were included. Values represent z-scores. Higher scores were used for genes represented more than once.
Tier V
Mouse
505 Genes
GS354303
LABEL: Upregulated in Eif2ak4-/- w/o MetDESCRIPTION: Genes upregulated in livers of Eif2ak4(Gcn2)-mutant mice 30 minutes after perfusion with amino acids lacking methionine. Sequences reported in the manuscript were used to search the MGI resource using the batch query form on June 15, 2018. Sequences that did not match were investigated manually. Sequences that were associated with putative assignments to gene identifiers were included. Values represent z-scores. Higher scores were used for genes represented more than once.
Tier V
Mouse
492 Genes
GS354304
LABEL: Downregulated in Eif2ak4-/- all AADESCRIPTION: Genes downregulated in livers of Eif2ak4(Gcn2)-mutant mice 30 minutes after perfusion with all amino acids. Sequences reported in the manuscript were used to search the MGI resource using the batch query form on June 15, 2018. Sequences that did not match were investigated manually. Sequences that were associated with putative assignments to gene identifiers were included. Values represent z-scores. Higher scores were used for genes represented more than once.
Tier III
Mouse
522 Genes
GS354317
LABEL: Downregulated in Eif2ak4-/- no MetDESCRIPTION: Genes downregulated in livers of Eif2ak4(Gcn2)-mutant mice 30 minutes after perfusion with amino acids lacking methionine. Removing methionine induces amino-acid starvation. Sequences reported in the manuscript were used to search the MGI resource using the batch query form on June 15, 2018. Sequences that did not match were investigated manually. Sequences that were associated with putative assignments to gene identifiers were included. Values represent z-scores. Higher scores were used for genes represented more than once.
Tier V
Mouse
560 Genes
GS354321
LABEL: Up in Eif2ak3 -/-DESCRIPTION: Genes upregulated in livers of Eif2ak3(Perk)-mutant mice 30 minutes after perfusion without tBuHQ. tBuHQ is used to generate ER-stress. Sequences reported in the manuscript were used to search the Mouse Genome Informatics (MGI) resource using the batch query form on June 22, 2018. Sequences that did not match were investigated manually. In some cases, sequence identifiers were identified by cross-referencing the array data in the Gene Expression Omnibus. Sequences that were associated with putative assignments to gene identifiers via a 'probe' relationship in MGI were included. Values represent z-scores. Higher scores were used for genes represented more than once.
Tier V
Mouse
711 Genes
GS354360
LABEL: Up in Eif2ak3 with tBuHQDESCRIPTION: Genes upregulated in livers of Eif2ak3(Perk)-mutant mice 30 minutes after perfusion witht tBuHQ. tBuHQ is used to generate ER-stress. Sequences reported in the manuscript were used to search the Mouse Genome Informatics (MGI) resource using the batch query form on June 22, 2018. Sequences that did not match were investigated manually. In some cases, sequence identifiers were identified by cross-referencing the array data in the Gene Expression Omnibus. Sequences that were associated with putative assignments to gene identifiers via a 'probe' relationship in MGI were included. Values represent z-scores. Higher scores were used for genes represented more than once.
Tier V
Mouse
868 Genes
GS354488
LABEL: Downregulated in Eif2ak3-/-DESCRIPTION: Genes downregulated in livers of Eif2ak3(Perk)-mutant mice 30 minutes after perfusion without tBuHQ. tBuHQ is used to generate ER-stress. Sequences reported in the manuscript were used to search the Mouse Genome Informatics (MGI) resource using the batch query form on June 22, 2018. Sequences that did not match were investigated manually. In some cases, sequence identifiers were identified by cross-referencing the array data in the Gene Expression Omnibus. Sequences that were associated with putative assignments to gene identifiers via a 'probe' relationship in MGI were included. Values represent z-scores. Higher scores were used for genes represented more than once.
Tier III
Mouse
636 Genes
GS354521
LABEL: Down in Eif2ak3 with tBuHQDESCRIPTION: Genes downregulated in livers of Eif2ak3(Perk)-mutant mice 30 minutes after perfusion witht tBuHQ. tBuHQ is used to generate ER-stress. Sequences reported in the manuscript were used to search the Mouse Genome Informatics (MGI) resource using the batch query form on June 22, 2018. Sequences that did not match were investigated manually. In some cases, sequence identifiers were identified by cross-referencing the array data in the Gene Expression Omnibus. Sequences that were associated with putative assignments to gene identifiers via a 'probe' relationship in MGI were included. Values represent z-scores. Higher scores were used for genes represented more than once.
Tier V
Mouse
480 Genes
GS354671
LABEL: Genes moving into polysomes after Methionine starvationDESCRIPTION: The effect of GCN2 activation on individual mRNAs into polysomes, as an indicator of translation, was assessed by Methionine deprivation.
This was followed by sucrose density gradient centrifugation to separate mRNAs present in polysomes from those not present (i.e., those being translated from those that are untranslated).
Tier V
Mouse
437 Genes
GS354672
LABEL: Genes moving out of polysomes following Methionine deprivationDESCRIPTION: The effect of GCN2 activation on individual mRNAs shifting out of polysomes, was assessed by Methionine deprivation. This was followed by sucrose density gradient centrifugation to separate mRNAs shifting out of polysomes in mouse liver.
Tier V
Mouse
551 Genes
GS355697
LABEL: Downregulated in Eif2ak4-/- no MetDESCRIPTION: Genes downregulated in livers of Eif2ak4(Gcn2)-mutant mice 30 minutes after perfusion with amino acids lacking methionine. Removing methionine induces amino-acid starvation. Probe identifiers reported in the manuscript were entered. Values represent z-scores.
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