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					GeneSet Title
	Tier III	Human		5 Genes	GS135216 Gene Coexpression Networks in Human Brain Identify Epigenetic Modifications in Alcohol Dependence
					LABEL: Coexpression-Alcohol Dependance DESCRIPTION: We applied a novel systems approach to transcriptome profiling in postmortem human brains and generated a systemic view of brain alterations associated with alcohol abuse. We identified critical cellular components and previously unrecognized epigenetic determinants of gene coexpression relationships and discovered novel markers of chromatin modifications in alcoholic brain. Higher expression levels of endogenous retroviruses and genes with high GC content in alcoholics were associated with DNA hypomethylation and increased histone H3K4 trimethylation, suggesting a critical role of epigenetic mechanisms in alcohol addiction. Analysis of cell-type-specific transcriptomes revealed remarkable consistency between molecular profiles and cellular abnormalities in alcoholic brain.Statistics reported as P-values.
	Tier III	Human		3026 Genes	GS137407 Overall results of WGCNA combined with differential expression in BLA between AUD vs controls
					LABEL: BLA AUD vs control DESCRIPTION: Supplementary Table 2. Overall results of WGCNA combined with differential expression between people with a history of alcohol use and controls BLA: basolateral amygdala
	Tier III	Human		2272 Genes	GS137413 Overall results of WGCNA combined with differential expression in CNA between people with a history of alcohol use and controls
					LABEL: CNA alcoholic vs control DESCRIPTION: Supplementary Table 2. Overall results of WGCNA combined with differential expression between alcoholics and controls CNA: central nucleus of amygdala
	Tier V	Human		6 Genes	GS405325 Genes dervied from the GeneSet: Gene Coexpression Networks in Human Brain Identify Epigenetic Modifications in Alcohol Dependence
					LABEL: AP Research - test trial DESCRIPTION: Genes dervied from the GeneSet: Gene Coexpression Networks in Human Brain Identify Epigenetic Modifications in Alcohol Dependence

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Supported by NIH R01 AA18776 jointly funded by NIAAA and NIDA, and JAX Center for Precision Genetics NIH U54 OD 020351