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LABEL: Scopolamine rats diff. genes DESCRIPTION: Scopolamine hydrobromide (Sigma, St Louis, MO, USA) was dissolved in physiological saline and administered (0.4 mg/kg i.p.) to 58 7-month-old male Long-Evans rats 20 min before MWM training daily for 4 days. Control animals were administered an equal volume of physiological saline. Gene expression profiles of the dorsal hippocampus of each animal were investigated using individual Affymetrix high-density oligonucleotide microarrays containing 28,757 different genes. Fold change was uploaded.
LABEL: Rat drug induced amnesia Genes DESCRIPTION: Genes differentially expressed between scopolamine- and saline-treated rats following stimulation in a spatial memory task. Genes down-regulated in scopolamine-treated rats compared to saline-treated animals are indicated by a negative sign whereas genes up-regulated are represented by positive values. Fold changes and bounds of the 95% CI are derived from the average measures obtained with the log2 scale robust multi-array Averaging methods to analyse microarray data.Fold change was uploaded.